C3LRM2 (CYSD_VIBCM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sulfate adenylyltransferase subunit 2
EC=2.7.7.4

Alternative name(s):
ATP-sulfurylase small subunit
Sulfate adenylate transferase
Short name=SAT

Gene names

Name:	cysD
Ordered Locus Names:	VCM66_2480

Organism

Vibrio cholerae serotype O1 (strain M66-2) [Complete proteome] [HAMAP]

Taxonomic identifier

579112 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	302 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + sulfate = diphosphate + adenylyl sulfate. HAMAP MF_00064
Pathway	Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3. HAMAP MF_00064
Subunit structure	Heterodimer composed of CysD, the smaller subunit, and CysN By similarity.
Sequence similarities	Belongs to the PAPS reductase family. CysD subfamily.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	sulfate reduction Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW sulfate adenylyltransferase (ATP) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 302	302	Sulfate adenylyltransferase subunit 2 HAMAP MF_00064		PRO_1000117948

Sequences

	Sequence		Length	Mass (Da)
	C3LRM2 [UniParc]. Last modified June 16, 2009. Version 1. Checksum: CF2212D3C20FA20D	FASTA	302	35,073
	10 20 30 40 50 60 MDQQRLTHLK QLEAESIHII REVAAEFDNP VMMYSIGKDS SVMLHLTRKA FYPGKIPFPL 70 80 90 100 110 120 LHVDTDWKFR DMITFRDTTA KKYGFDLIVH KNPEGLAAGI NPFDHGSSKH TDIMKTQGLK 130 140 150 160 170 180 QALNKYGFDA AFGGARRDEE KSRAKERVYS FRDKNHTWDP KNQRPELWRT YNGQINKGES 190 200 210 220 230 240 IRVFPLSNWT ELDIWQYIYL ENIEIVPLYL ADVRPVVQRD GMLIMVDDDR MKLREGEQIE 250 260 270 280 290 300 HKSVRFRTLG CYPLTGAIES QANTLTEIIE EMLVATSSER QGRAIDHDQS GSMELKKRQG YF

References

[1]

"A recalibrated molecular clock and independent origins for the cholera pandemic clones." Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L. PLoS ONE 3:E4053-E4053(2008) [PubMed: 19115014] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: M66-2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001233 Genomic DNA. Translation: ACP06777.1.
RefSeq	YP_002811228.1. NC_012578.1.
3D structure databases
ProteinModelPortal	C3LRM2.
SMR	C3LRM2. Positions 5-211.
ModBase	Search...
Protein-protein interaction databases
STRING	C3LRM2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7773738.
GenomeReviews	Gene locus VCM66_2480 in contig CP001233_GR.
KEGG	vcm:VCM66_2480.
PATRIC	20068682. VBIVibCho108967_2359.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	RVIDHDA.
ProtClustDB	PRK05253.
Family and domain databases
HAMAP	MF_00064. Sulf_adenylyltr_sub2. [Tree]
InterPro	IPR002500. PAPS_reduct. IPR014729. Rossmann-like_a/b/a_fold. IPR011784. SO4_adenylTrfase_ssu. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 2 hits.
KO	K00957.
Pfam	PF01507. PAPS_reduct. 1 hit. [Graphical view]
PIRSF	PIRSF002936. CysDAde_trans. 1 hit.
TIGRFAMs	TIGR02039. CysD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CYSD_VIBCM

Accession

Primary (citable) accession number: C3LRM2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	June 16, 2009
Last modified:	January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program