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C3LRA4 (C3LRA4_VIBCM) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Alanine racemase HAMAP-Rule MF_01201

EC=5.1.1.1 HAMAP-Rule MF_01201
Gene names
Name:alr EMBL ACP04684.1
Ordered Locus Names:VCM66_0356 EMBL ACP04684.1
OrganismVibrio cholerae serotype O1 (strain M66-2) [Complete proteome] [HAMAP] EMBL ACP04684.1
Taxonomic identifier579112 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201 SAAS SAAS009006

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201 SAAS SAAS009006

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family. HAMAP-Rule MF_01201 RuleBase RU004188

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site481Proton acceptor; specific for D-alanine By similarity HAMAP-Rule MF_01201
Active site2681Proton acceptor; specific for L-alanine By similarity HAMAP-Rule MF_01201
Binding site1431Substrate By similarity HAMAP-Rule MF_01201
Binding site3161Substrate; via amide nitrogen By similarity HAMAP-Rule MF_01201

Amino acid modifications

Modified residue481N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01201

Sequences

Sequence LengthMass (Da)Tools
C3LRA4 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: DD997445886FBC07

FASTA37541,001
        10         20         30         40         50         60 
MLDLHLTMSN SMNYMKAATA YINLEALQHN LQRVKQQAPE SKIMAVVKAN GYGHGLRHIA 

        70         80         90        100        110        120 
RHALGADAFG VARIEEALQL RASGVVKPIL LLEGFYSPGD LPVLVTNNIQ TVVHCEEQLQ 

       130        140        150        160        170        180 
ALEQAQLETP VMVWLKVDSG MHRLGVRPEQ YQDFVARLHQ CENVAKPLRY MSHFGCADEL 

       190        200        210        220        230        240 
DKSTTVEQTE LFLSLTQGCQ GERSLAASAG LLAWPQSQLE WVRPGIIMYG VSPFVEKSAV 

       250        260        270        280        290        300 
QLGYQPVMTL KSHLIAVREV KAGESVGYGG TWTSQRDTKI GVIAIGYGDG YPRTAPNGTP 

       310        320        330        340        350        360 
VVVNGRRVPI AGRVSMDMLT VDLGPDACDR VGDEAMLWGN ELPVEEVAAH IGTIGYELVT 

       370 
KLTSRVEMSY YGAGV 

« Hide

References

[1]"A recalibrated molecular clock and independent origins for the cholera pandemic clones."
Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: M66-2 EMBL ACP04684.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001233 Genomic DNA. Translation: ACP04684.1.
RefSeqYP_002809135.1. NC_012578.1.

3D structure databases

ProteinModelPortalC3LRA4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING579112.VCM66_0356.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACP04684; ACP04684; VCM66_0356.
GeneID7771645.
KEGGvcm:VCM66_0356.
PATRIC20064496. VBIVibCho108967_0339.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0787.
HOGENOMHOG000031446.
KOK01775.
OMAINNQLAP.
OrthoDBEOG6PP9NJ.
ProtClustDBPRK00053.

Enzyme and pathway databases

BioCycVCHO579112:GJAW-388-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC3LRA4_VIBCM
AccessionPrimary (citable) accession number: C3LRA4
Entry history
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: February 19, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)