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C3LQR0

- GPPA_VIBCM

UniProt

C3LQR0 - GPPA_VIBCM

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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene
gppA, VCM66_0289
Organism
Vibrio cholerae serotype O1 (strain M66-2)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. guanosine pentaphosphate catabolic process Source: InterPro
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciVCHO579112:GJAW-304-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (EC:3.6.1.40)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene namesi
Name:gppA
Ordered Locus Names:VCM66_0289
OrganismiVibrio cholerae serotype O1 (strain M66-2)
Taxonomic identifieri579112 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000001217: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotationPRO_1000185316Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi579112.VCM66_0289.

Structurei

3D structure databases

ProteinModelPortaliC3LQR0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiGLHIEYK.
OrthoDBiEOG6M6JN6.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3LQR0-1 [UniParc]FASTAAdd to Basket

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MSQAVSSPLY AAIDLGSNSF HMLVVRHIDG SVQTMAKIKR KVRLAAGLDE    50
HNALSLDAMQ RGWDCLSLFA ERLQDIPAEN IRIVGTATLR TATNAGEFIA 100
KANQILGHPI DVISGEEEAA TIYKGVAHTS GGLGRRLVVD IGGASTELII 150
GEGFEAKALT SLKMGCVTWL ERHFKDRQLT ATNFNNAILA AKQMLDPILT 200
QYTELGWNVC VGASGTVQAL QEIMLAQGMD EVITLTKLKR LQKQAMLADH 250
LEELDIEGLT LERALVFPSG LSILIAIFES LNIEAMTLAG GALREGLVYE 300
MVQDLRQEDI RARTIRCVQT RYQIDSAYGD QVATLASKLL AQCGGEAWIN 350
EPQAEMLLRT AAKLHEIGLT IDFKKGGEHS AYLLQHLDLP GYTRAQKHYL 400
GEIVRRYREQ LTSLPEQYAL SGTSGKRVLR LLRLAVLLSH RRSPALEPMV 450
ELSAQEDKLT LTLDGEWLAK NPLTRTELEL EANRQTDIGW PLSIECH 497
Length:497
Mass (Da):54,826
Last modified:June 16, 2009 - v1
Checksum:iBB0BD17FF3B3A331
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001233 Genomic DNA. Translation: ACP04618.1.
RefSeqiYP_002809069.1. NC_012578.1.

Genome annotation databases

EnsemblBacteriaiACP04618; ACP04618; VCM66_0289.
GeneIDi7771579.
KEGGivcm:VCM66_0289.
PATRICi20064334. VBIVibCho108967_0276.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001233 Genomic DNA. Translation: ACP04618.1 .
RefSeqi YP_002809069.1. NC_012578.1.

3D structure databases

ProteinModelPortali C3LQR0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 579112.VCM66_0289.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACP04618 ; ACP04618 ; VCM66_0289 .
GeneIDi 7771579.
KEGGi vcm:VCM66_0289.
PATRICi 20064334. VBIVibCho108967_0276.

Phylogenomic databases

eggNOGi COG0248.
HOGENOMi HOG000258672.
KOi K01524.
OMAi GLHIEYK.
OrthoDBi EOG6M6JN6.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .
BioCyci VCHO579112:GJAW-304-MONOMER.

Family and domain databases

HAMAPi MF_01550. GppA.
InterProi IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
    Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
    PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M66-2.

Entry informationi

Entry nameiGPPA_VIBCM
AccessioniPrimary (citable) accession number: C3LQR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: May 14, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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