Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

C3LPN0

- PUR5_VIBCM

UniProt

C3LPN0 - PUR5_VIBCM

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Vibrio cholerae serotype O1 (strain M66-2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciVCHO579112:GJAW-2230-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:VCM66_2149
    OrganismiVibrio cholerae serotype O1 (strain M66-2)
    Taxonomic identifieri579112 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000001217: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000148307Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi579112.VCM66_2149.

    Structurei

    3D structure databases

    ProteinModelPortaliC3LPN0.
    SMRiC3LPN0. Positions 7-343.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229091.
    KOiK01933.
    OMAiEFEMYRT.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C3LPN0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGNNPSLSY KDAGVDIDAG NALVERIKGA VKRTRRPEVM GGLGGFGALC    50
    ELPTKYKHPV LVSGTDGVGT KLRLALDMKK HDTIGIDLVA MCVNDLIVQG 100
    AEPLFFLDYY ATGKLDVDTA AEVISGIADG CLQAGCALIG GETAEMPGMY 150
    EGEDYDVAGF CVGVVEKEEI IDGSKVQVGD ALIAVGSSGP HSNGYSLVRK 200
    ILEVSKADKN ERLAGKTIGE HLLAPTKIYI KSGLKLIAEH DIHAISHITG 250
    GGFWENIPRV LPEGTKAVID GKSWEWPVIF QWLQEKGNVT THEMYRTFNC 300
    GVGLIIALPK DQANAAVALL QAEGETAWVI GEIAAANSNE AQVEIN 346
    Length:346
    Mass (Da):36,773
    Last modified:June 16, 2009 - v1
    Checksum:iD440BA2570E5DC0D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001233 Genomic DNA. Translation: ACP06450.1.
    RefSeqiYP_002810901.1. NC_012578.1.

    Genome annotation databases

    EnsemblBacteriaiACP06450; ACP06450; VCM66_2149.
    GeneIDi7773411.
    KEGGivcm:VCM66_2149.
    PATRICi20068041. VBIVibCho108967_2047.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001233 Genomic DNA. Translation: ACP06450.1 .
    RefSeqi YP_002810901.1. NC_012578.1.

    3D structure databases

    ProteinModelPortali C3LPN0.
    SMRi C3LPN0. Positions 7-343.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 579112.VCM66_2149.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACP06450 ; ACP06450 ; VCM66_2149 .
    GeneIDi 7773411.
    KEGGi vcm:VCM66_2149.
    PATRICi 20068041. VBIVibCho108967_2047.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229091.
    KOi K01933.
    OMAi EFEMYRT.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci VCHO579112:GJAW-2230-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
      Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
      PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: M66-2.

    Entry informationi

    Entry nameiPUR5_VIBCM
    AccessioniPrimary (citable) accession number: C3LPN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3