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C3LPI0 (KDSA_VIBCM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-dehydro-3-deoxyphosphooctonate aldolase

EC=2.5.1.55
Alternative name(s):
3-deoxy-D-manno-octulosonic acid 8-phosphate synthase
KDO-8-phosphate synthase
Short name=KDO 8-P synthase
Short name=KDOPS
Phospho-2-dehydro-3-deoxyoctonate aldolase
Gene names
Name:kdsA
Ordered Locus Names:VCM66_2098
OrganismVibrio cholerae serotype O1 (strain M66-2) [Complete proteome] [HAMAP]
Taxonomic identifier579112 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate. HAMAP-Rule MF_00056

Pathway

Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3. HAMAP-Rule MF_00056

Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP-Rule MF_00056

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00056.

Sequence similarities

Belongs to the KdsA family.

Ontologies

Keywords
   Biological processLipopolysaccharide biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processketo-3-deoxy-D-manno-octulosonic acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function3-deoxy-8-phosphooctulonate synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2832832-dehydro-3-deoxyphosphooctonate aldolase HAMAP-Rule MF_00056
PRO_1000117792

Sequences

Sequence LengthMass (Da)Tools
C3LPI0 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: D174E0105F98C09D

FASTA28330,773
        10         20         30         40         50         60 
MEHKIVHVGD IPVANDKPFT LFAGMNVLES RDLAMQICEH YVKVTDKLGI PYVFKASFDK 

        70         80         90        100        110        120 
ANRSSVHSYR GPGLEEGMKI FQELKETFGV KIITDVHTEA QAQPVADVVD VIQLPAFLAR 

       130        140        150        160        170        180 
QTDLVEAMAK TGAVINVKKP QFMSPGQVGN IVEKFAECGN DKVILCERGS CHGYDNLVVD 

       190        200        210        220        230        240 
MLGFGVMKQA SNGSPIIFDV THSLQMRDPS GAASGGRREQ TVELAKAGLA TGIAGLFIEA 

       250        260        270        280 
HPNPDKARCD GPSALPLDKL EPFLAQMKAL DDLIKSFAHI DIR 

« Hide

References

[1]"A recalibrated molecular clock and independent origins for the cholera pandemic clones."
Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: M66-2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001233 Genomic DNA. Translation: ACP06400.1.
RefSeqYP_002810851.1. NC_012578.1.

3D structure databases

ProteinModelPortalC3LPI0.
SMRC3LPI0. Positions 1-281.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING579112.VCM66_2098.

Proteomic databases

PRIDEC3LPI0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACP06400; ACP06400; VCM66_2098.
GeneID7773361.
KEGGvcm:VCM66_2098.
PATRIC20067907. VBIVibCho108967_1997.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2877.
HOGENOMHOG000023021.
KOK01627.
OMAANDKPMV.
OrthoDBEOG680X4R.

Enzyme and pathway databases

BioCycVCHO579112:GJAW-2163-MONOMER.
UniPathwayUPA00030.
UPA00357; UER00474.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00056. KDO8P_synth.
InterProIPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006269. KDO8P_synthase.
[Graphical view]
PANTHERPTHR21057:SF2. PTHR21057:SF2. 1 hit.
PfamPF00793. DAHP_synth_1. 1 hit.
[Graphical view]
TIGRFAMsTIGR01362. KDO8P_synth. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKDSA_VIBCM
AccessionPrimary (citable) accession number: C3LPI0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: May 14, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways