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C3LPI0

- KDSA_VIBCM

UniProt

C3LPI0 - KDSA_VIBCM

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Protein
2-dehydro-3-deoxyphosphooctonate aldolase
Gene
kdsA, VCM66_2098
Organism
Vibrio cholerae serotype O1 (strain M66-2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 3-deoxy-8-phosphooctulonate synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciVCHO579112:GJAW-2163-MONOMER.
UniPathwayiUPA00030.
UPA00357; UER00474.

Names & Taxonomyi

Protein namesi
Recommended name:
2-dehydro-3-deoxyphosphooctonate aldolase (EC:2.5.1.55)
Alternative name(s):
3-deoxy-D-manno-octulosonic acid 8-phosphate synthase
KDO-8-phosphate synthase
Short name:
KDO 8-P synthase
Short name:
KDOPS
Phospho-2-dehydro-3-deoxyoctonate aldolase
Gene namesi
Name:kdsA
Ordered Locus Names:VCM66_2098
OrganismiVibrio cholerae serotype O1 (strain M66-2)
Taxonomic identifieri579112 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000001217: Chromosome I

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2832832-dehydro-3-deoxyphosphooctonate aldolaseUniRule annotation
PRO_1000117792Add
BLAST

Proteomic databases

PRIDEiC3LPI0.

Interactioni

Protein-protein interaction databases

STRINGi579112.VCM66_2098.

Structurei

3D structure databases

ProteinModelPortaliC3LPI0.
SMRiC3LPI0. Positions 1-281.

Family & Domainsi

Sequence similaritiesi

Belongs to the KdsA family.

Phylogenomic databases

eggNOGiCOG2877.
HOGENOMiHOG000023021.
KOiK01627.
OMAiANDKPMV.
OrthoDBiEOG680X4R.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00056. KDO8P_synth.
InterProiIPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006269. KDO8P_synthase.
[Graphical view]
PANTHERiPTHR21057:SF2. PTHR21057:SF2. 1 hit.
PfamiPF00793. DAHP_synth_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01362. KDO8P_synth. 1 hit.

Sequencei

Sequence statusi: Complete.

C3LPI0-1 [UniParc]FASTAAdd to Basket

« Hide

MEHKIVHVGD IPVANDKPFT LFAGMNVLES RDLAMQICEH YVKVTDKLGI    50
PYVFKASFDK ANRSSVHSYR GPGLEEGMKI FQELKETFGV KIITDVHTEA 100
QAQPVADVVD VIQLPAFLAR QTDLVEAMAK TGAVINVKKP QFMSPGQVGN 150
IVEKFAECGN DKVILCERGS CHGYDNLVVD MLGFGVMKQA SNGSPIIFDV 200
THSLQMRDPS GAASGGRREQ TVELAKAGLA TGIAGLFIEA HPNPDKARCD 250
GPSALPLDKL EPFLAQMKAL DDLIKSFAHI DIR 283
Length:283
Mass (Da):30,773
Last modified:June 16, 2009 - v1
Checksum:iD174E0105F98C09D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001233 Genomic DNA. Translation: ACP06400.1.
RefSeqiYP_002810851.1. NC_012578.1.

Genome annotation databases

EnsemblBacteriaiACP06400; ACP06400; VCM66_2098.
GeneIDi7773361.
KEGGivcm:VCM66_2098.
PATRICi20067907. VBIVibCho108967_1997.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001233 Genomic DNA. Translation: ACP06400.1 .
RefSeqi YP_002810851.1. NC_012578.1.

3D structure databases

ProteinModelPortali C3LPI0.
SMRi C3LPI0. Positions 1-281.
ModBasei Search...

Protein-protein interaction databases

STRINGi 579112.VCM66_2098.

Proteomic databases

PRIDEi C3LPI0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACP06400 ; ACP06400 ; VCM66_2098 .
GeneIDi 7773361.
KEGGi vcm:VCM66_2098.
PATRICi 20067907. VBIVibCho108967_1997.

Phylogenomic databases

eggNOGi COG2877.
HOGENOMi HOG000023021.
KOi K01627.
OMAi ANDKPMV.
OrthoDBi EOG680X4R.

Enzyme and pathway databases

UniPathwayi UPA00030 .
UPA00357 ; UER00474 .
BioCyci VCHO579112:GJAW-2163-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00056. KDO8P_synth.
InterProi IPR013785. Aldolase_TIM.
IPR006218. DAHP1/KDSA.
IPR006269. KDO8P_synthase.
[Graphical view ]
PANTHERi PTHR21057:SF2. PTHR21057:SF2. 1 hit.
Pfami PF00793. DAHP_synth_1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01362. KDO8P_synth. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
    Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
    PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M66-2.

Entry informationi

Entry nameiKDSA_VIBCM
AccessioniPrimary (citable) accession number: C3LPI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: May 14, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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