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C3LP79

- RNPA_VIBCM

UniProt

C3LP79 - RNPA_VIBCM

Protein

Ribonuclease P protein component

Gene

rnpA

Organism
Vibrio cholerae serotype O1 (strain M66-2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.UniRule annotation

    Catalytic activityi

    Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.UniRule annotation

    GO - Molecular functioni

    1. ribonuclease P activity Source: UniProtKB-EC
    2. tRNA binding Source: InterPro

    GO - Biological processi

    1. tRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    BioCyciVCHO579112:GJAW-6-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease P protein componentUniRule annotation (EC:3.1.26.5UniRule annotation)
    Short name:
    RNase P proteinUniRule annotation
    Short name:
    RNaseP proteinUniRule annotation
    Alternative name(s):
    Protein C5UniRule annotation
    Gene namesi
    Name:rnpAUniRule annotation
    Ordered Locus Names:VCM66_0006
    OrganismiVibrio cholerae serotype O1 (strain M66-2)
    Taxonomic identifieri579112 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000001217: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 118118Ribonuclease P protein componentPRO_1000194683Add
    BLAST

    Interactioni

    Subunit structurei

    Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.UniRule annotation

    Protein-protein interaction databases

    STRINGi579112.VCM66_0006.

    Structurei

    3D structure databases

    ProteinModelPortaliC3LP79.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RnpA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0594.
    HOGENOMiHOG000266301.
    KOiK03536.
    OMAiPPMDFVV.
    OrthoDBiEOG6C01C6.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    HAMAPiMF_00227. RNase_P.
    InterProiIPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    IPR000100. RNase_P.
    [Graphical view]
    PfamiPF00825. Ribonuclease_P. 1 hit.
    [Graphical view]
    ProDomiPD003629. Ribonuclease_P. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF54211. SSF54211. 1 hit.
    TIGRFAMsiTIGR00188. rnpA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C3LP79-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTYAFNREL RLLTPEHYQK VFQQAHSAGS PHLTIIARAN NLSHPRLGLA    50
    VPKKQIKTAV GRNRFKRICR ESFRLHQNQL ANKDFVVIAK KSAQDLSNEE 100
    LFNLLGKLWQ RLSRPSRG 118
    Length:118
    Mass (Da):13,604
    Last modified:June 16, 2009 - v1
    Checksum:iC424F10C9C34DDE0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001233 Genomic DNA. Translation: ACP04343.1.
    RefSeqiYP_002808794.1. NC_012578.1.

    Genome annotation databases

    EnsemblBacteriaiACP04343; ACP04343; VCM66_0006.
    GeneIDi7771304.
    KEGGivcm:VCM66_0006.
    PATRICi20063753. VBIVibCho108967_0005.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001233 Genomic DNA. Translation: ACP04343.1 .
    RefSeqi YP_002808794.1. NC_012578.1.

    3D structure databases

    ProteinModelPortali C3LP79.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 579112.VCM66_0006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACP04343 ; ACP04343 ; VCM66_0006 .
    GeneIDi 7771304.
    KEGGi vcm:VCM66_0006.
    PATRICi 20063753. VBIVibCho108967_0005.

    Phylogenomic databases

    eggNOGi COG0594.
    HOGENOMi HOG000266301.
    KOi K03536.
    OMAi PPMDFVV.
    OrthoDBi EOG6C01C6.

    Enzyme and pathway databases

    BioCyci VCHO579112:GJAW-6-MONOMER.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    HAMAPi MF_00227. RNase_P.
    InterProi IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    IPR000100. RNase_P.
    [Graphical view ]
    Pfami PF00825. Ribonuclease_P. 1 hit.
    [Graphical view ]
    ProDomi PD003629. Ribonuclease_P. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF54211. SSF54211. 1 hit.
    TIGRFAMsi TIGR00188. rnpA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
      Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
      PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: M66-2.

    Entry informationi

    Entry nameiRNPA_VIBCM
    AccessioniPrimary (citable) accession number: C3LP79
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3