ID   C3LNA3_VIBCM            Unreviewed;       807 AA.
AC   C3LNA3;
DT   16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT   16-JUN-2009, sequence version 1.
DT   24-JAN-2024, entry version 76.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   Name=nanH {ECO:0000313|EMBL:ACP06029.1};
GN   OrderedLocusNames=VCM66_1722 {ECO:0000313|EMBL:ACP06029.1};
OS   Vibrio cholerae serotype O1 (strain M66-2).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=579112 {ECO:0000313|EMBL:ACP06029.1, ECO:0000313|Proteomes:UP000001217};
RN   [1] {ECO:0000313|EMBL:ACP06029.1, ECO:0000313|Proteomes:UP000001217}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M66-2 {ECO:0000313|EMBL:ACP06029.1,
RC   ECO:0000313|Proteomes:UP000001217};
RX   PubMed=19115014; DOI=10.1371/journal.pone.0004053;
RA   Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J.,
RA   Wang W., Wang J., Qian W., Li D., Wang L.;
RT   "A recalibrated molecular clock and independent origins for the cholera
RT   pandemic clones.";
RL   PLoS ONE 3:E4053-E4053(2008).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC       {ECO:0000256|ARBA:ARBA00009348}.
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DR   EMBL; CP001233; ACP06029.1; -; Genomic_DNA.
DR   AlphaFoldDB; C3LNA3; -.
DR   CAZy; CBM40; Carbohydrate-Binding Module Family 40.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   KEGG; vcm:VCM66_1722; -.
DR   HOGENOM; CLU_376807_0_0_6; -.
DR   PHI-base; PHI:8246; -.
DR   Proteomes; UP000001217; Chromosome I.
DR   GO; GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0033691; F:sialic acid binding; IEA:InterPro.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.120.200; -; 2.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR015344; VCNA_lectin-like_dom.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   Pfam; PF09264; Sial-lect-inser; 2.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000313|EMBL:ACP06029.1};
KW   Hydrolase {ECO:0000313|EMBL:ACP06029.1};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          91..243
FT                   /note="Vibrio cholerae neuraminidase lectin-like"
FT                   /evidence="ECO:0000259|Pfam:PF09264"
FT   DOMAIN          373..569
FT                   /note="Vibrio cholerae neuraminidase lectin-like"
FT                   /evidence="ECO:0000259|Pfam:PF09264"
FT   DOMAIN          580..772
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
SQ   SEQUENCE   807 AA;  88581 MW;  CE720E23598F9DCC CRC64;
     MSIKMTSQRR RASIHKETDS NIKGVDMRFK NVKKTALMLA MFGMATSSNA ALFDYNATGD
     TEFDSPAKQG WMQDNTNNGS GVLTNADGMP AWLVQGIGGR AQWTYSLSTN QHAQASSFGW
     RMTTEMKVLS GGMITNYYAN GTQRVLPIIS LDSSGNLVVE FEGQTGRTVL ATGTAATEYH
     KFELVFLPGS NPSASFYFDG KLIRDNIQPT ASKQNMIVWG NGSSNTDGVA AYRDIKFEIQ
     GDVIFRGPDR IPSIVASSVT PGVVTAFAEK RVGGGDPGAL SNTNDIITRT SRDGGITWDT
     ELNLTEQINV SDEFDFSDPR PIYDPSSNTV LVSYARWPTD AAQNGDRIKP WMPNGIFYSV
     YDVASGNWQA PIDVTDQVKE RSFQIAGWGG SELYRRNTSL NSQQDWQSNA KIRIVDGAAN
     QIQVADGSRK YVVTLSIDES GGLVANLNGV SAPIILQSEH AKVHSFHDYE LQYSALNHTT
     TLFVDGQQIT TWAGEVSQEN NIQFGNADAQ IDGRLHVQKI VLTQQGHNLV EFDAFYLAQQ
     TPEVEKDLEK LGWTKIKTGN TMSLYGNASV NPGPGHGITL TRQQNISGSQ NGRLIYPAIV
     LDRFFLNVMS IYSDDGGSNW QTGSTLPIPF RWKSSSILET LEPSEADMVE LQNGDLLLTA
     RLDFNQIVNG VNYSPRQQFL SKDGGITWSL LEANNANVFS NISTGTVDAS ITRFEQSDGS
     HFLLFTNPQG NPAGTNGRQN LGLWFSFDEG VTWKGPIQLV NGASAYSDIY QLDSENAIVI
     VETDNSNMRI LRMPITLLKQ KLTLSQN
//