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C3LM07

- C3LM07_VIBCM

UniProt

C3LM07 - C3LM07_VIBCM

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Protein

Alanine racemase

Gene
VCM66_1267
Organism
Vibrio cholerae serotype O1 (strain M66-2)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei95 – 951Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei194 – 1941Substrate By similarityUniRule annotation
Active sitei320 – 3201Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei368 – 3681Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotations

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciVCHO579112:GJAW-1333-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:VCM66_1267Imported
OrganismiVibrio cholerae serotype O1 (strain M66-2)Imported
Taxonomic identifieri579112 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000001217: Chromosome I

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei95 – 951N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi579112.VCM66_1267.

Structurei

3D structure databases

ProteinModelPortaliC3LM07.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000279190.
KOiK01775.
OMAiQQIPCVA.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3LM07-1 [UniParc]FASTAAdd to Basket

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MEQPLLSRKK NVPSMITTGD IMHFKATLLS LSIAATLPSF SLSAAPLHID    50
TALPDAAQIQ QSNSWLEISL GQFQSNIEQF KSHMNANTKI CAIMKADAYG 100
NGIRGLMPTI IAQGIPCVGV ASNAEARAVR ESGFKGELIR VRSASLSEMS 150
SALDLNIEEL IGTHQQALDL AELAKQSGKT LKVHIALNDG GMGRNGIDMT 200
TEAGKKEAVS IATQPSLSVV GIMTHFPNYN ADEVRAKLAQ FKESSTWLMQ 250
QANLKREEIT LHVANSYTAL NVPEAQLDMV RPGGVLFGDL PTNPEYPSIV 300
SFKTRVSSLH HLPKDSTVGY DSTFTTSRDS VLANLPVGYS DGYPRKMGNK 350
AEVLINGQRA KVVGVTSMNT TVVDVTEIKG VLPGQEVVLF GQQQKQSIAV 400
SEMENNAELI FPELYTLWGT SNPRFYVK 428
Length:428
Mass (Da):46,407
Last modified:June 16, 2009 - v1
Checksum:i2FD8D39D89537530
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001233 Genomic DNA. Translation: ACP05583.1.
RefSeqiYP_002810034.1. NC_012578.1.

Genome annotation databases

EnsemblBacteriaiACP05583; ACP05583; VCM66_1267.
GeneIDi7772544.
KEGGivcm:VCM66_1267.
PATRICi20066317. VBIVibCho108967_1209.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001233 Genomic DNA. Translation: ACP05583.1 .
RefSeqi YP_002810034.1. NC_012578.1.

3D structure databases

ProteinModelPortali C3LM07.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 579112.VCM66_1267.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACP05583 ; ACP05583 ; VCM66_1267 .
GeneIDi 7772544.
KEGGi vcm:VCM66_1267.
PATRICi 20066317. VBIVibCho108967_1209.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000279190.
KOi K01775.
OMAi QQIPCVA.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci VCHO579112:GJAW-1333-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
    Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
    PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M66-2Imported.

Entry informationi

Entry nameiC3LM07_VIBCM
AccessioniPrimary (citable) accession number: C3LM07
Entry historyi
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: July 9, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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