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Protein

Asparagine--tRNA ligase

Gene

asnS

Organism
Vibrio cholerae serotype O1 (strain M66-2)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn).UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseUniRule annotation, Ligase

Keywords - Biological processi

Protein biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciVCHO579112:GJAW-1318-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Asparagine--tRNA ligaseUniRule annotationSAAS annotation (EC:6.1.1.22UniRule annotationSAAS annotation)
Alternative name(s):
Asparaginyl-tRNA synthetaseUniRule annotation
Gene namesi
Name:asnSUniRule annotationImported
Ordered Locus Names:VCM66_1252Imported
OrganismiVibrio cholerae serotype O1 (strain M66-2)Imported
Taxonomic identifieri579112 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000001217 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiC3LLZ2.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi579112.VCM66_1252.

Structurei

3D structure databases

ProteinModelPortaliC3LLZ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0017.
HOGENOMiHOG000226033.
KOiK01893.
OMAiAIHRFFH.
OrthoDBiEOG6ZSP6X.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00534. Asn_tRNA_synth.
InterProiIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR004522. Asn-tRNA-ligase.
IPR002312. Asp/Asn-tRNA-synth_IIb.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view]
PANTHERiPTHR22594. PTHR22594. 1 hit.
PTHR22594:SF6. PTHR22594:SF6. 1 hit.
PfamiPF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view]
PRINTSiPR01042. TRNASYNTHASP.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00457. asnS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3LLZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALGCLYIST ETVINMTYAP VNDVLSGKLA VDSEVTVRGW IRTRRDSKAG
60 70 80 90 100
ISFLAIYDGS CFNPIQAVVP NNLNNYDNEV LKLTTGCSVE VTGKIVESPA
110 120 130 140 150
SGQAFELAAS DVKVVGWVED ADTYPMAKTR HSIEYLREVA HLRPRTNVIG
160 170 180 190 200
AVARVRNCLA QAIHRFYHEQ GYFWVSAPLI TASDAEGAGE MFRVSTLDME
210 220 230 240 250
NLPRTDAGKV DYNQDFFGKE TFLTVSGQLN AEAYACAISK VYTFGPTFRA
260 270 280 290 300
ENSNTSRHLA EFWMVEPEVA FADLNTVAKL AEDMLKYVFK AVLAERRDDL
310 320 330 340 350
EFFNDRINNE VIARLEQFVE SDFAQVDYTD AIEILKNCGK TFEFPVEWGI
360 370 380 390 400
DLASEHERFL AEEHFKAPVI VKNYPKDIKA FYMRMNEDGK TVAAMDVLAP
410 420 430 440 450
GIGEIIGGSQ REERLDILDA RMREFGIDPE HMDWYRDLRR YGTVPHAGFG
460 470 480
LGFERLVSYV TGMGNVRDVI PFPRTPRSAS F
Length:481
Mass (Da):54,065
Last modified:June 16, 2009 - v1
Checksum:iE473289C857E4C41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001233 Genomic DNA. Translation: ACP05568.1.
RefSeqiWP_001881065.1. NC_012578.1.
YP_002810019.1. NC_012578.1.

Genome annotation databases

EnsemblBacteriaiACP05568; ACP05568; VCM66_1252.
KEGGivcm:VCM66_1252.
PATRICi20066285. VBIVibCho108967_1193.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001233 Genomic DNA. Translation: ACP05568.1.
RefSeqiWP_001881065.1. NC_012578.1.
YP_002810019.1. NC_012578.1.

3D structure databases

ProteinModelPortaliC3LLZ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi579112.VCM66_1252.

Proteomic databases

PRIDEiC3LLZ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACP05568; ACP05568; VCM66_1252.
KEGGivcm:VCM66_1252.
PATRICi20066285. VBIVibCho108967_1193.

Phylogenomic databases

eggNOGiCOG0017.
HOGENOMiHOG000226033.
KOiK01893.
OMAiAIHRFFH.
OrthoDBiEOG6ZSP6X.

Enzyme and pathway databases

BioCyciVCHO579112:GJAW-1318-MONOMER.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00534. Asn_tRNA_synth.
InterProiIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR004522. Asn-tRNA-ligase.
IPR002312. Asp/Asn-tRNA-synth_IIb.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view]
PANTHERiPTHR22594. PTHR22594. 1 hit.
PTHR22594:SF6. PTHR22594:SF6. 1 hit.
PfamiPF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view]
PRINTSiPR01042. TRNASYNTHASP.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00457. asnS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
    Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
    PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M66-2Imported.

Entry informationi

Entry nameiC3LLZ2_VIBCM
AccessioniPrimary (citable) accession number: C3LLZ2
Entry historyi
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: May 27, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.