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C3LLL5

- TRPA_VIBCM

UniProt

C3LLL5 - TRPA_VIBCM

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Protein
Tryptophan synthase alpha chain
Gene
trpA, VCM66_1124
Organism
Vibrio cholerae serotype O1 (strain M66-2)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate By similarity.UniRule annotation

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei49 – 491Proton acceptor By similarity
Active sitei60 – 601Proton acceptor By similarity

GO - Molecular functioni

  1. tryptophan synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciVCHO579112:GJAW-1186-MONOMER.
UniPathwayiUPA00035; UER00044.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase alpha chain (EC:4.2.1.20)
Gene namesi
Name:trpA
Ordered Locus Names:VCM66_1124
OrganismiVibrio cholerae serotype O1 (strain M66-2)
Taxonomic identifieri579112 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000001217: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268Tryptophan synthase alpha chainUniRule annotation
PRO_1000198733Add
BLAST

Proteomic databases

PRIDEiC3LLL5.

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains By similarity.

Protein-protein interaction databases

STRINGi579112.VCM66_1124.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1311
Beta strandi18 – 247
Helixi30 – 4213
Beta strandi46 – 516
Helixi57 – 593
Helixi63 – 7311
Helixi78 – 9114
Beta strandi97 – 1015
Helixi103 – 1086
Helixi111 – 12111
Beta strandi125 – 1284
Helixi133 – 1353
Helixi137 – 1459
Beta strandi149 – 1546
Helixi160 – 16910
Beta strandi174 – 1763
Helixi191 – 20212
Beta strandi208 – 2103
Helixi217 – 2259
Beta strandi229 – 2346
Helixi235 – 2439
Turni244 – 2463
Helixi248 – 26417

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NAVX-ray2.10A/B1-268[»]
ProteinModelPortaliC3LLL5.
SMRiC3LLL5. Positions 1-267.

Miscellaneous databases

EvolutionaryTraceiC3LLL5.

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpA family.

Phylogenomic databases

eggNOGiCOG0159.
HOGENOMiHOG000223814.
KOiK01695.
OMAiRHEGAFV.
OrthoDBiEOG6RVG0K.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00131. Trp_synth_alpha.
InterProiIPR013785. Aldolase_TIM.
IPR011060. RibuloseP-bd_barrel.
IPR018204. Trp_synthase_alpha_AS.
IPR002028. Trp_synthase_suA.
[Graphical view]
PfamiPF00290. Trp_syntA. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR00262. trpA. 1 hit.
PROSITEiPS00167. TRP_SYNTHASE_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3LLL5-1 [UniParc]FASTAAdd to Basket

« Hide

MNRYQALFQR LSAAQQGAFV PFVTIGDPNP EQSLAIMQTL IDAGADALEL    50
GMPFSDPLAD GPTIQGANLR ALAAKTTPDI CFELIAQIRA RNPETPIGLL 100
MYANLVYARG IDDFYQRCQK AGVDSVLIAD VPTNESQPFV AAAEKFGIQP 150
IFIAPPTASD ETLRAVAQLG KGYTYLLSRA GVTGAETKAN MPVHALLERL 200
QQFDAPPALL GFGISEPAQV KQAIEAGAAG AISGSAVVKI IETHLDNPAK 250
QLTELANFTQ AMKKATKI 268
Length:268
Mass (Da):28,494
Last modified:June 16, 2009 - v1
Checksum:iA04BEA6FAEECB028
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001233 Genomic DNA. Translation: ACP05441.1.
RefSeqiYP_002809892.1. NC_012578.1.

Genome annotation databases

EnsemblBacteriaiACP05441; ACP05441; VCM66_1124.
GeneIDi7772402.
KEGGivcm:VCM66_1124.
PATRICi20066039. VBIVibCho108967_1074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001233 Genomic DNA. Translation: ACP05441.1 .
RefSeqi YP_002809892.1. NC_012578.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3NAV X-ray 2.10 A/B 1-268 [» ]
ProteinModelPortali C3LLL5.
SMRi C3LLL5. Positions 1-267.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 579112.VCM66_1124.

Proteomic databases

PRIDEi C3LLL5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACP05441 ; ACP05441 ; VCM66_1124 .
GeneIDi 7772402.
KEGGi vcm:VCM66_1124.
PATRICi 20066039. VBIVibCho108967_1074.

Phylogenomic databases

eggNOGi COG0159.
HOGENOMi HOG000223814.
KOi K01695.
OMAi RHEGAFV.
OrthoDBi EOG6RVG0K.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00044 .
BioCyci VCHO579112:GJAW-1186-MONOMER.

Miscellaneous databases

EvolutionaryTracei C3LLL5.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00131. Trp_synth_alpha.
InterProi IPR013785. Aldolase_TIM.
IPR011060. RibuloseP-bd_barrel.
IPR018204. Trp_synthase_alpha_AS.
IPR002028. Trp_synthase_suA.
[Graphical view ]
Pfami PF00290. Trp_syntA. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR00262. trpA. 1 hit.
PROSITEi PS00167. TRP_SYNTHASE_ALPHA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
    Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
    PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M66-2.

Entry informationi

Entry nameiTRPA_VIBCM
AccessioniPrimary (citable) accession number: C3LLL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: May 14, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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