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C3LLL5

- TRPA_VIBCM

UniProt

C3LLL5 - TRPA_VIBCM

Protein

Tryptophan synthase alpha chain

Gene

trpA

Organism
Vibrio cholerae serotype O1 (strain M66-2)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.UniRule annotation

    Catalytic activityi

    L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei49 – 491Proton acceptorUniRule annotation
    Active sitei60 – 601Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. tryptophan synthase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Enzyme and pathway databases

    BioCyciVCHO579112:GJAW-1186-MONOMER.
    UniPathwayiUPA00035; UER00044.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan synthase alpha chainUniRule annotation (EC:4.2.1.20UniRule annotation)
    Gene namesi
    Name:trpAUniRule annotation
    Ordered Locus Names:VCM66_1124
    OrganismiVibrio cholerae serotype O1 (strain M66-2)
    Taxonomic identifieri579112 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000001217: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 268268Tryptophan synthase alpha chainPRO_1000198733Add
    BLAST

    Proteomic databases

    PRIDEiC3LLL5.

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta chains.UniRule annotation

    Protein-protein interaction databases

    STRINGi579112.VCM66_1124.

    Structurei

    Secondary structure

    1
    268
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi3 – 1311
    Beta strandi18 – 247
    Helixi30 – 4213
    Beta strandi46 – 516
    Helixi57 – 593
    Helixi63 – 7311
    Helixi78 – 9114
    Beta strandi97 – 1015
    Helixi103 – 1086
    Helixi111 – 12111
    Beta strandi125 – 1284
    Helixi133 – 1353
    Helixi137 – 1459
    Beta strandi149 – 1546
    Helixi160 – 16910
    Beta strandi174 – 1763
    Helixi191 – 20212
    Beta strandi208 – 2103
    Helixi217 – 2259
    Beta strandi229 – 2346
    Helixi235 – 2439
    Turni244 – 2463
    Helixi248 – 26417

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3NAVX-ray2.10A/B1-268[»]
    ProteinModelPortaliC3LLL5.
    SMRiC3LLL5. Positions 1-267.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiC3LLL5.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TrpA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0159.
    HOGENOMiHOG000223814.
    KOiK01695.
    OMAiRHEGAFV.
    OrthoDBiEOG6RVG0K.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00131. Trp_synth_alpha.
    InterProiIPR013785. Aldolase_TIM.
    IPR011060. RibuloseP-bd_barrel.
    IPR018204. Trp_synthase_alpha_AS.
    IPR002028. Trp_synthase_suA.
    [Graphical view]
    PfamiPF00290. Trp_syntA. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR00262. trpA. 1 hit.
    PROSITEiPS00167. TRP_SYNTHASE_ALPHA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C3LLL5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNRYQALFQR LSAAQQGAFV PFVTIGDPNP EQSLAIMQTL IDAGADALEL    50
    GMPFSDPLAD GPTIQGANLR ALAAKTTPDI CFELIAQIRA RNPETPIGLL 100
    MYANLVYARG IDDFYQRCQK AGVDSVLIAD VPTNESQPFV AAAEKFGIQP 150
    IFIAPPTASD ETLRAVAQLG KGYTYLLSRA GVTGAETKAN MPVHALLERL 200
    QQFDAPPALL GFGISEPAQV KQAIEAGAAG AISGSAVVKI IETHLDNPAK 250
    QLTELANFTQ AMKKATKI 268
    Length:268
    Mass (Da):28,494
    Last modified:June 16, 2009 - v1
    Checksum:iA04BEA6FAEECB028
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001233 Genomic DNA. Translation: ACP05441.1.
    RefSeqiYP_002809892.1. NC_012578.1.

    Genome annotation databases

    EnsemblBacteriaiACP05441; ACP05441; VCM66_1124.
    GeneIDi7772402.
    KEGGivcm:VCM66_1124.
    PATRICi20066039. VBIVibCho108967_1074.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001233 Genomic DNA. Translation: ACP05441.1 .
    RefSeqi YP_002809892.1. NC_012578.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3NAV X-ray 2.10 A/B 1-268 [» ]
    ProteinModelPortali C3LLL5.
    SMRi C3LLL5. Positions 1-267.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 579112.VCM66_1124.

    Proteomic databases

    PRIDEi C3LLL5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACP05441 ; ACP05441 ; VCM66_1124 .
    GeneIDi 7772402.
    KEGGi vcm:VCM66_1124.
    PATRICi 20066039. VBIVibCho108967_1074.

    Phylogenomic databases

    eggNOGi COG0159.
    HOGENOMi HOG000223814.
    KOi K01695.
    OMAi RHEGAFV.
    OrthoDBi EOG6RVG0K.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00044 .
    BioCyci VCHO579112:GJAW-1186-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei C3LLL5.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00131. Trp_synth_alpha.
    InterProi IPR013785. Aldolase_TIM.
    IPR011060. RibuloseP-bd_barrel.
    IPR018204. Trp_synthase_alpha_AS.
    IPR002028. Trp_synthase_suA.
    [Graphical view ]
    Pfami PF00290. Trp_syntA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR00262. trpA. 1 hit.
    PROSITEi PS00167. TRP_SYNTHASE_ALPHA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
      Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
      PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: M66-2.

    Entry informationi

    Entry nameiTRPA_VIBCM
    AccessioniPrimary (citable) accession number: C3LLL5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3