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C3LLL5

- TRPA_VIBCM

UniProt

C3LLL5 - TRPA_VIBCM

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Protein

Tryptophan synthase alpha chain

Gene

trpA

Organism
Vibrio cholerae serotype O1 (strain M66-2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.UniRule annotation

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei49 – 491Proton acceptorUniRule annotation
Active sitei60 – 601Proton acceptorUniRule annotation

GO - Molecular functioni

  1. tryptophan synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciVCHO579112:GJAW-1186-MONOMER.
UniPathwayiUPA00035; UER00044.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase alpha chainUniRule annotation (EC:4.2.1.20UniRule annotation)
Gene namesi
Name:trpAUniRule annotation
Ordered Locus Names:VCM66_1124
OrganismiVibrio cholerae serotype O1 (strain M66-2)
Taxonomic identifieri579112 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000001217: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268Tryptophan synthase alpha chainPRO_1000198733Add
BLAST

Proteomic databases

PRIDEiC3LLL5.

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.UniRule annotation

Protein-protein interaction databases

STRINGi579112.VCM66_1124.

Structurei

3D structure databases

ProteinModelPortaliC3LLL5.
SMRiC3LLL5. Positions 1-267.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiC3LLL5.

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0159.
HOGENOMiHOG000223814.
KOiK01695.
OMAiRHEGAFV.
OrthoDBiEOG6RVG0K.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00131. Trp_synth_alpha.
InterProiIPR013785. Aldolase_TIM.
IPR011060. RibuloseP-bd_barrel.
IPR018204. Trp_synthase_alpha_AS.
IPR002028. Trp_synthase_suA.
[Graphical view]
PfamiPF00290. Trp_syntA. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR00262. trpA. 1 hit.
PROSITEiPS00167. TRP_SYNTHASE_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3LLL5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNRYQALFQR LSAAQQGAFV PFVTIGDPNP EQSLAIMQTL IDAGADALEL
60 70 80 90 100
GMPFSDPLAD GPTIQGANLR ALAAKTTPDI CFELIAQIRA RNPETPIGLL
110 120 130 140 150
MYANLVYARG IDDFYQRCQK AGVDSVLIAD VPTNESQPFV AAAEKFGIQP
160 170 180 190 200
IFIAPPTASD ETLRAVAQLG KGYTYLLSRA GVTGAETKAN MPVHALLERL
210 220 230 240 250
QQFDAPPALL GFGISEPAQV KQAIEAGAAG AISGSAVVKI IETHLDNPAK
260
QLTELANFTQ AMKKATKI
Length:268
Mass (Da):28,494
Last modified:June 16, 2009 - v1
Checksum:iA04BEA6FAEECB028
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001233 Genomic DNA. Translation: ACP05441.1.
RefSeqiYP_002809892.1. NC_012578.1.

Genome annotation databases

EnsemblBacteriaiACP05441; ACP05441; VCM66_1124.
GeneIDi7772402.
KEGGivcm:VCM66_1124.
PATRICi20066039. VBIVibCho108967_1074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001233 Genomic DNA. Translation: ACP05441.1 .
RefSeqi YP_002809892.1. NC_012578.1.

3D structure databases

ProteinModelPortali C3LLL5.
SMRi C3LLL5. Positions 1-267.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 579112.VCM66_1124.

Proteomic databases

PRIDEi C3LLL5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACP05441 ; ACP05441 ; VCM66_1124 .
GeneIDi 7772402.
KEGGi vcm:VCM66_1124.
PATRICi 20066039. VBIVibCho108967_1074.

Phylogenomic databases

eggNOGi COG0159.
HOGENOMi HOG000223814.
KOi K01695.
OMAi RHEGAFV.
OrthoDBi EOG6RVG0K.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00044 .
BioCyci VCHO579112:GJAW-1186-MONOMER.

Miscellaneous databases

EvolutionaryTracei C3LLL5.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00131. Trp_synth_alpha.
InterProi IPR013785. Aldolase_TIM.
IPR011060. RibuloseP-bd_barrel.
IPR018204. Trp_synthase_alpha_AS.
IPR002028. Trp_synthase_suA.
[Graphical view ]
Pfami PF00290. Trp_syntA. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR00262. trpA. 1 hit.
PROSITEi PS00167. TRP_SYNTHASE_ALPHA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
    Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
    PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M66-2.

Entry informationi

Entry nameiTRPA_VIBCM
AccessioniPrimary (citable) accession number: C3LLL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: November 26, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3