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Protein

Thymidylate kinase

Gene

tmk

Organism
Bacillus anthracis (strain CDC 684 / NRRL 3495)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotation
Ordered Locus Names:BAMEG_0039
OrganismiBacillus anthracis (strain CDC 684 / NRRL 3495)
Taxonomic identifieri568206 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001235561 – 208Thymidylate kinaseAdd BLAST208

Structurei

3D structure databases

ProteinModelPortaliC3LJ02.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229078.
KOiK00943.
OMAiGGIDIAE.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3LJ02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGLFVTIEG PEGSGKTTLI QSLLPYFEQK EQKVMATREP GGIAISEDIR
60 70 80 90 100
TILHKQEYTM MEARTEALLY AAARRQHLVE KVMPALNEDY LVLCDRFIDS
110 120 130 140 150
SLAYQGYARG LGMDKVFEIN RFATEDCMPS LTIYLDIEPE VGLARIAKDA
160 170 180 190 200
GREVNRLDME DISFHKRVRE GYLQVVERFS DRIVLVNADQ PMEKLIEEVI

QVIEDKLL
Length:208
Mass (Da):23,804
Last modified:June 16, 2009 - v1
Checksum:i8D12E4607E91067D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001215 Genomic DNA. Translation: ACP13366.1.
RefSeqiWP_000677237.1. NC_012581.1.

Genome annotation databases

EnsemblBacteriaiACP13366; ACP13366; BAMEG_0039.
KEGGibah:BAMEG_0039.
PATRICi18789804. VBIBacAnt127120_0332.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001215 Genomic DNA. Translation: ACP13366.1.
RefSeqiWP_000677237.1. NC_012581.1.

3D structure databases

ProteinModelPortaliC3LJ02.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACP13366; ACP13366; BAMEG_0039.
KEGGibah:BAMEG_0039.
PATRICi18789804. VBIBacAnt127120_0332.

Phylogenomic databases

HOGENOMiHOG000229078.
KOiK00943.
OMAiGGIDIAE.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKTHY_BACAC
AccessioniPrimary (citable) accession number: C3LJ02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: November 2, 2016
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.