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C3LAV7

- TRPA_BACAC

UniProt

C3LAV7 - TRPA_BACAC

Protein

Tryptophan synthase alpha chain

Gene

trpA

Organism
Bacillus anthracis (strain CDC 684 / NRRL 3495)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.UniRule annotation

    Catalytic activityi

    L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei47 – 471Proton acceptorUniRule annotation
    Active sitei58 – 581Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. tryptophan synthase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Enzyme and pathway databases

    BioCyciBANT568206:GHVT-3292-MONOMER.
    UniPathwayiUPA00035; UER00044.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan synthase alpha chainUniRule annotation (EC:4.2.1.20UniRule annotation)
    Gene namesi
    Name:trpAUniRule annotation
    Ordered Locus Names:BAMEG_3336
    OrganismiBacillus anthracis (strain CDC 684 / NRRL 3495)
    Taxonomic identifieri568206 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000007965: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 258258Tryptophan synthase alpha chainPRO_1000198699Add
    BLAST

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta chains.UniRule annotation

    Protein-protein interaction databases

    STRINGi568206.BAMEG_3336.

    Structurei

    3D structure databases

    ProteinModelPortaliC3LAV7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TrpA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0159.
    HOGENOMiHOG000223816.
    KOiK01695.
    OMAiHECALIP.
    OrthoDBiEOG6RVG0K.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00131. Trp_synth_alpha.
    InterProiIPR013785. Aldolase_TIM.
    IPR011060. RibuloseP-bd_barrel.
    IPR018204. Trp_synthase_alpha_AS.
    IPR002028. Trp_synthase_suA.
    [Graphical view]
    PfamiPF00290. Trp_syntA. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR00262. trpA. 1 hit.
    PROSITEiPS00167. TRP_SYNTHASE_ALPHA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C3LAV7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGVERIKAAF ENGKKAFIPY VMGGDGGLEI LKERIRFLDE AGASIVEIGI    50
    PFSDPVADGP TIQRAGKRAL DSGVTVKGIF QALIEVRKEV QIPFVLMTYL 100
    NPVLAFGKER FIENCMEAGV DGIIVPDLPY EEQDIIAPLL REANIALIPL 150
    VTVTSPIERI KKITSESEGF VYAVTVAGVT GVRQNFKDEI HSYLEKVKSH 200
    THLPVVAGFG ISTKEHVEEM VTICDGVVVG SKVIELLENE KREEICEFIQ 250
    ATKQKEEA 258
    Length:258
    Mass (Da):28,355
    Last modified:June 16, 2009 - v1
    Checksum:i78A7946B146004EF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001215 Genomic DNA. Translation: ACP13819.1.
    RefSeqiYP_002815919.1. NC_012581.1.

    Genome annotation databases

    EnsemblBacteriaiACP13819; ACP13819; BAMEG_3336.
    GeneIDi7785609.
    KEGGibah:BAMEG_3336.
    PATRICi18796476. VBIBacAnt127120_3613.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001215 Genomic DNA. Translation: ACP13819.1 .
    RefSeqi YP_002815919.1. NC_012581.1.

    3D structure databases

    ProteinModelPortali C3LAV7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 568206.BAMEG_3336.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACP13819 ; ACP13819 ; BAMEG_3336 .
    GeneIDi 7785609.
    KEGGi bah:BAMEG_3336.
    PATRICi 18796476. VBIBacAnt127120_3613.

    Phylogenomic databases

    eggNOGi COG0159.
    HOGENOMi HOG000223816.
    KOi K01695.
    OMAi HECALIP.
    OrthoDBi EOG6RVG0K.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00044 .
    BioCyci BANT568206:GHVT-3292-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00131. Trp_synth_alpha.
    InterProi IPR013785. Aldolase_TIM.
    IPR011060. RibuloseP-bd_barrel.
    IPR018204. Trp_synthase_alpha_AS.
    IPR002028. Trp_synthase_suA.
    [Graphical view ]
    Pfami PF00290. Trp_syntA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR00262. trpA. 1 hit.
    PROSITEi PS00167. TRP_SYNTHASE_ALPHA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Bacillus anthracis str. CDC 684."
      Dodson R.J., Munk A.C., Brettin T., Bruce D., Detter C., Tapia R., Han C., Sutton G., Sims D.
      Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CDC 684 / NRRL 3495.

    Entry informationi

    Entry nameiTRPA_BACAC
    AccessioniPrimary (citable) accession number: C3LAV7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3