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C3LAV7 (TRPA_BACAC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan synthase alpha chain

EC=4.2.1.20
Gene names
Name:trpA
Ordered Locus Names:BAMEG_3336
OrganismBacillus anthracis (strain CDC 684 / NRRL 3495) [Complete proteome] [HAMAP]
Taxonomic identifier568206 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate By similarity. HAMAP-Rule MF_00131

Catalytic activity

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O. HAMAP-Rule MF_00131

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5. HAMAP-Rule MF_00131

Subunit structure

Tetramer of two alpha and two beta chains By similarity.

Sequence similarities

Belongs to the TrpA family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functiontryptophan synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 258258Tryptophan synthase alpha chain HAMAP-Rule MF_00131
PRO_1000198699

Sites

Active site471Proton acceptor By similarity
Active site581Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
C3LAV7 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: 78A7946B146004EF

FASTA25828,355
        10         20         30         40         50         60 
MGVERIKAAF ENGKKAFIPY VMGGDGGLEI LKERIRFLDE AGASIVEIGI PFSDPVADGP 

        70         80         90        100        110        120 
TIQRAGKRAL DSGVTVKGIF QALIEVRKEV QIPFVLMTYL NPVLAFGKER FIENCMEAGV 

       130        140        150        160        170        180 
DGIIVPDLPY EEQDIIAPLL REANIALIPL VTVTSPIERI KKITSESEGF VYAVTVAGVT 

       190        200        210        220        230        240 
GVRQNFKDEI HSYLEKVKSH THLPVVAGFG ISTKEHVEEM VTICDGVVVG SKVIELLENE 

       250 
KREEICEFIQ ATKQKEEA 

« Hide

References

[1]"Genome sequence of Bacillus anthracis str. CDC 684."
Dodson R.J., Munk A.C., Brettin T., Bruce D., Detter C., Tapia R., Han C., Sutton G., Sims D.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CDC 684 / NRRL 3495.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001215 Genomic DNA. Translation: ACP13819.1.
RefSeqYP_002815919.1. NC_012581.1.

3D structure databases

ProteinModelPortalC3LAV7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING568206.BAMEG_3336.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACP13819; ACP13819; BAMEG_3336.
GeneID7785609.
KEGGbah:BAMEG_3336.
PATRIC18796476. VBIBacAnt127120_3613.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0159.
HOGENOMHOG000223816.
KOK01695.
OMAHECALIP.
OrthoDBEOG6RVG0K.

Enzyme and pathway databases

BioCycBANT568206:GHVT-3292-MONOMER.
UniPathwayUPA00035; UER00044.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00131. Trp_synth_alpha.
InterProIPR013785. Aldolase_TIM.
IPR011060. RibuloseP-bd_barrel.
IPR018204. Trp_synthase_alpha_AS.
IPR002028. Trp_synthase_suA.
[Graphical view]
PfamPF00290. Trp_syntA. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR00262. trpA. 1 hit.
PROSITEPS00167. TRP_SYNTHASE_ALPHA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRPA_BACAC
AccessionPrimary (citable) accession number: C3LAV7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways