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Protein

Tryptophan synthase alpha chain

Gene

trpA

Organism
Bacillus anthracis (strain CDC 684 / NRRL 3495)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.UniRule annotation

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei47 – 471Proton acceptorUniRule annotation
Active sitei58 – 581Proton acceptorUniRule annotation

GO - Molecular functioni

  1. tryptophan synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciBANT568206:GHVT-3292-MONOMER.
UniPathwayiUPA00035; UER00044.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase alpha chainUniRule annotation (EC:4.2.1.20UniRule annotation)
Gene namesi
Name:trpAUniRule annotation
Ordered Locus Names:BAMEG_3336
OrganismiBacillus anthracis (strain CDC 684 / NRRL 3495)
Taxonomic identifieri568206 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000007965 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Tryptophan synthase alpha chainPRO_1000198699Add
BLAST

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.UniRule annotation

Protein-protein interaction databases

STRINGi568206.BAMEG_3336.

Structurei

3D structure databases

ProteinModelPortaliC3LAV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0159.
HOGENOMiHOG000223816.
KOiK01695.
OMAiVFICPPN.
OrthoDBiEOG6RVG0K.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00131. Trp_synth_alpha.
InterProiIPR013785. Aldolase_TIM.
IPR011060. RibuloseP-bd_barrel.
IPR018204. Trp_synthase_alpha_AS.
IPR002028. Trp_synthase_suA.
[Graphical view]
PfamiPF00290. Trp_syntA. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR00262. trpA. 1 hit.
PROSITEiPS00167. TRP_SYNTHASE_ALPHA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3LAV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVERIKAAF ENGKKAFIPY VMGGDGGLEI LKERIRFLDE AGASIVEIGI
60 70 80 90 100
PFSDPVADGP TIQRAGKRAL DSGVTVKGIF QALIEVRKEV QIPFVLMTYL
110 120 130 140 150
NPVLAFGKER FIENCMEAGV DGIIVPDLPY EEQDIIAPLL REANIALIPL
160 170 180 190 200
VTVTSPIERI KKITSESEGF VYAVTVAGVT GVRQNFKDEI HSYLEKVKSH
210 220 230 240 250
THLPVVAGFG ISTKEHVEEM VTICDGVVVG SKVIELLENE KREEICEFIQ

ATKQKEEA
Length:258
Mass (Da):28,355
Last modified:June 16, 2009 - v1
Checksum:i78A7946B146004EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001215 Genomic DNA. Translation: ACP13819.1.
RefSeqiYP_002815919.1. NC_012581.1.

Genome annotation databases

EnsemblBacteriaiACP13819; ACP13819; BAMEG_3336.
KEGGibah:BAMEG_3336.
PATRICi18796476. VBIBacAnt127120_3613.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001215 Genomic DNA. Translation: ACP13819.1.
RefSeqiYP_002815919.1. NC_012581.1.

3D structure databases

ProteinModelPortaliC3LAV7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi568206.BAMEG_3336.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACP13819; ACP13819; BAMEG_3336.
KEGGibah:BAMEG_3336.
PATRICi18796476. VBIBacAnt127120_3613.

Phylogenomic databases

eggNOGiCOG0159.
HOGENOMiHOG000223816.
KOiK01695.
OMAiVFICPPN.
OrthoDBiEOG6RVG0K.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00044.
BioCyciBANT568206:GHVT-3292-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00131. Trp_synth_alpha.
InterProiIPR013785. Aldolase_TIM.
IPR011060. RibuloseP-bd_barrel.
IPR018204. Trp_synthase_alpha_AS.
IPR002028. Trp_synthase_suA.
[Graphical view]
PfamiPF00290. Trp_syntA. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR00262. trpA. 1 hit.
PROSITEiPS00167. TRP_SYNTHASE_ALPHA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Bacillus anthracis str. CDC 684."
    Dodson R.J., Munk A.C., Brettin T., Bruce D., Detter C., Tapia R., Han C., Sutton G., Sims D.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CDC 684 / NRRL 3495.

Entry informationi

Entry nameiTRPA_BACAC
AccessioniPrimary (citable) accession number: C3LAV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: April 1, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.