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Protein

Probable nicotinate-nucleotide adenylyltransferase

Gene

nadD

Organism
Bacillus anthracis (strain CDC 684 / NRRL 3495)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).UniRule annotation

Catalytic activityi

ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD+.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable nicotinate-nucleotide adenylyltransferase (nadD)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, NAD, Nucleotide-binding

Enzyme and pathway databases

BioCyciBANT568206:GHVT-4536-MONOMER.
BRENDAi2.7.7.18. 634.
UniPathwayiUPA00253; UER00332.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable nicotinate-nucleotide adenylyltransferaseUniRule annotation (EC:2.7.7.18UniRule annotation)
Alternative name(s):
Deamido-NAD(+) diphosphorylaseUniRule annotation
Deamido-NAD(+) pyrophosphorylaseUniRule annotation
Nicotinate mononucleotide adenylyltransferaseUniRule annotation
Short name:
NaMN adenylyltransferaseUniRule annotation
Gene namesi
Name:nadDUniRule annotation
Ordered Locus Names:BAMEG_4595
OrganismiBacillus anthracis (strain CDC 684 / NRRL 3495)
Taxonomic identifieri568206 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189Probable nicotinate-nucleotide adenylyltransferasePRO_1000125337Add
BLAST

Interactioni

Chemistry

BindingDBiC3L5T6.

Structurei

Secondary structure

1
189
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 97Combined sources
Helixi16 – 194Combined sources
Helixi23 – 286Combined sources
Beta strandi32 – 387Combined sources
Beta strandi45 – 473Combined sources
Helixi53 – 6412Combined sources
Beta strandi70 – 723Combined sources
Helixi76 – 783Combined sources
Beta strandi79 – 813Combined sources
Helixi85 – 9511Combined sources
Beta strandi100 – 1067Combined sources
Helixi107 – 1126Combined sources
Helixi113 – 1153Combined sources
Helixi119 – 1224Combined sources
Turni123 – 1253Combined sources
Beta strandi127 – 1315Combined sources
Beta strandi145 – 1473Combined sources
Helixi156 – 1649Combined sources
Turni170 – 1723Combined sources
Helixi175 – 1839Combined sources
Helixi186 – 1883Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QTRX-ray1.70A/B/C1-189[»]
3MLAX-ray1.75A/B1-189[»]
3MLBX-ray1.80A/B1-189[»]
3MMXX-ray2.55A/B/C/D/E/F/G/H1-189[»]
ProteinModelPortaliC3L5T6.
SMRiC3L5T6. Positions 1-189.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiC3L5T6.

Family & Domainsi

Sequence similaritiesi

Belongs to the NadD family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000262780.
KOiK00969.
OMAiHIETPYP.
OrthoDBiEOG6F55KJ.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00244. NaMN_adenylyltr.
InterProiIPR004821. Cyt_trans-like.
IPR005248. NAMN_adtrnsfrase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR12039. PTHR12039. 1 hit.
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00482. TIGR00482. 1 hit.

Sequencei

Sequence statusi: Complete.

C3L5T6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKIGIIGGT FDPPHYGHLL IANEVYHALN LEEVWFLPNQ IPPHKQGRNI
60 70 80 90 100
TSVESRLQML ELATEAEEHF SICLEELSRK GPSYTYDTML QLTKKYPDVQ
110 120 130 140 150
FHFIIGGDMV EYLPKWYNIE ALLDLVTFVG VARPGYKLRT PYPITTVEIP
160 170 180
EFAVSSSLLR ERYKEKKTCK YLLPEKVQVY IERNGLYES
Length:189
Mass (Da):21,955
Last modified:June 16, 2009 - v1
Checksum:iA26101CCE8549C53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001215 Genomic DNA. Translation: ACP12849.1.
RefSeqiWP_001226053.1. NC_012581.1.

Genome annotation databases

EnsemblBacteriaiACP12849; ACP12849; BAMEG_4595.
KEGGibah:BAMEG_4595.
PATRICi18799025. VBIBacAnt127120_4843.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001215 Genomic DNA. Translation: ACP12849.1.
RefSeqiWP_001226053.1. NC_012581.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QTRX-ray1.70A/B/C1-189[»]
3MLAX-ray1.75A/B1-189[»]
3MLBX-ray1.80A/B1-189[»]
3MMXX-ray2.55A/B/C/D/E/F/G/H1-189[»]
ProteinModelPortaliC3L5T6.
SMRiC3L5T6. Positions 1-189.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiC3L5T6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACP12849; ACP12849; BAMEG_4595.
KEGGibah:BAMEG_4595.
PATRICi18799025. VBIBacAnt127120_4843.

Phylogenomic databases

HOGENOMiHOG000262780.
KOiK00969.
OMAiHIETPYP.
OrthoDBiEOG6F55KJ.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00332.
BioCyciBANT568206:GHVT-4536-MONOMER.
BRENDAi2.7.7.18. 634.

Miscellaneous databases

EvolutionaryTraceiC3L5T6.
PROiC3L5T6.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00244. NaMN_adenylyltr.
InterProiIPR004821. Cyt_trans-like.
IPR005248. NAMN_adtrnsfrase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR12039. PTHR12039. 1 hit.
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00482. TIGR00482. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Bacillus anthracis str. CDC 684."
    Dodson R.J., Munk A.C., Brettin T., Bruce D., Detter C., Tapia R., Han C., Sutton G., Sims D.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CDC 684 / NRRL 3495.

Entry informationi

Entry nameiNADD_BACAC
AccessioniPrimary (citable) accession number: C3L5T6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: June 8, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.