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C3L2V1

- PUR5_CLOB6

UniProt

C3L2V1 - PUR5_CLOB6

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Clostridium botulinum (strain 657 / Type Ba4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBOT515621:GCP3-3095-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:CLJ_B3130
OrganismiClostridium botulinum (strain 657 / Type Ba4)
Taxonomic identifieri515621 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000002333: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000212817Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi515621.CLJ_B3130.

Structurei

3D structure databases

ProteinModelPortaliC3L2V1.
SMRiC3L2V1. Positions 17-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229091.
KOiK01933.
OMAiNPQENDI.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

C3L2V1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSYKEAGVN IEEGYKSVDL IKKHASKTFT KGVLNNLGSF AGMFELPKYK
60 70 80 90 100
NPVLVSGTDG VGTKLDIAFR MKKYNTVGID CVAMCVNDIL CHGAKPLFFL
110 120 130 140 150
DYIACGKLEA EVAAQLVEGV SNGCIQSECA LIGGETAEMP GFYRDGEYDI
160 170 180 190 200
AGFAVGVAEK DEIIDGSKIE DGDVLIGIAS SGPHSNGYSL IRKIVEDLHK
210 220 230 240 250
DFAGDKIGNT LLTPTKIYVK PVMKLLEKYN IKGMAHVTGG GFYENIPRMF
260 270 280 290 300
KEDFTAVINK KSYPVPNIFN HLMNLGVEED HMYNTFNMGI GFVLCVNEKD
310 320 330
GENIIKDLIE MGEKGYKIGY VKKGDKSVEL I
Length:331
Mass (Da):36,221
Last modified:June 16, 2009 - v1
Checksum:i808FF0EC4DD6CFCF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001083 Genomic DNA. Translation: ACQ51729.1.
RefSeqiYP_002863884.1. NC_012658.1.

Genome annotation databases

EnsemblBacteriaiACQ51729; ACQ51729; CLJ_B3130.
GeneIDi7880690.
KEGGicbi:CLJ_B3130.
PATRICi19414589. VBICloBot19908_3324.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001083 Genomic DNA. Translation: ACQ51729.1 .
RefSeqi YP_002863884.1. NC_012658.1.

3D structure databases

ProteinModelPortali C3L2V1.
SMRi C3L2V1. Positions 17-325.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 515621.CLJ_B3130.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ51729 ; ACQ51729 ; CLJ_B3130 .
GeneIDi 7880690.
KEGGi cbi:CLJ_B3130.
PATRICi 19414589. VBICloBot19908_3324.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229091.
KOi K01933.
OMAi NPQENDI.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci CBOT515621:GCP3-3095-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Clostridium botulinum Ba4 strain 657."
    Shrivastava S., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 657 / Type Ba4.

Entry informationi

Entry nameiPUR5_CLOB6
AccessioniPrimary (citable) accession number: C3L2V1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: October 29, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3