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C3L2U9 (PUR9_CLOB6) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:CLJ_B3128
OrganismClostridium botulinum (strain 657 / Type Ba4) [Complete proteome] [HAMAP]
Taxonomic identifier515621 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length499 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 499499Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_1000203247

Sequences

Sequence LengthMass (Da)Tools
C3L2U9 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: C48150565A5E9D47

FASTA49955,876
        10         20         30         40         50         60 
MIKRALISVF DKTGILDLAK FLESRDVEII STGGTYKHLK ENGVKVIDIE EVTGFPEMLD 

        70         80         90        100        110        120 
GRVKTLNPLI HGGILAIRDN EEHMKVIEEK GIKPIDMVVV NLYPFFNKVE EDLSFDEKVE 

       130        140        150        160        170        180 
FIDIGGPTMI RAAAKNFKDV VVLTDTKDYE NVINEIKENN QVNIKTKKKL AGKVFNLMSA 

       190        200        210        220        230        240 
YDAAISNFLL EEEYPEYLTL SYKKNMDLRY GENPHQTAAY YTSTVGKYPM KNFKKLNGKE 

       250        260        270        280        290        300 
LSYNNIKDMD IAWKTVCEFK EVACCALKHN TPCGVAIGDT IQEVYTKAYE CDPISIFGGI 

       310        320        330        340        350        360 
VAFNRKVDKE TAENLIKIFL EIVVAPDFDE DALEVLKTKK NLRVIKCEEK STQDKDMTKV 

       370        380        390        400        410        420 
DGGILVQQSD NKLLEDTKVV TEKSPTEKEM NDLIFGMKVV KYVKSNAIVV IKDGMAKGIG 

       430        440        450        460        470        480 
GGQVNRIWAA KEALDRAGDG VVLASDAFFP FGDVAEEAAK WGIKAIIQPG GSIRDEESIK 

       490 
VCNEKGISMV FTGVRHFKH 

« Hide

References

[1]"Genome sequence of Clostridium botulinum Ba4 strain 657."
Shrivastava S., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 657 / Type Ba4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001083 Genomic DNA. Translation: ACQ52198.1.
RefSeqYP_002863882.1. NC_012658.1.

3D structure databases

ProteinModelPortalC3L2U9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING515621.CLJ_B3128.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACQ52198; ACQ52198; CLJ_B3128.
GeneID7879958.
KEGGcbi:CLJ_B3128.
PATRIC19414585. VBICloBot19908_3322.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMAGIGQADN.
OrthoDBEOG6QCDFF.

Enzyme and pathway databases

BioCycCBOT515621:GCP3-3093-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_CLOB6
AccessionPrimary (citable) accession number: C3L2U9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways