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C3L2U9

- PUR9_CLOB6

UniProt

C3L2U9 - PUR9_CLOB6

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Clostridium botulinum (strain 657 / Type Ba4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciCBOT515621:GCP3-3093-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:CLJ_B3128
    OrganismiClostridium botulinum (strain 657 / Type Ba4)
    Taxonomic identifieri515621 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000002333: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 499499Bifunctional purine biosynthesis protein PurHPRO_1000203247Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi515621.CLJ_B3128.

    Structurei

    3D structure databases

    ProteinModelPortaliC3L2U9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiGIGQADN.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C3L2U9-1 [UniParc]FASTAAdd to Basket

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    MIKRALISVF DKTGILDLAK FLESRDVEII STGGTYKHLK ENGVKVIDIE    50
    EVTGFPEMLD GRVKTLNPLI HGGILAIRDN EEHMKVIEEK GIKPIDMVVV 100
    NLYPFFNKVE EDLSFDEKVE FIDIGGPTMI RAAAKNFKDV VVLTDTKDYE 150
    NVINEIKENN QVNIKTKKKL AGKVFNLMSA YDAAISNFLL EEEYPEYLTL 200
    SYKKNMDLRY GENPHQTAAY YTSTVGKYPM KNFKKLNGKE LSYNNIKDMD 250
    IAWKTVCEFK EVACCALKHN TPCGVAIGDT IQEVYTKAYE CDPISIFGGI 300
    VAFNRKVDKE TAENLIKIFL EIVVAPDFDE DALEVLKTKK NLRVIKCEEK 350
    STQDKDMTKV DGGILVQQSD NKLLEDTKVV TEKSPTEKEM NDLIFGMKVV 400
    KYVKSNAIVV IKDGMAKGIG GGQVNRIWAA KEALDRAGDG VVLASDAFFP 450
    FGDVAEEAAK WGIKAIIQPG GSIRDEESIK VCNEKGISMV FTGVRHFKH 499
    Length:499
    Mass (Da):55,876
    Last modified:June 16, 2009 - v1
    Checksum:iC48150565A5E9D47
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001083 Genomic DNA. Translation: ACQ52198.1.
    RefSeqiWP_003359898.1. NC_012658.1.
    YP_002863882.1. NC_012658.1.

    Genome annotation databases

    EnsemblBacteriaiACQ52198; ACQ52198; CLJ_B3128.
    GeneIDi7879958.
    KEGGicbi:CLJ_B3128.
    PATRICi19414585. VBICloBot19908_3322.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001083 Genomic DNA. Translation: ACQ52198.1 .
    RefSeqi WP_003359898.1. NC_012658.1.
    YP_002863882.1. NC_012658.1.

    3D structure databases

    ProteinModelPortali C3L2U9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 515621.CLJ_B3128.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACQ52198 ; ACQ52198 ; CLJ_B3128 .
    GeneIDi 7879958.
    KEGGi cbi:CLJ_B3128.
    PATRICi 19414585. VBICloBot19908_3322.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi GIGQADN.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci CBOT515621:GCP3-3093-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Clostridium botulinum Ba4 strain 657."
      Shrivastava S., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
      Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 657 / Type Ba4.

    Entry informationi

    Entry nameiPUR9_CLOB6
    AccessioniPrimary (citable) accession number: C3L2U9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3