C3L1M7 (C3L1M7_CLOB6) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Probable glycine dehydrogenase [decarboxylating] subunit 1 HAMAP-Rule MF_00712
EC=1.4.4.2 HAMAP-Rule MF_00712

Alternative name(s):
Glycine cleavage system P-protein subunit 1 HAMAP-Rule MF_00712
Glycine decarboxylase subunit 1 HAMAP-Rule MF_00712

Gene names

Name:	gcvPA HAMAP-Rule MF_00712 EMBL ACQ55102.1
Ordered Locus Names:	CLJ_B0770 EMBL ACQ55102.1

Organism

Clostridium botulinum (strain 657 / Type Ba4) [Complete proteome] [HAMAP] EMBL ACQ55102.1

Taxonomic identifier

515621 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium › Clostridium botulinum › Clostridium botulinum B

Protein attributes

Sequence length	446 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712 SAAS SAAS023010
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP-Rule MF_00712 SAAS SAAS023010
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity. HAMAP-Rule MF_00712 SAAS SAAS023010
Sequence similarities	Belongs to the GcvP family. N-terminal subunit subfamily. HAMAP-Rule MF_00712

Ontologies

Keywords
Molecular function	Oxidoreductase HAMAP-Rule MF_00712 SAAS SAAS023010 EMBL ACQ55102.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycine catabolic process Inferred from electronic annotation. Source: InterPro nucleoside metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C3L1M7 [UniParc]. Last modified June 16, 2009. Version 1. Checksum: FDA1D61713CC3251	FASTA	446	49,565
	10 20 30 40 50 60 MFPYIPNTEK ETKEILDFLS IKSIDELFSD IPDNLKLNRE LDLESSLSEL EVGKRLKALA 70 80 90 100 110 120 LKNKSMEDMT CFLGAGIYDH YIPSVIKHIT GRSEFYTAYT PYQPEVSQGT LQAIFEYQSM 130 140 150 160 170 180 ICALTGMEVS NSSMYDGATA TAEAAILSIV STKRNTIIVS KSVNLDTRKV LKTYLKYRGY 190 200 210 220 230 240 NMVEVDLEDG TTDVDKVINS LDKNVAAVII QSPNFLGLVE DVENMVDAIH KNKSLLIMNV 250 260 270 280 290 300 DPISLGILKS PGELGADIVV GDGQCLGANM SYGGPGFGFM NTTKKLMRKM PGRIVGETED 310 320 330 340 350 360 VEGKRGFVLT LQAREQHIRR EKATSNICSD QTAVAIGAAV YMATLGKEGV REVAKQCLAK 370 380 390 400 410 420 SHYAYNELIK SGKYKPVFNK PFFKEFVVKA ETSPCEINDK LLENNILGGY DLGKVYSEYE 430 440 NSMLLCVTEK RTREDIDNLV KVMEEI

References

[1]

"Genome sequence of Clostridium botulinum Ba4 strain 657." Shrivastava S., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S. Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 657 / Type Ba4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001083 Genomic DNA. Translation: ACQ55102.1.
RefSeq	YP_002861571.1. NC_012658.1.
3D structure databases
ProteinModelPortal	C3L1M7.
ModBase	Search...
Protein-protein interaction databases
STRING	515621.CLJ_B0770.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACQ55102; ACQ55102; CLJ_B0770.
GeneID	7878996.
KEGG	cbi:CLJ_B0770.
PATRIC	19409958. VBICloBot19908_1009.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0403.
HOGENOM	HOG000132025.
KO	K00282.
OMA	MYDGASA.
ProtClustDB	PRK00451.
Enzyme and pathway databases
BioCyc	CBOT515621:GCP3-753-MONOMER.
Family and domain databases
Gene3D	3.40.640.10. 1 hit.
HAMAP	MF_00712. GcvPA.
InterPro	IPR020580. GDC-P_N. IPR020581. GDC_P. IPR023010. GDC_P_su1. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
PANTHER	PTHR11773. PTHR11773. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
PIRSF	PIRSF006815. GcvPA. 1 hit.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C3L1M7_CLOB6

Accession

Primary (citable) accession number: C3L1M7

Entry history

Integrated into UniProtKB/TrEMBL:	June 16, 2009
Last sequence update:	June 16, 2009
Last modified:	May 29, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)