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C3L062

- THIM1_CLOB6

UniProt

C3L062 - THIM1_CLOB6

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Protein
Hydroxyethylthiazole kinase 1
Gene
thiM1, CLJ_B0522
Organism
Clostridium botulinum (strain 657 / Type Ba4)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421Substrate; via amide nitrogen By similarity
Binding sitei118 – 1181ATP By similarity
Binding sitei164 – 1641ATP By similarity
Binding sitei191 – 1911Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBOT515621:GCP3-508-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinase 1 (EC:2.7.1.50)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase 1
Short name:
TH kinase 1
Short name:
Thz kinase 1
Gene namesi
Name:thiM1
Ordered Locus Names:CLJ_B0522
OrganismiClostridium botulinum (strain 657 / Type Ba4)
Taxonomic identifieri515621 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000002333: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Hydroxyethylthiazole kinase 1UniRule annotation
PRO_0000383839Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi515621.CLJ_B0522.

Structurei

3D structure databases

ProteinModelPortaliC3L062.

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OMAiRICIQEV.
OrthoDBiEOG628F8M.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00694. thiM. 1 hit.

Sequencei

Sequence statusi: Complete.

C3L062-1 [UniParc]FASTAAdd to Basket

« Hide

MENKNVIQKM REKTPLIHCI TNYVTINDCA NILLSFGASP AMCEAYDEVY    50
DFVSISSALY INLGTLTKEQ ETAAVLASIS AKNHNVPVVI DPVGCPAIKR 100
KVEVINRMAE VGRIDIIKGN IGEIKFLAGM DSETRGVDSL DNGENALDAC 150
TQLAKKYNCI VAATGEKDFV SDGKRGSVIK NGTEMLTKVT GAGCMLGALC 200
AATCANFEDK LVSTTAAILS MNIAGEKAYE KAQLPGSFRI ALIDNIYMIS 250
DEEIWERGNV EWK 263
Length:263
Mass (Da):28,473
Last modified:June 16, 2009 - v1
Checksum:iCB2C16FB52E36336
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001083 Genomic DNA. Translation: ACQ51920.1.
RefSeqiWP_003359664.1. NC_012658.1.
YP_002861328.1. NC_012658.1.

Genome annotation databases

EnsemblBacteriaiACQ51920; ACQ51920; CLJ_B0522.
GeneIDi7877479.
KEGGicbi:CLJ_B0522.
PATRICi19409474. VBICloBot19908_0769.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001083 Genomic DNA. Translation: ACQ51920.1 .
RefSeqi WP_003359664.1. NC_012658.1.
YP_002861328.1. NC_012658.1.

3D structure databases

ProteinModelPortali C3L062.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 515621.CLJ_B0522.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ51920 ; ACQ51920 ; CLJ_B0522 .
GeneIDi 7877479.
KEGGi cbi:CLJ_B0522.
PATRICi 19409474. VBICloBot19908_0769.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OMAi RICIQEV.
OrthoDBi EOG628F8M.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci CBOT515621:GCP3-508-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00694. thiM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Clostridium botulinum Ba4 strain 657."
    Shrivastava S., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 657 / Type Ba4.

Entry informationi

Entry nameiTHIM1_CLOB6
AccessioniPrimary (citable) accession number: C3L062
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: September 3, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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