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C3L049

- PEPT_CLOB6

UniProt

C3L049 - PEPT_CLOB6

Protein

Peptidase T

Gene

pepT

Organism
Clostridium botulinum (strain 657 / Type Ba4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    Cleaves the N-terminal amino acid of tripeptides.UniRule annotation

    Catalytic activityi

    Release of the N-terminal residue from a tripeptide.UniRule annotation

    Cofactori

    Binds 2 zinc ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi78 – 781Zinc 1UniRule annotation
    Active sitei80 – 801UniRule annotation
    Metal bindingi141 – 1411Zinc 1UniRule annotation
    Metal bindingi141 – 1411Zinc 2UniRule annotation
    Active sitei175 – 1751Proton acceptorUniRule annotation
    Metal bindingi176 – 1761Zinc 2UniRule annotation
    Metal bindingi198 – 1981Zinc 1UniRule annotation
    Metal bindingi380 – 3801Zinc 2UniRule annotation

    GO - Molecular functioni

    1. metallopeptidase activity Source: UniProtKB-KW
    2. tripeptide aminopeptidase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptide metabolic process Source: InterPro

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciCBOT515621:GCP3-495-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidase TUniRule annotation (EC:3.4.11.4UniRule annotation)
    Alternative name(s):
    AminotripeptidaseUniRule annotation
    Short name:
    TripeptidaseUniRule annotation
    Tripeptide aminopeptidaseUniRule annotation
    Gene namesi
    Name:pepTUniRule annotation
    Ordered Locus Names:CLJ_B0509
    OrganismiClostridium botulinum (strain 657 / Type Ba4)
    Taxonomic identifieri515621 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000002333: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 408408Peptidase TPRO_1000211989Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi515621.CLJ_B0509.

    Structurei

    3D structure databases

    ProteinModelPortaliC3L049.
    SMRiC3L049. Positions 1-408.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M20B family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2195.
    HOGENOMiHOG000032390.
    KOiK01258.
    OMAiHENYDGE.
    OrthoDBiEOG6SV59Q.

    Family and domain databases

    Gene3Di3.30.70.360. 1 hit.
    HAMAPiMF_00550. Aminopeptidase_M20.
    InterProiIPR001261. ArgE/DapE_CS.
    IPR002933. Peptidase_M20.
    IPR011650. Peptidase_M20_dimer.
    IPR010161. Peptidase_M20B.
    [Graphical view]
    PfamiPF07687. M20_dimer. 1 hit.
    PF01546. Peptidase_M20. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037215. Peptidase_M20B. 1 hit.
    SUPFAMiSSF55031. SSF55031. 1 hit.
    TIGRFAMsiTIGR01882. peptidase-T. 1 hit.
    PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
    PS00759. ARGE_DAPE_CPG2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C3L049-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKDVLERFLG YIRIDTQSSE ESDTVPTTKT QLEFAKKLGE ELKAIGLKDV    50
    SVDENGYVMA TLESNIDKKV PTIGFIAHMD TSPDLSGTNI NPRIVEKYDG 100
    QDIVLNKEKN IVLKINEFPE ILEYKGQDIV VTDGNTLLGA DDKAGIAEII 150
    TAMEYLINHP EIKHGTIKVG FTPDEEVGKG ADHFDVKKFG ADLAYTLDGG 200
    GIGELECETF NAAKAKVIIE GRNVHPGSAK NKMTNAVLVA NKFINMLPEN 250
    EVPERTEGYE GFFHLLSVKS EVETAELNYI IRDFDRKKFE ERKEQIKEVG 300
    KKINEEYNKE IVCVKVEDQY YNMKEKIDEV KYVVDIAHDA MKAIDIEPIL 350
    VPIRGGTDGS RLSFMGLPTP NLFAGGHNFH GRFEFVPVLS MEKAAELVVK 400
    IAELYANR 408
    Length:408
    Mass (Da):45,624
    Last modified:June 16, 2009 - v1
    Checksum:i2694F24CE04969AC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001083 Genomic DNA. Translation: ACQ54839.1.
    RefSeqiYP_002861315.1. NC_012658.1.

    Genome annotation databases

    EnsemblBacteriaiACQ54839; ACQ54839; CLJ_B0509.
    GeneIDi7880723.
    KEGGicbi:CLJ_B0509.
    PATRICi19409448. VBICloBot19908_0756.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001083 Genomic DNA. Translation: ACQ54839.1 .
    RefSeqi YP_002861315.1. NC_012658.1.

    3D structure databases

    ProteinModelPortali C3L049.
    SMRi C3L049. Positions 1-408.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 515621.CLJ_B0509.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACQ54839 ; ACQ54839 ; CLJ_B0509 .
    GeneIDi 7880723.
    KEGGi cbi:CLJ_B0509.
    PATRICi 19409448. VBICloBot19908_0756.

    Phylogenomic databases

    eggNOGi COG2195.
    HOGENOMi HOG000032390.
    KOi K01258.
    OMAi HENYDGE.
    OrthoDBi EOG6SV59Q.

    Enzyme and pathway databases

    BioCyci CBOT515621:GCP3-495-MONOMER.

    Family and domain databases

    Gene3Di 3.30.70.360. 1 hit.
    HAMAPi MF_00550. Aminopeptidase_M20.
    InterProi IPR001261. ArgE/DapE_CS.
    IPR002933. Peptidase_M20.
    IPR011650. Peptidase_M20_dimer.
    IPR010161. Peptidase_M20B.
    [Graphical view ]
    Pfami PF07687. M20_dimer. 1 hit.
    PF01546. Peptidase_M20. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037215. Peptidase_M20B. 1 hit.
    SUPFAMi SSF55031. SSF55031. 1 hit.
    TIGRFAMsi TIGR01882. peptidase-T. 1 hit.
    PROSITEi PS00758. ARGE_DAPE_CPG2_1. 1 hit.
    PS00759. ARGE_DAPE_CPG2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Clostridium botulinum Ba4 strain 657."
      Shrivastava S., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
      Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 657 / Type Ba4.

    Entry informationi

    Entry nameiPEPT_CLOB6
    AccessioniPrimary (citable) accession number: C3L049
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3