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Protein

Putative D-threonate 4-phosphate dehydrogenase

Gene

pdxA

Organism
Clostridium botulinum (strain 657 / Type Ba4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP).By similarity

Catalytic activityi

4-phospho-D-threonate + NAD+ = glycerone phosphate + CO2 + NADH.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 1 divalent metal cation per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei141SubstrateBy similarity1
Binding sitei142SubstrateBy similarity1
Metal bindingi171Divalent metal cation; shared with dimeric partnerBy similarity1
Metal bindingi215Divalent metal cation; shared with dimeric partnerBy similarity1
Metal bindingi270Divalent metal cation; shared with dimeric partnerBy similarity1
Binding sitei278SubstrateBy similarity1
Binding sitei296SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism
LigandMetal-binding, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Putative D-threonate 4-phosphate dehydrogenaseBy similarity (EC:1.1.1.408By similarity)
Gene namesi
Name:pdxA
Ordered Locus Names:CLJ_B2416
OrganismiClostridium botulinum (strain 657 / Type Ba4)
Taxonomic identifieri515621 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002119101 – 334Putative D-threonate 4-phosphate dehydrogenaseAdd BLAST334

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliC3KYY3.
SMRiC3KYY3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family. PdxA2 subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000221593.
KOiK00097.
OMAiAPVHKGV.
OrthoDBiPOG091H03XD.

Family and domain databases

InterProiView protein in InterPro
IPR005255. PdxA.
PANTHERiPTHR30004. PTHR30004. 1 hit.
PfamiView protein in Pfam
PF04166. PdxA. 1 hit.
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

C3KYY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINNKPIIGI PIGDPAGVGP EIVVKSLTQA EIYEKCNPIL IGDAKVIKQA
60 70 80 90 100
MGFCNVNLNI NSIKKVDEGK FTLGTIDLID LNNIDIDELK IGKVQGIAGK
110 120 130 140 150
AAFEYIKKSV EMAKEGELDA IATTPINKES LREGNVNYIG HTEILADLTD
160 170 180 190 200
TEDPLTMFEV RGMRVFFLTR HVSLRKACDL VTKERVLDYI IRCSEALEKL
210 220 230 240 250
GVKDGKMAVA GLNPHSGEHG LFGDEEMKAV VPAIEEAQKM GYKVEGPIGA
260 270 280 290 300
DSVFHLALKG RYNSVLSLYH DQGHIATKTL DFERTIAVTN GMPILRTSVD
310 320 330
HGTAFDIAGT GQASSVSMVE AIILAAKYSP KFKK
Length:334
Mass (Da):36,314
Last modified:June 16, 2009 - v1
Checksum:i6E373CC452F25B1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001083 Genomic DNA. Translation: ACQ54394.1.
RefSeqiWP_012721219.1. NC_012658.1.

Genome annotation databases

EnsemblBacteriaiACQ54394; ACQ54394; CLJ_B2416.
KEGGicbi:CLJ_B2416.

Similar proteinsi

Entry informationi

Entry nameiPDXA2_CLOB6
AccessioniPrimary (citable) accession number: C3KYY3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: September 27, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families