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C3KXC0

- NADK_CLOB6

UniProt

C3KXC0 - NADK_CLOB6

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Protein

NAD kinase

Gene
nadK, CLJ_B2066
Organism
Clostridium botulinum (strain 657 / Type Ba4)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei61 – 611Proton acceptor By similarity
Binding sitei145 – 1451NAD By similarity
Binding sitei164 – 1641NAD By similarity
Binding sitei234 – 2341NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi61 – 622NAD By similarity
Nucleotide bindingi134 – 1352NAD By similarity
Nucleotide bindingi175 – 1806NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBOT515621:GCP3-2039-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:CLJ_B2066
OrganismiClostridium botulinum (strain 657 / Type Ba4)
Taxonomic identifieri515621 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000002333: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281NAD kinaseUniRule annotationPRO_1000205412Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi515621.CLJ_B2066.

Structurei

3D structure databases

ProteinModelPortaliC3KXC0.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
KOiK00858.
OMAiRWEALCL.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

C3KXC0-1 [UniParc]FASTAAdd to Basket

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MKNIGININT DKDISRNILD KIFQYIHEEC SEAKIKVFYD SKGLDNEESR    50
ALDAVMVLGG DGTILGTARA LAKYDVPIFG INRGHLGFLA EIELEDCKKA 100
IKNLFKGQYK IEDRIMLKCD LKGIDKKDDF LALNDIVLTK GNLSRIVKYS 150
IYVDDVWYTT FVADGVIVAT PTGSTAYSLS AGGPIVYPDL DVLEIAPICP 200
HSLGIRPILL NGNSKINIRV LKKYEDPVLT IDGQRYKKVT VNEVTISKSK 250
YKCRLIKFKD KDYFKILRTK ISYRSRECEG E 281
Length:281
Mass (Da):31,689
Last modified:June 16, 2009 - v1
Checksum:i829ECA8B8EE1A1AC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001083 Genomic DNA. Translation: ACQ53219.1.
RefSeqiYP_002862846.1. NC_012658.1.

Genome annotation databases

EnsemblBacteriaiACQ53219; ACQ53219; CLJ_B2066.
GeneIDi7878306.
KEGGicbi:CLJ_B2066.
PATRICi19412497. VBICloBot19908_2278.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001083 Genomic DNA. Translation: ACQ53219.1 .
RefSeqi YP_002862846.1. NC_012658.1.

3D structure databases

ProteinModelPortali C3KXC0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 515621.CLJ_B2066.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ53219 ; ACQ53219 ; CLJ_B2066 .
GeneIDi 7878306.
KEGGi cbi:CLJ_B2066.
PATRICi 19412497. VBICloBot19908_2278.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227222.
KOi K00858.
OMAi RWEALCL.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci CBOT515621:GCP3-2039-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Clostridium botulinum Ba4 strain 657."
    Shrivastava S., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 657 / Type Ba4.

Entry informationi

Entry nameiNADK_CLOB6
AccessioniPrimary (citable) accession number: C3KXC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: July 9, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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