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C3KVW3

- GCH1_CLOB6

UniProt

C3KVW3 - GCH1_CLOB6

Protein

GTP cyclohydrolase 1

Gene

folE

Organism
Clostridium botulinum (strain 657 / Type Ba4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi86 – 861ZincUniRule annotation
    Metal bindingi89 – 891ZincUniRule annotation
    Metal bindingi158 – 1581ZincUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
    2. one-carbon metabolic process Source: UniProtKB-HAMAP
    3. tetrahydrofolate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    GTP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciCBOT515621:GCP3-1641-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase 1UniRule annotation (EC:3.5.4.16UniRule annotation)
    Alternative name(s):
    GTP cyclohydrolase IUniRule annotation
    Short name:
    GTP-CH-IUniRule annotation
    Gene namesi
    Name:folEUniRule annotation
    Ordered Locus Names:CLJ_B1666
    OrganismiClostridium botulinum (strain 657 / Type Ba4)
    Taxonomic identifieri515621 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000002333: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 196196GTP cyclohydrolase 1PRO_1000204285Add
    BLAST

    Interactioni

    Subunit structurei

    Homopolymer.UniRule annotation

    Protein-protein interaction databases

    STRINGi515621.CLJ_B1666.

    Structurei

    3D structure databases

    ProteinModelPortaliC3KVW3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase I family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0302.
    HOGENOMiHOG000221222.
    KOiK01495.
    OMAiMNMRGVK.
    OrthoDBiEOG6XHC8G.

    Family and domain databases

    HAMAPiMF_00223. FolE.
    InterProiIPR001474. GTP_CycHdrlase_I.
    IPR018234. GTP_CycHdrlase_I_CS.
    IPR020602. GTP_CycHdrlase_I_dom.
    [Graphical view]
    PANTHERiPTHR11109. PTHR11109. 1 hit.
    PfamiPF01227. GTP_cyclohydroI. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00063. folE. 1 hit.
    PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C3KVW3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIDVKAIEE HIKGILIALG DNPEREGLKD TPKRVAKMYE EVFKGMCYTN    50
    DEIAEMFNVT FEEDLCVSDN VGDMVFMKDI EIFSHCEHHL ALMYNMKVAI 100
    AYIPKGKIIG LSKIARIADM VGRRLQLQER IGSDIAEILK MITDSEDVAV 150
    IIEGEHGCMT TRGIKKTGAK TITTTLRGKF NTDTIVSNKL MMLYTK 196
    Length:196
    Mass (Da):22,039
    Last modified:June 16, 2009 - v1
    Checksum:i1F504EDE0BA2DED6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001083 Genomic DNA. Translation: ACQ51929.1.
    RefSeqiYP_002862451.1. NC_012658.1.

    Genome annotation databases

    EnsemblBacteriaiACQ51929; ACQ51929; CLJ_B1666.
    GeneIDi7880058.
    KEGGicbi:CLJ_B1666.
    PATRICi19411720. VBICloBot19908_1890.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001083 Genomic DNA. Translation: ACQ51929.1 .
    RefSeqi YP_002862451.1. NC_012658.1.

    3D structure databases

    ProteinModelPortali C3KVW3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 515621.CLJ_B1666.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACQ51929 ; ACQ51929 ; CLJ_B1666 .
    GeneIDi 7880058.
    KEGGi cbi:CLJ_B1666.
    PATRICi 19411720. VBICloBot19908_1890.

    Phylogenomic databases

    eggNOGi COG0302.
    HOGENOMi HOG000221222.
    KOi K01495.
    OMAi MNMRGVK.
    OrthoDBi EOG6XHC8G.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci CBOT515621:GCP3-1641-MONOMER.

    Family and domain databases

    HAMAPi MF_00223. FolE.
    InterProi IPR001474. GTP_CycHdrlase_I.
    IPR018234. GTP_CycHdrlase_I_CS.
    IPR020602. GTP_CycHdrlase_I_dom.
    [Graphical view ]
    PANTHERi PTHR11109. PTHR11109. 1 hit.
    Pfami PF01227. GTP_cyclohydroI. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00063. folE. 1 hit.
    PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Clostridium botulinum Ba4 strain 657."
      Shrivastava S., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
      Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 657 / Type Ba4.

    Entry informationi

    Entry nameiGCH1_CLOB6
    AccessioniPrimary (citable) accession number: C3KVW3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3