C3KVW3 (GCH1_CLOB6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase 1
EC=3.5.4.16

Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I

Gene names

Name:	folE
Ordered Locus Names:	CLJ_B1666

Organism

Clostridium botulinum (strain 657 / Type Ba4) [Complete proteome] [HAMAP]

Taxonomic identifier

515621 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium › Clostridium botulinum › Clostridium botulinum B

Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223
Subunit structure	Homopolymer By similarity.
Sequence similarities	Belongs to the GTP cyclohydrolase I family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	GTP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	7,8-dihydroneopterin 3'-triphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 196	196	GTP cyclohydrolase 1 HAMAP-Rule MF_00223		PRO_1000204285
Sites
	Metal binding	86	1	Zinc By similarity
	Metal binding	89	1	Zinc By similarity
	Metal binding	158	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	C3KVW3 [UniParc]. Last modified June 16, 2009. Version 1. Checksum: 1F504EDE0BA2DED6	FASTA	196	22,039
	10 20 30 40 50 60 MAIDVKAIEE HIKGILIALG DNPEREGLKD TPKRVAKMYE EVFKGMCYTN DEIAEMFNVT 70 80 90 100 110 120 FEEDLCVSDN VGDMVFMKDI EIFSHCEHHL ALMYNMKVAI AYIPKGKIIG LSKIARIADM 130 140 150 160 170 180 VGRRLQLQER IGSDIAEILK MITDSEDVAV IIEGEHGCMT TRGIKKTGAK TITTTLRGKF 190 NTDTIVSNKL MMLYTK

References

[1]

"Genome sequence of Clostridium botulinum Ba4 strain 657." Shrivastava S., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S. Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 657 / Type Ba4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001083 Genomic DNA. Translation: ACQ51929.1.
RefSeq	YP_002862451.1. NC_012658.1.
3D structure databases
ProteinModelPortal	C3KVW3.
ModBase	Search...
Protein-protein interaction databases
STRING	515621.CLJ_B1666.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACQ51929; ACQ51929; CLJ_B1666.
GeneID	7880058.
KEGG	cbi:CLJ_B1666.
PATRIC	19411720. VBICloBot19908_1890.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0302.
HOGENOM	HOG000221222.
KO	K01495.
OMA	ARYARWW.
ProtClustDB	PRK09347.
Enzyme and pathway databases
UniPathway	UPA00848; UER00151.
Family and domain databases
HAMAP	MF_00223. FolE.
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
PANTHER	PTHR11109. PTHR11109. 1 hit.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
TIGRFAMs	TIGR00063. folE. 1 hit.
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. PS00860. GTP_CYCLOHYDROL_1_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH1_CLOB6

Accession

Primary (citable) accession number: C3KVW3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	June 16, 2009
Last modified:	May 1, 2013
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program