Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

C3KVW3 (GCH1_CLOB6) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:CLJ_B1666
OrganismClostridium botulinum (strain 657 / Type Ba4) [Complete proteome] [HAMAP]
Taxonomic identifier515621 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length196 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Homopolymer By similarity. HAMAP-Rule MF_00223

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 196196GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_1000204285

Sites

Metal binding861Zinc By similarity
Metal binding891Zinc By similarity
Metal binding1581Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
C3KVW3 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: 1F504EDE0BA2DED6

FASTA19622,039
        10         20         30         40         50         60 
MAIDVKAIEE HIKGILIALG DNPEREGLKD TPKRVAKMYE EVFKGMCYTN DEIAEMFNVT 

        70         80         90        100        110        120 
FEEDLCVSDN VGDMVFMKDI EIFSHCEHHL ALMYNMKVAI AYIPKGKIIG LSKIARIADM 

       130        140        150        160        170        180 
VGRRLQLQER IGSDIAEILK MITDSEDVAV IIEGEHGCMT TRGIKKTGAK TITTTLRGKF 

       190 
NTDTIVSNKL MMLYTK 

« Hide

References

[1]"Genome sequence of Clostridium botulinum Ba4 strain 657."
Shrivastava S., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 657 / Type Ba4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001083 Genomic DNA. Translation: ACQ51929.1.
RefSeqYP_002862451.1. NC_012658.1.

3D structure databases

ProteinModelPortalC3KVW3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING515621.CLJ_B1666.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACQ51929; ACQ51929; CLJ_B1666.
GeneID7880058.
KEGGcbi:CLJ_B1666.
PATRIC19411720. VBICloBot19908_1890.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0302.
HOGENOMHOG000221222.
KOK01495.
OMAMNMRGVK.
OrthoDBEOG6XHC8G.

Enzyme and pathway databases

BioCycCBOT515621:GCP3-1641-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_CLOB6
AccessionPrimary (citable) accession number: C3KVW3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: May 14, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways