true2009-09-222024-01-2475PFKA_CLOB6Genome sequence of Clostridium botulinum Ba4 strain 657.Shrivastava S.Brown J.L.Bruce D.Detter C.Munk C.Smith L.A.Smith T.J.Sutton G.Brettin T.S.2008-05EMBL/GenBank/DDBJNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]657 / Type Ba4Phosphofructokinase domainPhosphofructokinase_I_B1ATP_PFKATP_PFK_prok-typePFKA_ATP_prokPhosphofructokinase_CSPhosphofructokinase_domPKF_sfPFKA_ATPATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE, MUSCLE TYPEPHOSPHOFRUCTOKINASEPFKATP_PFK_prokPHFRCTKINASEPhosphofructokinasePHOSPHOFRUCTOKINASEATP-dependent 6-phosphofructokinaseATP-PFKPhosphofructokinase2.7.1.11PhosphohexokinasepfkACLJ_B3676Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.Homotetramer.Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.ATP-dependent 6-phosphofructokinase342041319Proton acceptor1271121257273102105103in other chain125in other chain154162in other chain169171in other chain185187in other chain211in other chain213215in other chain222243in other chain249252allosteric activator; ligand shared between dimeric partnerscatalyticsubstrateligand shared between dimeric partners2009-06-16134204b90bfa13fcec71beb09665805297a301MRTIAVLTSGGDAPGMNAAIRAVVRTGLEKGLKVMGIQRGYNGLINGEIFEMDTHSVSDIIQRGGTILRTARCEEFRTEQGREKAAKILKAFGIDGLVVIGGDGSFHGAQLLSKLGINTVGLPGTIDNDLAYTDYTIGFDTSINTVLDAINKLRDTSTSHERVSVVEVMGRNCGDIALYTGVAGGAESIIIPEKEYNADKLCKQILQGKLKGKMHNLVLLAEGVGGANELAKYIEEVTGIETRSTILGHIQRGGSPTCMDRILASRMAYKAVELLISGKSSRVVGIKNGEIIDMDIDEALAVERSFDQELYDIATILSKtrue