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C3KUC8 (CH60_CLOB6) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
60 kDa chaperonin
Alternative name(s):
GroEL protein
Protein Cpn60
Gene names
Name:groL
Synonyms:groEL
Ordered Locus Names:CLJ_B3579
OrganismClostridium botulinum (strain 657 / Type Ba4) [Complete proteome] [HAMAP]
Taxonomic identifier515621 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium ›

Protein attributes

Sequence length541 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions By similarity. HAMAP-Rule MF_00600

Subunit structure

Oligomer of 14 subunits composed of two stacked rings of 7 subunits By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00600.

Sequence similarities

Belongs to the chaperonin (HSP60) family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionChaperone
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotein refolding

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 54154160 kDa chaperonin HAMAP-Rule MF_00600
PRO_1000212192

Sequences

Sequence LengthMass (Da)Tools
C3KUC8 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: 5A130C3A7664E20F

FASTA54157,936
        10         20         30         40         50         60 
MAKSLLFGEQ ARRSMEAGVD KLADTVRVTL GPKGRNVVLD KKFGSPLITN DGVTIAREIE 

        70         80         90        100        110        120 
LEDPYENMGA QLVKEVATKT NDVAGDGTTT ATLLAQAIIR EGLKNVTAGA NPIQIRTGIR 

       130        140        150        160        170        180 
KAVEKAVEEI KVISKPVNGK EDIARVAAIS AASEEVGKLI ADAMERVGND GVITVEESKS 

       190        200        210        220        230        240 
MGTDLEVVEG MQFDRGYVSA YMVTDTEKME AVLDDVYILI TDKKISNIQE ILPILEQIVQ 

       250        260        270        280        290        300 
QGKKLLIISE DIEGEALSTL VLNKLRGTFT CVGVKAPGFG DRRKEMLQDI AILTGGEVIS 

       310        320        330        340        350        360 
EELGRDLKDV TIDMLGTADS VKVTKENTTI VNGKGDKVAI KERVSQIRVQ IEDTTSEFDK 

       370        380        390        400        410        420 
EKLQERLAKL AGGVAVIRVG AATETELKEE KLRIEDALAA TKAAVEEGIV PGGGTAYIDI 

       430        440        450        460        470        480 
IPKIADLTSD IIDVKLGIDI IRKALEEPVR QIANNAGVEG SVIIEKVKAS EAGVGYDALN 

       490        500        510        520        530        540 
DKYVDMLKTG IVDPTKVTRS ALQNAASIAS TFLTTEAAVA DIPEKENTPP MAPGMGMDGM 


Y

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References

[1]"Genome sequence of Clostridium botulinum Ba4 strain 657."
Shrivastava S., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A., Smith T.J., Sutton G., Brettin T.S.
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 657 / Type Ba4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001083 Genomic DNA. Translation: ACQ52812.1.
RefSeqYP_002864290.1. NC_012658.1.

3D structure databases

ProteinModelPortalC3KUC8.
SMRC3KUC8. Positions 2-525.
ModBaseSearch...

Protein-protein interaction databases

STRING515621.CLJ_B3579.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACQ52812; ACQ52812; CLJ_B3579.
GeneID7878199.
KEGGcbi:CLJ_B3579.
PATRIC19415469. VBICloBot19908_3734.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0459.
HOGENOMHOG000076290.
KOK04077.
OMACATRAAV.
ProtClustDBPRK00013.

Enzyme and pathway databases

BioCycCBOT515621:GCP3-3536-MONOMER.

Family and domain databases

Gene3D1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPMF_00600. CH60.
InterProIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PANTHERPTHR11353. PTHR11353. 1 hit.
PfamPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSPR00298. CHAPERONIN60.
SUPFAMSSF48592. GroEL-ATPase. 1 hit.
SSF52029. SSF52029. 1 hit.
TIGRFAMsTIGR02348. GroEL. 1 hit.
PROSITEPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCH60_CLOB6
AccessionPrimary (citable) accession number: C3KUC8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: May 29, 2013
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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