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C3KBW8 (C3KBW8_PSEFS) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddlA EMBL CAY46974.1
Synonyms:ddl HAMAP-Rule MF_00047
Ordered Locus Names:PFLU_0706 EMBL CAY46974.1
OrganismPseudomonas fluorescens (strain SBW25) [Complete proteome] [HAMAP] EMBL CAY46974.1
Taxonomic identifier216595 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain145 – 348204ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding175 – 23056ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3021Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3151Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3151Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3171Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
C3KBW8 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: 023A0052CED7A865

FASTA36439,056
        10         20         30         40         50         60 
MSKVRVGIIF GGRSAEHEVS LQSARNIVDA LDRTRFEPVL IGIDKAGHWH LNDTSNFLLN 

        70         80         90        100        110        120 
QENPALIALN QSNRELAVVP GKASQQLVET SGTGLLEHVD VIFPIVHGTL GEDGCLQGLL 

       130        140        150        160        170        180 
RMADLPFVGS DVLGSAVCMD KDISKRLLRD AGIAVTPFIT LTRSNATRTS FDTAVNTLGL 

       190        200        210        220        230        240 
PMFVKPANQG SSVGVSKVGT EAEYHAAVEL ALGFDEKVLV ESAVKGREIE CAVLGNEHPI 

       250        260        270        280        290        300 
ASGCGEIVVS SGFYSYDSKY IDDQAAQVVV PAAISHDASE RIRGLAIEAF EVLGCSGLAR 

       310        320        330        340        350        360 
VDVFLTDDGN VLINEINSLP GFTRISMYPK LWQAAGMSYS ELVSRLIELA LERHAGRKGL 


KISR 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM181176 Genomic DNA. Translation: CAY46974.1.
RefSeqYP_002870373.1. NC_012660.1.

3D structure databases

ProteinModelPortalC3KBW8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING216595.PFLU0706.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAY46974; CAY46974; PFLU_0706.
GeneID7817998.
KEGGpfs:PFLU0706.
PATRIC19895640. VBIPseFlu98510_0944.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
KOK01921.
OMAMDKIAMK.
OrthoDBEOG64BQ73.
ProtClustDBPRK01966.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC3KBW8_PSEFS
AccessionPrimary (citable) accession number: C3KBW8
Entry history
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: April 16, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)