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C3K9T0

- NADK_PSEFS

UniProt

C3K9T0 - NADK_PSEFS

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Protein

NAD kinase

Gene

nadK

Organism
Pseudomonas fluorescens (strain SBW25)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei72 – 721Proton acceptorUniRule annotation
Binding sitei157 – 1571NADUniRule annotation
Binding sitei174 – 1741NADUniRule annotation
Binding sitei176 – 1761NADUniRule annotation
Binding sitei247 – 2471NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi72 – 732NADUniRule annotation
Nucleotide bindingi146 – 1472NADUniRule annotation
Nucleotide bindingi187 – 1926NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:PFLU_2674
OrganismiPseudomonas fluorescens (strain SBW25)
Taxonomic identifieri216595 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002332: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296NAD kinasePRO_1000205421Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216595.PFLU2674.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
KOiK00858.
OMAiTHEMLYH.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

C3K9T0 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEHFRNIGII GRLGSTQVLD TVRRLKKFLL ERHLHVILED TIAEILPGHG
60 70 80 90 100
LQTSSRKMLG EVCDMVIVVG GDGSLLGAAR ALARHNVPVL GINRGSLGFL
110 120 130 140 150
TDIRPDELEV EVAKVLDGHY LVENRFLLQA EVRRHGEAIG QGDALNDVVL
160 170 180 190 200
HPGKSTRMIE FELYIDGQFV CSQKADGLIV ATPTGSTAYA LSAGGPIMHP
210 220 230 240 250
KLDAIVIVPM YPHMLSSRPI VVDGNSELKI VVSKDMQIYP QVSCDGQNHF
260 270 280 290
TCAPGDTITV SKKAQKLRLI HPLDHNYYEV CRTKLGWGSR LGGGGD
Length:296
Mass (Da):32,309
Last modified:June 16, 2009 - v1
Checksum:i47A12D2D68C04080
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM181176 Genomic DNA. Translation: CAY48906.1.
RefSeqiYP_002872258.1. NC_012660.1.

Genome annotation databases

EnsemblBacteriaiCAY48906; CAY48906; PFLU_2674.
GeneIDi7821840.
KEGGipfs:PFLU2674.
PATRICi19899552. VBIPseFlu98510_2879.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM181176 Genomic DNA. Translation: CAY48906.1 .
RefSeqi YP_002872258.1. NC_012660.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216595.PFLU2674.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAY48906 ; CAY48906 ; PFLU_2674 .
GeneIDi 7821840.
KEGGi pfs:PFLU2674.
PATRICi 19899552. VBIPseFlu98510_2879.

Phylogenomic databases

eggNOGi COG0061.
KOi K00858.
OMAi THEMLYH.
OrthoDBi EOG6PZXDR.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SBW25.

Entry informationi

Entry nameiNADK_PSEFS
AccessioniPrimary (citable) accession number: C3K9T0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: October 29, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3