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Protein

NAD kinase

Gene

nadK

Organism
Pseudomonas fluorescens (strain SBW25)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei72Proton acceptorUniRule annotation1
Binding sitei157NADUniRule annotation1
Binding sitei174NADUniRule annotation1
Binding sitei176NADUniRule annotation1
Binding sitei247NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi72 – 73NADUniRule annotation2
Nucleotide bindingi146 – 147NADUniRule annotation2
Nucleotide bindingi187 – 192NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:PFLU_2674
OrganismiPseudomonas fluorescens (strain SBW25)
Taxonomic identifieri216595 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002332 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002054211 – 296NAD kinaseAdd BLAST296

Proteomic databases

PRIDEiC3K9T0.

Interactioni

Protein-protein interaction databases

STRINGi216595.PFLU2674.

Structurei

3D structure databases

SMRiC3K9T0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91. Bacteria.
COG0061. LUCA.
KOiK00858.
OMAiVNLGHVG.
OrthoDBiPOG091H02D1.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiView protein in InterPro
IPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiView protein in Pfam
PF01513. NAD_kinase. 1 hit.
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

C3K9T0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHFRNIGII GRLGSTQVLD TVRRLKKFLL ERHLHVILED TIAEILPGHG
60 70 80 90 100
LQTSSRKMLG EVCDMVIVVG GDGSLLGAAR ALARHNVPVL GINRGSLGFL
110 120 130 140 150
TDIRPDELEV EVAKVLDGHY LVENRFLLQA EVRRHGEAIG QGDALNDVVL
160 170 180 190 200
HPGKSTRMIE FELYIDGQFV CSQKADGLIV ATPTGSTAYA LSAGGPIMHP
210 220 230 240 250
KLDAIVIVPM YPHMLSSRPI VVDGNSELKI VVSKDMQIYP QVSCDGQNHF
260 270 280 290
TCAPGDTITV SKKAQKLRLI HPLDHNYYEV CRTKLGWGSR LGGGGD
Length:296
Mass (Da):32,309
Last modified:June 16, 2009 - v1
Checksum:i47A12D2D68C04080
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM181176 Genomic DNA. Translation: CAY48906.1.
RefSeqiWP_003190745.1. NC_012660.1.

Genome annotation databases

EnsemblBacteriaiCAY48906; CAY48906; PFLU_2674.
KEGGipfs:PFLU_2674.

Similar proteinsi

Entry informationi

Entry nameiNADK_PSEFS
AccessioniPrimary (citable) accession number: C3K9T0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: September 27, 2017
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families