C3K9I8 (IOLG_PSEFS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase
Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	PFLU_2580

Organism

Pseudomonas fluorescens (strain SBW25) [Complete proteome] [HAMAP]

Taxonomic identifier

216595 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 336	336	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_1000215885

Sequences

	Sequence		Length	Mass (Da)
	C3K9I8 [UniParc]. Last modified June 16, 2009. Version 1. Checksum: 173842A2072D598D	FASTA	336	36,605
	10 20 30 40 50 60 MSLKLGVIGT GAIGRDHIRR CSQTLLNSQV VAVTDINLEQ AAKVVADLKL DAEVYPDGHA 70 80 90 100 110 120 LINSPQVEAV LVTSWGPSHE EFVLAAIAAG KPVFCEKPLA VTAEGCRRIV DAEVAYGKRL 130 140 150 160 170 180 VQVGFMRPYD EGYRALKAVI DSGQIGEPLM LHCAHRNPTV GENYKTDMAI TDTLIHELDV 190 200 210 220 230 240 LRWLLNDDYV SVQVVFPRKS SKALAHLRDP QIVLLETAKG TRIDVEVFVN CQYGYDIQCE 250 260 270 280 290 300 VVGETGIAKL PEPSQVQLRS GAKLSNAILM DWKDRFIGAY DVELQAFIDS VRAGQVGGPS 310 320 330 AWDGFAAAVA ADACIEAQGS EQIVKMSLPD RPRFYG

References

[1]

"Genomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens." Silby M.W., Cerdeno-Tarraga A.M., Vernikos G.S., Giddens S.R., Jackson R.W., Preston G.M., Zhang X.-X., Moon C.D., Gehrig S.M., Godfrey S.A.C., Knight C.G., Malone J.G., Robinson Z., Spiers A.J., Harris S., Challis G.L., Yaxley A.M., Harris D. , Seeger K., Murphy L., Rutter S., Squares R., Quail M.A., Saunders E., Mavromatis K., Brettin T.S., Bentley S.D., Hothersall J., Stephens E., Thomas C.M., Parkhill J., Levy S.B., Rainey P.B., Thomson N.R. Genome Biol. 10:R51.1-R51.16(2009) [PubMed: 19432983] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SBW25.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM181176 Genomic DNA. Translation: CAY48814.1.
RefSeq	YP_002872167.1. NC_012660.1.
3D structure databases
ProteinModelPortal	C3K9I8.
ModBase	Search...
Protein-protein interaction databases
STRING	C3K9I8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7820593.
GenomeReviews	Gene locus PFLU_2580 in contig AM181176_GR.
KEGG	pfs:PFLU2580.
PATRIC	19899362. VBIPseFlu98510_2784.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	YDVELQD.
ProtClustDB	CLSK2757149.
Enzyme and pathway databases
BioCyc	PFLU216595:PFLU2580-MONOMER.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_PSEFS

Accession

Primary (citable) accession number: C3K9I8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	June 16, 2009
Last modified:	January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program