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C3K6G9

- LPXB_PSEFS

UniProt

C3K6G9 - LPXB_PSEFS

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Protein

Lipid-A-disaccharide synthase

Gene
lpxB, PFLU_1283
Organism
Pseudomonas fluorescens (strain SBW25)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:PFLU_1283
OrganismiPseudomonas fluorescens (strain SBW25)
Taxonomic identifieri216595 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002332: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379Lipid-A-disaccharide synthaseUniRule annotationPRO_1000205846Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216595.PFLU1283.

Structurei

3D structure databases

ProteinModelPortaliC3K6G9.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

C3K6G9-1 [UniParc]FASTAAdd to Basket

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MANLRIALVA GEASGDILGA GLMRALKAQH PAVQFIGVGG PLMQAEGLTS    50
YFPMERLSVM GLVEVLGRLR ELLARRKLLI QTLIEEKPDV FIGIDAPDFT 100
LTLELKLRQA GIKTVHYVSP SVWAWRQKRV LKIREGCDLM LTLLPFEARF 150
YEEKGVPVRF VGHTLADTIP LQADRTAARA ELGLPDGPLV ALMPGSRGGE 200
VGRLASVFFD AAERLQALKP GVRFVLPCAS PQRRVQIETL LEGRNLPLTL 250
LDGQSHLALA ACDAVLIASG TATLEALLYK RPMVVAYRLA PLTFWILKRM 300
VKSPYISLPN LLAQRLLVPE LLQDDATPEA LAQTLLPLID GGEEQTRGFD 350
DIHRTLRRDA SNQAADAVLS LIGQKQEAL 379
Length:379
Mass (Da):41,494
Last modified:June 16, 2009 - v1
Checksum:i0C5721373C13465A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM181176 Genomic DNA. Translation: CAY47540.1.
RefSeqiWP_012722604.1. NC_012660.1.
YP_002870935.1. NC_012660.1.

Genome annotation databases

EnsemblBacteriaiCAY47540; CAY47540; PFLU_1283.
GeneIDi7816530.
KEGGipfs:PFLU1283.
PATRICi19896792. VBIPseFlu98510_1514.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM181176 Genomic DNA. Translation: CAY47540.1 .
RefSeqi WP_012722604.1. NC_012660.1.
YP_002870935.1. NC_012660.1.

3D structure databases

ProteinModelPortali C3K6G9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216595.PFLU1283.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAY47540 ; CAY47540 ; PFLU_1283 .
GeneIDi 7816530.
KEGGi pfs:PFLU1283.
PATRICi 19896792. VBIPseFlu98510_1514.

Phylogenomic databases

eggNOGi COG0763.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SBW25.

Entry informationi

Entry nameiLPXB_PSEFS
AccessioniPrimary (citable) accession number: C3K6G9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: September 3, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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