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C3K6G9

- LPXB_PSEFS

UniProt

C3K6G9 - LPXB_PSEFS

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Pseudomonas fluorescens (strain SBW25)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:PFLU_1283
OrganismiPseudomonas fluorescens (strain SBW25)
Taxonomic identifieri216595 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002332: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379Lipid-A-disaccharide synthasePRO_1000205846Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216595.PFLU1283.

Structurei

3D structure databases

ProteinModelPortaliC3K6G9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

C3K6G9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANLRIALVA GEASGDILGA GLMRALKAQH PAVQFIGVGG PLMQAEGLTS
60 70 80 90 100
YFPMERLSVM GLVEVLGRLR ELLARRKLLI QTLIEEKPDV FIGIDAPDFT
110 120 130 140 150
LTLELKLRQA GIKTVHYVSP SVWAWRQKRV LKIREGCDLM LTLLPFEARF
160 170 180 190 200
YEEKGVPVRF VGHTLADTIP LQADRTAARA ELGLPDGPLV ALMPGSRGGE
210 220 230 240 250
VGRLASVFFD AAERLQALKP GVRFVLPCAS PQRRVQIETL LEGRNLPLTL
260 270 280 290 300
LDGQSHLALA ACDAVLIASG TATLEALLYK RPMVVAYRLA PLTFWILKRM
310 320 330 340 350
VKSPYISLPN LLAQRLLVPE LLQDDATPEA LAQTLLPLID GGEEQTRGFD
360 370
DIHRTLRRDA SNQAADAVLS LIGQKQEAL
Length:379
Mass (Da):41,494
Last modified:June 16, 2009 - v1
Checksum:i0C5721373C13465A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM181176 Genomic DNA. Translation: CAY47540.1.
RefSeqiYP_002870935.1. NC_012660.1.

Genome annotation databases

EnsemblBacteriaiCAY47540; CAY47540; PFLU_1283.
GeneIDi7816530.
KEGGipfs:PFLU1283.
PATRICi19896792. VBIPseFlu98510_1514.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM181176 Genomic DNA. Translation: CAY47540.1 .
RefSeqi YP_002870935.1. NC_012660.1.

3D structure databases

ProteinModelPortali C3K6G9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216595.PFLU1283.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAY47540 ; CAY47540 ; PFLU_1283 .
GeneIDi 7816530.
KEGGi pfs:PFLU1283.
PATRICi 19896792. VBIPseFlu98510_1514.

Phylogenomic databases

eggNOGi COG0763.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SBW25.

Entry informationi

Entry nameiLPXB_PSEFS
AccessioniPrimary (citable) accession number: C3K6G9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: October 29, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3