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C3K4H5

- GCH4_PSEFS

UniProt

C3K4H5 - GCH4_PSEFS

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Pseudomonas fluorescens (strain SBW25)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei149 – 1491May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:PFLU_6088
    OrganismiPseudomonas fluorescens (strain SBW25)
    Taxonomic identifieri216595 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002332: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 298298GTP cyclohydrolase FolE2PRO_1000215393Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi216595.PFLU6088.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    KOiK09007.
    OMAiAGRTTIQ.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C3K4H5-1 [UniParc]FASTAAdd to Basket

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    MNALTLPDIA AQASRQALPL DWVGMCGIAL PILIDGQRLT ATADAGVSLD    50
    DGAARGIHMS RLYLALEMLD QQPLTPALLR NVLQRFLDSH EGLSNNAYLR 100
    IHTDLLLKRP ALVSPLAGWK RYPVSIEARL ENQMFHVELK IDVTYSSTCP 150
    CSAALARQLI QQQFLDDFGD TSLRHEDVLT WLGSANGIVA TPHSQRSSAQ 200
    LLITLDGDQA GLPINDLIDN VEAALGTAVQ TAVKRADEQA FALANGQNLM 250
    FCEDAARRLN LALKRSDAVK AFHLKVIHAE SLHAHDAVAE SRWTRNPA 298
    Length:298
    Mass (Da):32,534
    Last modified:June 16, 2009 - v1
    Checksum:iE717B5032B158929
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM181176 Genomic DNA. Translation: CAY53675.1.
    RefSeqiYP_002875570.1. NC_012660.1.

    Genome annotation databases

    EnsemblBacteriaiCAY53675; CAY53675; PFLU_6088.
    GeneIDi7818322.
    KEGGipfs:PFLU6088.
    PATRICi19906300. VBIPseFlu98510_6212.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM181176 Genomic DNA. Translation: CAY53675.1 .
    RefSeqi YP_002875570.1. NC_012660.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 216595.PFLU6088.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAY53675 ; CAY53675 ; PFLU_6088 .
    GeneIDi 7818322.
    KEGGi pfs:PFLU6088.
    PATRICi 19906300. VBIPseFlu98510_6212.

    Phylogenomic databases

    eggNOGi COG1469.
    KOi K09007.
    OMAi AGRTTIQ.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SBW25.

    Entry informationi

    Entry nameiGCH4_PSEFS
    AccessioniPrimary (citable) accession number: C3K4H5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3