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C3K4H5 (GCH4_PSEFS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GTP cyclohydrolase folE2
EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:PFLU_6088
OrganismPseudomonas fluorescens (strain SBW25) [Complete proteome] [HAMAP]
Taxonomic identifier216595 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas ›

Protein attributes

Sequence length298 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 298298GTP cyclohydrolase folE2 HAMAP-Rule MF_01527
PRO_1000215393

Sites

Site1491May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
C3K4H5 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: E717B5032B158929

FASTA29832,534
        10         20         30         40         50         60 
MNALTLPDIA AQASRQALPL DWVGMCGIAL PILIDGQRLT ATADAGVSLD DGAARGIHMS 

        70         80         90        100        110        120 
RLYLALEMLD QQPLTPALLR NVLQRFLDSH EGLSNNAYLR IHTDLLLKRP ALVSPLAGWK 

       130        140        150        160        170        180 
RYPVSIEARL ENQMFHVELK IDVTYSSTCP CSAALARQLI QQQFLDDFGD TSLRHEDVLT 

       190        200        210        220        230        240 
WLGSANGIVA TPHSQRSSAQ LLITLDGDQA GLPINDLIDN VEAALGTAVQ TAVKRADEQA 

       250        260        270        280        290 
FALANGQNLM FCEDAARRLN LALKRSDAVK AFHLKVIHAE SLHAHDAVAE SRWTRNPA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM181176 Genomic DNA. Translation: CAY53675.1.
RefSeqYP_002875570.1. NC_012660.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING216595.PFLU6088.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAY53675; CAY53675; PFLU_6088.
GeneID7818322.
KEGGpfs:PFLU6088.
PATRIC19906300. VBIPseFlu98510_6212.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
KOK09007.
OMALNGQNLM.
ProtClustDBPRK13674.

Enzyme and pathway databases

UniPathwayUPA00848; UER00151.

Family and domain databases

Gene3D3.10.270.10. 2 hits.
HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
IPR002042. Uricase.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_PSEFS
AccessionPrimary (citable) accession number: C3K4H5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: May 1, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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