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C3K4H5

- GCH4_PSEFS

UniProt

C3K4H5 - GCH4_PSEFS

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Pseudomonas fluorescens (strain SBW25)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei149 – 1491May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:PFLU_6088
OrganismiPseudomonas fluorescens (strain SBW25)
Taxonomic identifieri216595 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002332: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298GTP cyclohydrolase FolE2PRO_1000215393Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216595.PFLU6088.

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
KOiK09007.
OMAiAGRTTIQ.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3K4H5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNALTLPDIA AQASRQALPL DWVGMCGIAL PILIDGQRLT ATADAGVSLD
60 70 80 90 100
DGAARGIHMS RLYLALEMLD QQPLTPALLR NVLQRFLDSH EGLSNNAYLR
110 120 130 140 150
IHTDLLLKRP ALVSPLAGWK RYPVSIEARL ENQMFHVELK IDVTYSSTCP
160 170 180 190 200
CSAALARQLI QQQFLDDFGD TSLRHEDVLT WLGSANGIVA TPHSQRSSAQ
210 220 230 240 250
LLITLDGDQA GLPINDLIDN VEAALGTAVQ TAVKRADEQA FALANGQNLM
260 270 280 290
FCEDAARRLN LALKRSDAVK AFHLKVIHAE SLHAHDAVAE SRWTRNPA
Length:298
Mass (Da):32,534
Last modified:June 16, 2009 - v1
Checksum:iE717B5032B158929
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM181176 Genomic DNA. Translation: CAY53675.1.
RefSeqiYP_002875570.1. NC_012660.1.

Genome annotation databases

EnsemblBacteriaiCAY53675; CAY53675; PFLU_6088.
GeneIDi7818322.
KEGGipfs:PFLU6088.
PATRICi19906300. VBIPseFlu98510_6212.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM181176 Genomic DNA. Translation: CAY53675.1 .
RefSeqi YP_002875570.1. NC_012660.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216595.PFLU6088.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAY53675 ; CAY53675 ; PFLU_6088 .
GeneIDi 7818322.
KEGGi pfs:PFLU6088.
PATRICi 19906300. VBIPseFlu98510_6212.

Phylogenomic databases

eggNOGi COG1469.
KOi K09007.
OMAi AGRTTIQ.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SBW25.

Entry informationi

Entry nameiGCH4_PSEFS
AccessioniPrimary (citable) accession number: C3K4H5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: October 1, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3