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C3K4H5

- GCH4_PSEFS

UniProt

C3K4H5 - GCH4_PSEFS

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Protein
GTP cyclohydrolase FolE2
Gene
folE2, PFLU_6088
Organism
Pseudomonas fluorescens (strain SBW25)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei149 – 1491May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:PFLU_6088
OrganismiPseudomonas fluorescens (strain SBW25)
Taxonomic identifieri216595 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002332: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298GTP cyclohydrolase FolE2UniRule annotation
PRO_1000215393Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216595.PFLU6088.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
KOiK09007.
OMAiAGRTTIQ.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3K4H5-1 [UniParc]FASTAAdd to Basket

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MNALTLPDIA AQASRQALPL DWVGMCGIAL PILIDGQRLT ATADAGVSLD    50
DGAARGIHMS RLYLALEMLD QQPLTPALLR NVLQRFLDSH EGLSNNAYLR 100
IHTDLLLKRP ALVSPLAGWK RYPVSIEARL ENQMFHVELK IDVTYSSTCP 150
CSAALARQLI QQQFLDDFGD TSLRHEDVLT WLGSANGIVA TPHSQRSSAQ 200
LLITLDGDQA GLPINDLIDN VEAALGTAVQ TAVKRADEQA FALANGQNLM 250
FCEDAARRLN LALKRSDAVK AFHLKVIHAE SLHAHDAVAE SRWTRNPA 298
Length:298
Mass (Da):32,534
Last modified:June 16, 2009 - v1
Checksum:iE717B5032B158929
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM181176 Genomic DNA. Translation: CAY53675.1.
RefSeqiYP_002875570.1. NC_012660.1.

Genome annotation databases

EnsemblBacteriaiCAY53675; CAY53675; PFLU_6088.
GeneIDi7818322.
KEGGipfs:PFLU6088.
PATRICi19906300. VBIPseFlu98510_6212.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM181176 Genomic DNA. Translation: CAY53675.1 .
RefSeqi YP_002875570.1. NC_012660.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216595.PFLU6088.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAY53675 ; CAY53675 ; PFLU_6088 .
GeneIDi 7818322.
KEGGi pfs:PFLU6088.
PATRICi 19906300. VBIPseFlu98510_6212.

Phylogenomic databases

eggNOGi COG1469.
KOi K09007.
OMAi AGRTTIQ.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SBW25.

Entry informationi

Entry nameiGCH4_PSEFS
AccessioniPrimary (citable) accession number: C3K4H5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: May 14, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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