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C3K3D3

- BETA_PSEFS

UniProt

C3K3D3 - BETA_PSEFS

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Protein

Oxygen-dependent choline dehydrogenase

Gene
betA, PFLU_5686
Organism
Pseudomonas fluorescens (strain SBW25)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei475 – 4751 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 3530FAD By similarityAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenase (EC:1.1.99.1)
Short name:
CDH
Short name:
CHD
Alternative name(s):
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betA
Ordered Locus Names:PFLU_5686
OrganismiPseudomonas fluorescens (strain SBW25)
Taxonomic identifieri216595 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002332: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 567567Oxygen-dependent choline dehydrogenaseUniRule annotationPRO_1000212848Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216595.PFLU5686.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2303.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3K3D3-1 [UniParc]FASTAAdd to Basket

« Hide

MSQEYDYIIV GAGSAGNTLA TRLTEDEGVT VLLLEAGGPD YRLDFRTQMP    50
AALAFPLQGR RYNWAYETDP EPHMDGRRME CGRGKGLGGS SLINGMCYIR 100
GNAMDYDNWA KLPGLENWTY LDCLPYFRKA ETRDIGPNDY HGGEGPVSVT 150
TPKAGNNPLF HAMVEAGVQA GYPRTDDLNG YQQEGFGPMD RTVTKNGRRA 200
STARGYLDTA KKRSTLTIVT HALTDKVLFE GKRAVGVRYL IGAAEERVEA 250
RARKEVLVCS GAIASPQLLQ RSGVGPAKLL ESLDIPVVHD LPGVGENLQD 300
HLELYLQYAC TQPVSLYPSL LWYNQPAIGA EWLFNGTGIG ASNQFEAGGF 350
IRSRPEFDWP NIQYHFLPVA INYNGSNGVK EHGFQAHMGS MRSPSRGRVQ 400
LKSKNPRDYP SILFNYMATE QDWQEFRDGI RLTREIMQQP ALDPYRGREI 450
SPGIDVQTDE QLDKFIREHA ETAFHPSCSC KMGTDEMAVV DGEGRVHGMQ 500
GLRVVDASIM PIITTGNLNA PTIMIAEKIA DKIRGRQPLP RSTADYYVAG 550
DAPVRGKPLR EVGPTAQ 567
Length:567
Mass (Da):62,682
Last modified:June 16, 2009 - v1
Checksum:i54531BB4BA312EA3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM181176 Genomic DNA. Translation: CAY53023.1.
RefSeqiYP_002875179.1. NC_012660.1.

Genome annotation databases

EnsemblBacteriaiCAY53023; CAY53023; PFLU_5686.
GeneIDi7816695.
KEGGipfs:PFLU5686.
PATRICi19905494. VBIPseFlu98510_5809.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM181176 Genomic DNA. Translation: CAY53023.1 .
RefSeqi YP_002875179.1. NC_012660.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216595.PFLU5686.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAY53023 ; CAY53023 ; PFLU_5686 .
GeneIDi 7816695.
KEGGi pfs:PFLU5686.
PATRICi 19905494. VBIPseFlu98510_5809.

Phylogenomic databases

eggNOGi COG2303.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SBW25.

Entry informationi

Entry nameiBETA_PSEFS
AccessioniPrimary (citable) accession number: C3K3D3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: September 3, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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