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C3K3D3

- BETA_PSEFS

UniProt

C3K3D3 - BETA_PSEFS

Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Pseudomonas fluorescens (strain SBW25)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

    Catalytic activityi

    Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    FAD.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei475 – 4751UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi6 – 3530FADUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
    2. choline dehydrogenase activity Source: UniProtKB-HAMAP
    3. flavin adenine dinucleotide binding Source: InterPro

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NAD

    Enzyme and pathway databases

    UniPathwayiUPA00529; UER00385.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
    Short name:
    CDHUniRule annotation
    Short name:
    CHDUniRule annotation
    Alternative name(s):
    Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betAUniRule annotation
    Ordered Locus Names:PFLU_5686
    OrganismiPseudomonas fluorescens (strain SBW25)
    Taxonomic identifieri216595 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002332: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 567567Oxygen-dependent choline dehydrogenasePRO_1000212848Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi216595.PFLU5686.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GMC oxidoreductase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2303.
    KOiK00108.
    OMAiYLQYACT.
    OrthoDBiEOG67HJQP.

    Family and domain databases

    HAMAPiMF_00750. Choline_dehydrogen.
    InterProiIPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view]
    PfamiPF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsiTIGR01810. betA. 1 hit.
    PROSITEiPS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C3K3D3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQEYDYIIV GAGSAGNTLA TRLTEDEGVT VLLLEAGGPD YRLDFRTQMP    50
    AALAFPLQGR RYNWAYETDP EPHMDGRRME CGRGKGLGGS SLINGMCYIR 100
    GNAMDYDNWA KLPGLENWTY LDCLPYFRKA ETRDIGPNDY HGGEGPVSVT 150
    TPKAGNNPLF HAMVEAGVQA GYPRTDDLNG YQQEGFGPMD RTVTKNGRRA 200
    STARGYLDTA KKRSTLTIVT HALTDKVLFE GKRAVGVRYL IGAAEERVEA 250
    RARKEVLVCS GAIASPQLLQ RSGVGPAKLL ESLDIPVVHD LPGVGENLQD 300
    HLELYLQYAC TQPVSLYPSL LWYNQPAIGA EWLFNGTGIG ASNQFEAGGF 350
    IRSRPEFDWP NIQYHFLPVA INYNGSNGVK EHGFQAHMGS MRSPSRGRVQ 400
    LKSKNPRDYP SILFNYMATE QDWQEFRDGI RLTREIMQQP ALDPYRGREI 450
    SPGIDVQTDE QLDKFIREHA ETAFHPSCSC KMGTDEMAVV DGEGRVHGMQ 500
    GLRVVDASIM PIITTGNLNA PTIMIAEKIA DKIRGRQPLP RSTADYYVAG 550
    DAPVRGKPLR EVGPTAQ 567
    Length:567
    Mass (Da):62,682
    Last modified:June 16, 2009 - v1
    Checksum:i54531BB4BA312EA3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM181176 Genomic DNA. Translation: CAY53023.1.
    RefSeqiYP_002875179.1. NC_012660.1.

    Genome annotation databases

    EnsemblBacteriaiCAY53023; CAY53023; PFLU_5686.
    GeneIDi7816695.
    KEGGipfs:PFLU5686.
    PATRICi19905494. VBIPseFlu98510_5809.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM181176 Genomic DNA. Translation: CAY53023.1 .
    RefSeqi YP_002875179.1. NC_012660.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 216595.PFLU5686.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAY53023 ; CAY53023 ; PFLU_5686 .
    GeneIDi 7816695.
    KEGGi pfs:PFLU5686.
    PATRICi 19905494. VBIPseFlu98510_5809.

    Phylogenomic databases

    eggNOGi COG2303.
    KOi K00108.
    OMAi YLQYACT.
    OrthoDBi EOG67HJQP.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00385 .

    Family and domain databases

    HAMAPi MF_00750. Choline_dehydrogen.
    InterProi IPR011533. BetA.
    IPR012132. GMC_OxRdtase.
    IPR000172. GMC_OxRdtase_N.
    IPR007867. GMC_OxRtase_C.
    [Graphical view ]
    Pfami PF05199. GMC_oxred_C. 1 hit.
    PF00732. GMC_oxred_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
    TIGRFAMsi TIGR01810. betA. 1 hit.
    PROSITEi PS00623. GMC_OXRED_1. 1 hit.
    PS00624. GMC_OXRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SBW25.

    Entry informationi

    Entry nameiBETA_PSEFS
    AccessioniPrimary (citable) accession number: C3K3D3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3