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Protein

Kynurenine formamidase

Gene

kynB

Organism
Pseudomonas fluorescens (strain SBW25)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.UniRule annotationSAAS annotation

Catalytic activityi

N-formyl-L-kynurenine + H2O = formate + L-kynurenine.UniRule annotationSAAS annotation

Pathwayi: L-tryptophan degradation via kynurenine pathway

This protein is involved in step 2 of the subpathway that synthesizes L-kynurenine from L-tryptophan.UniRule annotationSAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tryptophan 2,3-dioxygenase (kynA)
  2. Kynurenine formamidase (kynB)
This subpathway is part of the pathway L-tryptophan degradation via kynurenine pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-kynurenine from L-tryptophan, the pathway L-tryptophan degradation via kynurenine pathway and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processTryptophan catabolismUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00333; UER00454.

Names & Taxonomyi

Protein namesi
Recommended name:
Kynurenine formamidaseUniRule annotation (EC:3.5.1.9UniRule annotation)
Short name:
KFAUniRule annotation
Short name:
KFaseUniRule annotation
Alternative name(s):
ArylformamidaseUniRule annotation
N-formylkynurenine formamidaseUniRule annotation
Short name:
FKFUniRule annotation
Gene namesi
Name:kynBUniRule annotation
Ordered Locus Names:PFLU_5199Imported
OrganismiPseudomonas fluorescens (strain SBW25)Imported
Taxonomic identifieri216595 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002332 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi216595.PFLU5199.

Structurei

3D structure databases

ProteinModelPortaliC3K207.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KynB family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4107VWA. Bacteria.
COG1878. LUCA.
KOiK07130.
OMAiCPVNVGR.
OrthoDBiPOG091H0N8N.

Family and domain databases

HAMAPiMF_01969. KynB. 1 hit.
InterProiView protein in InterPro
IPR007325. KFase.
IPR017484. Kynurenine_formamidase_bac.
PfamiView protein in Pfam
PF04199. Cyclase. 1 hit.
TIGRFAMsiTIGR03035. trp_arylform. 1 hit.

Sequencei

Sequence statusi: Complete.

C3K207-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPIKTWWDI SPPLSTATPT WPGDTPFQEE RVWQFGPECP VNVGRITLSP
60 70 80 90 100
HTGAHVDAPL HYSADGAPIG EVSLDVYMGP CRVLHCLDSG ALVQPHQLEG
110 120 130 140 150
RVDNVPERVL LRTYPQAPLT EWDADFTAIA PQTIELLASL GVRLIGIDTP
160 170 180 190 200
SLDPQQSKTM DSHNAVARHG MAILEGIVLD DVPEGDYELI ALPLRFAHLD
210
ASPVRAILRP LKEPTR
Length:216
Mass (Da):23,695
Last modified:June 16, 2009 - v1
Checksum:iD54D84404CA0D431
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM181176 Genomic DNA. Translation: CAY52267.1.
RefSeqiWP_015885871.1. NC_012660.1.

Genome annotation databases

EnsemblBacteriaiCAY52267; CAY52267; PFLU_5199.
KEGGipfs:PFLU_5199.
PATRICifig|216595.4.peg.5332.

Similar proteinsi

Entry informationi

Entry nameiC3K207_PSEFS
AccessioniPrimary (citable) accession number: C3K207
Entry historyiIntegrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: September 27, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported