Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Pseudomonas fluorescens (strain SBW25)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase (purL)
  2. Phosphoribosylformylglycinamidine cyclo-ligase (purM)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:PFLU_4499
OrganismiPseudomonas fluorescens (strain SBW25)
Taxonomic identifieri216595 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002332 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002128291 – 352Phosphoribosylformylglycinamidine cyclo-ligaseAdd BLAST352

Proteomic databases

PRIDEiC3K102.

Interactioni

Protein-protein interaction databases

STRINGi216595.PFLU4499.

Structurei

3D structure databases

ProteinModelPortaliC3K102.
SMRiC3K102.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiENOG4105CXB. Bacteria.
COG0150. LUCA.
KOiK01933.
OMAiNHCVNDI.
OrthoDBiPOG091H0128.

Family and domain databases

CDDicd02196. PurM. 1 hit.
Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS. 1 hit.
InterProiView protein in InterPro
IPR010918. PurM-like_C_dom.
IPR036676. PurM-like_C_sf.
IPR016188. PurM-like_N.
IPR036921. PurM-like_N_sf.
IPR004733. PurM_cligase.
PANTHERiPTHR10520. PTHR10520. 1 hit.
PfamiView protein in Pfam
PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

C3K102-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKQPSLSYK DAGVDIDAGE ALVERIKSVA KRTARPEVMG GLGGFGALCE
60 70 80 90 100
IPAGYKQPVL VSGTDGVGTK LRLALNLNKH DTIGIDLVAM CVNDLVVCGA
110 120 130 140 150
EPLFFLDYYA TGKLNVDTAA QVVTGIGAGC ELSGCSLVGG ETAEMPGMYE
160 170 180 190 200
GEDYDLAGFC VGVVEKAEII DGSKVAAGDA LLALPSSGPH SNGYSLIRKI
210 220 230 240 250
IEVSGADIEN TQLDGKPLTD LLMAPTRIYV KPLLKLIKDT GAVKAMAHIT
260 270 280 290 300
GGGLLDNIPR VLPKGAQAIV DVASWQRPAV FDWLQEKGNV DETEMHRVLN
310 320 330 340 350
CGVGMVICVA QEHVETALNV LREAGEQPWV IGQIATAPEG AAQVELKNLK

AH
Length:352
Mass (Da):36,974
Last modified:June 16, 2009 - v1
Checksum:i92FD892517A854D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM181176 Genomic DNA. Translation: CAY51197.1.
RefSeqiWP_015885248.1. NC_012660.1.

Genome annotation databases

EnsemblBacteriaiCAY51197; CAY51197; PFLU_4499.
KEGGipfs:PFLU_4499.

Similar proteinsi

Entry informationi

Entry nameiPUR5_PSEFS
AccessioniPrimary (citable) accession number: C3K102
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: November 22, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families