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Protein

L-lactate dehydrogenase

Gene

lldD

Organism
Pseudomonas fluorescens (strain SBW25)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.UniRule annotation

Catalytic activityi

(S)-lactate + an oxidized electron acceptor = pyruvate + a reduced electron acceptor.UniRule annotation

Cofactori

FMNUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei24SubstrateUniRule annotation1
Binding sitei106FMNUniRule annotation1
Binding sitei127FMNUniRule annotation1
Binding sitei129SubstrateUniRule annotation1
Binding sitei155FMNUniRule annotation1
Binding sitei164SubstrateUniRule annotation1
Binding sitei251FMNUniRule annotation1
Active sitei275Proton acceptorUniRule annotation1
Binding sitei278SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi306 – 330FMNUniRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFlavoprotein, FMN

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.-.-UniRule annotation)
Gene namesi
Name:lldDUniRule annotation
Ordered Locus Names:PFLU_4305
OrganismiPseudomonas fluorescens (strain SBW25)
Taxonomic identifieri216595 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002332 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003834341 – 380L-lactate dehydrogenaseAdd BLAST380

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi216595.PFLU4305.

Structurei

3D structure databases

ProteinModelPortaliC3K053.
SMRiC3K053.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 380FMN hydroxy acid dehydrogenaseUniRule annotationAdd BLAST380

Sequence similaritiesi

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DMF. Bacteria.
COG1304. LUCA.
KOiK00101.
OrthoDBiPOG091H00L7.

Family and domain databases

CDDicd02809. alpha_hydroxyacid_oxid_FMN. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01559. L_lact_dehydr. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
IPR020920. LldD.
PfamiView protein in Pfam
PF01070. FMN_dh. 1 hit.
PIRSFiPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEiView protein in PROSITE
PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.

Sequencei

Sequence statusi: Complete.

C3K053-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIISSASDYR AAAQRKLPRF LFDYIDGGAY AEHTMRANSS DLAEISLRQR
60 70 80 90 100
ILRNVDNLSL KTTVFGQELD MPVILSPVGL TGMYARRGEV QAAKAAANKG
110 120 130 140 150
VPFCLSTVSV CPIEEVASQS ARAIWFQLYV LKDRGFMRNA LERAQAAGVT
160 170 180 190 200
TLVFTVDMPT PGARYRDAHS GMSGPFAAQR RMLQAMTKPQ WAFDVGLMGR
210 220 230 240 250
PHDLGNISKY LGKPTHLEDY IGWLANNFDP SISWKDLEWI REFWKGPMII
260 270 280 290 300
KGILDPQDAK DAVSFGADGI VVSNHGGRQL DGVLSTAKAL PPIADAVGDD
310 320 330 340 350
LTVLVDSGIR SGLDVVRMLA LGAKACLLGR ASAYALAADG QNGVENLLDI
360 370 380
FAKEMRVAMT LTGVTSIEQI DHTTLVGQRQ
Length:380
Mass (Da):41,302
Last modified:September 22, 2009 - v2
Checksum:i20318AA7EB359D6F
GO

Sequence cautioni

The sequence CAY50890 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM181176 Genomic DNA. Translation: CAY50890.1. Different initiation.
RefSeqiWP_043205692.1. NC_012660.1.

Genome annotation databases

EnsemblBacteriaiCAY50890; CAY50890; PFLU_4305.
KEGGipfs:PFLU_4305.
PATRICifig|216595.4.peg.4448.

Similar proteinsi

Entry informationi

Entry nameiLLDD_PSEFS
AccessioniPrimary (citable) accession number: C3K053
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 22, 2009
Last modified: August 30, 2017
This is version 46 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families