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C3JYR1 (GCSP_PSEFS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:PFLU_4897
OrganismPseudomonas fluorescens (strain SBW25) [Complete proteome] [HAMAP]
Taxonomic identifier216595 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length946 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 946946Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000212656

Amino acid modifications

Modified residue7001N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
C3JYR1 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: CE2F89AF47C44C59

FASTA946102,240
        10         20         30         40         50         60 
MTVNLTTANE FIARHIGPRQ EDEQHMLASL GFDSLEALSA SVIPESIKGT SVLGLEDGLS 

        70         80         90        100        110        120 
EAEALAKIKA IAGQNQLFKT YIGQGYYNCH TPSPILRNLL ENPAWYTAYT PYQPEISQGR 

       130        140        150        160        170        180 
LEALLNFQTL ISDLTGLPIA NASLLDEATA AAEAMTFCKR LSKNKGSNAF FASIHSHPQT 

       190        200        210        220        230        240 
LDVLRTRAEP LGIDVVVGDE RELTDVSAFF GALLQYPASN GDVFDYRALT ERFHASNALV 

       250        260        270        280        290        300 
AVAADLLALT LLTPPGEFGA DVAIGSAQRF GVPLGFGGPH AAYFSTKDAF KRDMPGRLVG 

       310        320        330        340        350        360 
VSVDRFGKPA LRLAMQTREQ HIRREKATSN ICTAQVLLAN IASMYAVYHG PKGLTQIAQR 

       370        380        390        400        410        420 
IHQLTAILAK GLTALGQKVE QEHFFDTLTL NTGANTATLH DKARAQRINL RVVDAERLGV 

       430        440        450        460        470        480 
SVDETTTQAD IETLWAIFAD GKALPDFAAN VDSTLPAALL RQSPILSHPV FNRYHSETEL 

       490        500        510        520        530        540 
MRYLRKLADK DLALDRTMIP LGSCTMKLNA ASEMIPVTWA EFGALHPFAP AEQSAGYLQL 

       550        560        570        580        590        600 
TSDLEAMLCA ATGYDAISLQ PNAGSQGEYA GLLAIRAYHQ SRGEERRDIC LIPSSAHGTN 

       610        620        630        640        650        660 
PATANMAGMR VVVTACDARG NVDIEDLRAK AIEHRDHLAA LMITYPSTHG VFEEGIREIC 

       670        680        690        700        710        720 
GIIHDNGGQV YIDGANMNAM VGLCAPGKFG GDVSHLNLHK TFCIPHGGGG PGVGPIGVKS 

       730        740        750        760        770        780 
HLTPFLPGHA AMERKEGAVC AAPFGSASIL PITWMYISMM GGAGLKRASQ LAILNANYIS 

       790        800        810        820        830        840 
RRLEEHYPVL YTGSNGLVAH ECILDLRPLK DSSGISVDDV AKRLIDFGFH APTMSFPVAG 

       850        860        870        880        890        900 
TLMIEPTESE SKEELDRFCD AMIAIREEIR AVENGTLDKD DNPLKNAPHT AAELVGEWSH 

       910        920        930        940 
PYSREQAVYP VASLIEGKYW PPVGRVDNVF GDRNLVCACP SIESYA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM181176 Genomic DNA. Translation: CAY51790.1.
RefSeqYP_002874403.1. NC_012660.1.

3D structure databases

ProteinModelPortalC3JYR1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING216595.PFLU4897.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAY51790; CAY51790; PFLU_4897.
GeneID7820855.
KEGGpfs:PFLU4897.
PATRIC19903894. VBIPseFlu98510_5030.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
KOK00281.
OMAERRDICL.
OrthoDBEOG6HMXDX.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_PSEFS
AccessionPrimary (citable) accession number: C3JYR1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families