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C3JYR1

- GCSP_PSEFS

UniProt

C3JYR1 - GCSP_PSEFS

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Pseudomonas fluorescens (strain SBW25)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:PFLU_4897
    OrganismiPseudomonas fluorescens (strain SBW25)
    Taxonomic identifieri216595 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002332: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 946946Glycine dehydrogenase (decarboxylating)PRO_1000212656Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei700 – 7001N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi216595.PFLU4897.

    Structurei

    3D structure databases

    ProteinModelPortaliC3JYR1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    KOiK00281.
    OMAiERRDICL.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C3JYR1-1 [UniParc]FASTAAdd to Basket

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    MTVNLTTANE FIARHIGPRQ EDEQHMLASL GFDSLEALSA SVIPESIKGT    50
    SVLGLEDGLS EAEALAKIKA IAGQNQLFKT YIGQGYYNCH TPSPILRNLL 100
    ENPAWYTAYT PYQPEISQGR LEALLNFQTL ISDLTGLPIA NASLLDEATA 150
    AAEAMTFCKR LSKNKGSNAF FASIHSHPQT LDVLRTRAEP LGIDVVVGDE 200
    RELTDVSAFF GALLQYPASN GDVFDYRALT ERFHASNALV AVAADLLALT 250
    LLTPPGEFGA DVAIGSAQRF GVPLGFGGPH AAYFSTKDAF KRDMPGRLVG 300
    VSVDRFGKPA LRLAMQTREQ HIRREKATSN ICTAQVLLAN IASMYAVYHG 350
    PKGLTQIAQR IHQLTAILAK GLTALGQKVE QEHFFDTLTL NTGANTATLH 400
    DKARAQRINL RVVDAERLGV SVDETTTQAD IETLWAIFAD GKALPDFAAN 450
    VDSTLPAALL RQSPILSHPV FNRYHSETEL MRYLRKLADK DLALDRTMIP 500
    LGSCTMKLNA ASEMIPVTWA EFGALHPFAP AEQSAGYLQL TSDLEAMLCA 550
    ATGYDAISLQ PNAGSQGEYA GLLAIRAYHQ SRGEERRDIC LIPSSAHGTN 600
    PATANMAGMR VVVTACDARG NVDIEDLRAK AIEHRDHLAA LMITYPSTHG 650
    VFEEGIREIC GIIHDNGGQV YIDGANMNAM VGLCAPGKFG GDVSHLNLHK 700
    TFCIPHGGGG PGVGPIGVKS HLTPFLPGHA AMERKEGAVC AAPFGSASIL 750
    PITWMYISMM GGAGLKRASQ LAILNANYIS RRLEEHYPVL YTGSNGLVAH 800
    ECILDLRPLK DSSGISVDDV AKRLIDFGFH APTMSFPVAG TLMIEPTESE 850
    SKEELDRFCD AMIAIREEIR AVENGTLDKD DNPLKNAPHT AAELVGEWSH 900
    PYSREQAVYP VASLIEGKYW PPVGRVDNVF GDRNLVCACP SIESYA 946
    Length:946
    Mass (Da):102,240
    Last modified:June 16, 2009 - v1
    Checksum:iCE2F89AF47C44C59
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM181176 Genomic DNA. Translation: CAY51790.1.
    RefSeqiYP_002874403.1. NC_012660.1.

    Genome annotation databases

    EnsemblBacteriaiCAY51790; CAY51790; PFLU_4897.
    GeneIDi7820855.
    KEGGipfs:PFLU4897.
    PATRICi19903894. VBIPseFlu98510_5030.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM181176 Genomic DNA. Translation: CAY51790.1 .
    RefSeqi YP_002874403.1. NC_012660.1.

    3D structure databases

    ProteinModelPortali C3JYR1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 216595.PFLU4897.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAY51790 ; CAY51790 ; PFLU_4897 .
    GeneIDi 7820855.
    KEGGi pfs:PFLU4897.
    PATRICi 19903894. VBIPseFlu98510_5030.

    Phylogenomic databases

    eggNOGi COG1003.
    KOi K00281.
    OMAi ERRDICL.
    OrthoDBi EOG6HMXDX.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SBW25.

    Entry informationi

    Entry nameiGCSP_PSEFS
    AccessioniPrimary (citable) accession number: C3JYR1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3