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C3JYR1

- GCSP_PSEFS

UniProt

C3JYR1 - GCSP_PSEFS

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, PFLU_4897
Organism
Pseudomonas fluorescens (strain SBW25)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:PFLU_4897
OrganismiPseudomonas fluorescens (strain SBW25)
Taxonomic identifieri216595 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002332: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 946946Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_1000212656Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei700 – 7001N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi216595.PFLU4897.

Structurei

3D structure databases

ProteinModelPortaliC3JYR1.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
KOiK00281.
OMAiERRDICL.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

C3JYR1-1 [UniParc]FASTAAdd to Basket

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MTVNLTTANE FIARHIGPRQ EDEQHMLASL GFDSLEALSA SVIPESIKGT    50
SVLGLEDGLS EAEALAKIKA IAGQNQLFKT YIGQGYYNCH TPSPILRNLL 100
ENPAWYTAYT PYQPEISQGR LEALLNFQTL ISDLTGLPIA NASLLDEATA 150
AAEAMTFCKR LSKNKGSNAF FASIHSHPQT LDVLRTRAEP LGIDVVVGDE 200
RELTDVSAFF GALLQYPASN GDVFDYRALT ERFHASNALV AVAADLLALT 250
LLTPPGEFGA DVAIGSAQRF GVPLGFGGPH AAYFSTKDAF KRDMPGRLVG 300
VSVDRFGKPA LRLAMQTREQ HIRREKATSN ICTAQVLLAN IASMYAVYHG 350
PKGLTQIAQR IHQLTAILAK GLTALGQKVE QEHFFDTLTL NTGANTATLH 400
DKARAQRINL RVVDAERLGV SVDETTTQAD IETLWAIFAD GKALPDFAAN 450
VDSTLPAALL RQSPILSHPV FNRYHSETEL MRYLRKLADK DLALDRTMIP 500
LGSCTMKLNA ASEMIPVTWA EFGALHPFAP AEQSAGYLQL TSDLEAMLCA 550
ATGYDAISLQ PNAGSQGEYA GLLAIRAYHQ SRGEERRDIC LIPSSAHGTN 600
PATANMAGMR VVVTACDARG NVDIEDLRAK AIEHRDHLAA LMITYPSTHG 650
VFEEGIREIC GIIHDNGGQV YIDGANMNAM VGLCAPGKFG GDVSHLNLHK 700
TFCIPHGGGG PGVGPIGVKS HLTPFLPGHA AMERKEGAVC AAPFGSASIL 750
PITWMYISMM GGAGLKRASQ LAILNANYIS RRLEEHYPVL YTGSNGLVAH 800
ECILDLRPLK DSSGISVDDV AKRLIDFGFH APTMSFPVAG TLMIEPTESE 850
SKEELDRFCD AMIAIREEIR AVENGTLDKD DNPLKNAPHT AAELVGEWSH 900
PYSREQAVYP VASLIEGKYW PPVGRVDNVF GDRNLVCACP SIESYA 946
Length:946
Mass (Da):102,240
Last modified:June 16, 2009 - v1
Checksum:iCE2F89AF47C44C59
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM181176 Genomic DNA. Translation: CAY51790.1.
RefSeqiYP_002874403.1. NC_012660.1.

Genome annotation databases

EnsemblBacteriaiCAY51790; CAY51790; PFLU_4897.
GeneIDi7820855.
KEGGipfs:PFLU4897.
PATRICi19903894. VBIPseFlu98510_5030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM181176 Genomic DNA. Translation: CAY51790.1 .
RefSeqi YP_002874403.1. NC_012660.1.

3D structure databases

ProteinModelPortali C3JYR1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216595.PFLU4897.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAY51790 ; CAY51790 ; PFLU_4897 .
GeneIDi 7820855.
KEGGi pfs:PFLU4897.
PATRICi 19903894. VBIPseFlu98510_5030.

Phylogenomic databases

eggNOGi COG1003.
KOi K00281.
OMAi ERRDICL.
OrthoDBi EOG6HMXDX.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SBW25.

Entry informationi

Entry nameiGCSP_PSEFS
AccessioniPrimary (citable) accession number: C3JYR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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