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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Pseudomonas fluorescens (strain SBW25)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:PFLU_4897
OrganismiPseudomonas fluorescens (strain SBW25)
Taxonomic identifieri216595 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002332 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 946946Glycine dehydrogenase (decarboxylating)PRO_1000212656Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei700 – 7001N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi216595.PFLU4897.

Structurei

3D structure databases

ProteinModelPortaliC3JYR1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
KOiK00281.
OMAiPHYKTLY.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

C3JYR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVNLTTANE FIARHIGPRQ EDEQHMLASL GFDSLEALSA SVIPESIKGT
60 70 80 90 100
SVLGLEDGLS EAEALAKIKA IAGQNQLFKT YIGQGYYNCH TPSPILRNLL
110 120 130 140 150
ENPAWYTAYT PYQPEISQGR LEALLNFQTL ISDLTGLPIA NASLLDEATA
160 170 180 190 200
AAEAMTFCKR LSKNKGSNAF FASIHSHPQT LDVLRTRAEP LGIDVVVGDE
210 220 230 240 250
RELTDVSAFF GALLQYPASN GDVFDYRALT ERFHASNALV AVAADLLALT
260 270 280 290 300
LLTPPGEFGA DVAIGSAQRF GVPLGFGGPH AAYFSTKDAF KRDMPGRLVG
310 320 330 340 350
VSVDRFGKPA LRLAMQTREQ HIRREKATSN ICTAQVLLAN IASMYAVYHG
360 370 380 390 400
PKGLTQIAQR IHQLTAILAK GLTALGQKVE QEHFFDTLTL NTGANTATLH
410 420 430 440 450
DKARAQRINL RVVDAERLGV SVDETTTQAD IETLWAIFAD GKALPDFAAN
460 470 480 490 500
VDSTLPAALL RQSPILSHPV FNRYHSETEL MRYLRKLADK DLALDRTMIP
510 520 530 540 550
LGSCTMKLNA ASEMIPVTWA EFGALHPFAP AEQSAGYLQL TSDLEAMLCA
560 570 580 590 600
ATGYDAISLQ PNAGSQGEYA GLLAIRAYHQ SRGEERRDIC LIPSSAHGTN
610 620 630 640 650
PATANMAGMR VVVTACDARG NVDIEDLRAK AIEHRDHLAA LMITYPSTHG
660 670 680 690 700
VFEEGIREIC GIIHDNGGQV YIDGANMNAM VGLCAPGKFG GDVSHLNLHK
710 720 730 740 750
TFCIPHGGGG PGVGPIGVKS HLTPFLPGHA AMERKEGAVC AAPFGSASIL
760 770 780 790 800
PITWMYISMM GGAGLKRASQ LAILNANYIS RRLEEHYPVL YTGSNGLVAH
810 820 830 840 850
ECILDLRPLK DSSGISVDDV AKRLIDFGFH APTMSFPVAG TLMIEPTESE
860 870 880 890 900
SKEELDRFCD AMIAIREEIR AVENGTLDKD DNPLKNAPHT AAELVGEWSH
910 920 930 940
PYSREQAVYP VASLIEGKYW PPVGRVDNVF GDRNLVCACP SIESYA
Length:946
Mass (Da):102,240
Last modified:June 16, 2009 - v1
Checksum:iCE2F89AF47C44C59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM181176 Genomic DNA. Translation: CAY51790.1.
RefSeqiWP_015885598.1. NC_012660.1.
YP_002874403.1. NC_012660.1.

Genome annotation databases

EnsemblBacteriaiCAY51790; CAY51790; PFLU_4897.
GeneIDi7820855.
KEGGipfs:PFLU4897.
PATRICi19903894. VBIPseFlu98510_5030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM181176 Genomic DNA. Translation: CAY51790.1.
RefSeqiWP_015885598.1. NC_012660.1.
YP_002874403.1. NC_012660.1.

3D structure databases

ProteinModelPortaliC3JYR1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi216595.PFLU4897.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAY51790; CAY51790; PFLU_4897.
GeneIDi7820855.
KEGGipfs:PFLU4897.
PATRICi19903894. VBIPseFlu98510_5030.

Phylogenomic databases

eggNOGiCOG1003.
KOiK00281.
OMAiPHYKTLY.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SBW25.

Entry informationi

Entry nameiGCSP_PSEFS
AccessioniPrimary (citable) accession number: C3JYR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: May 27, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.