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C3JXY7 (ASTD_PSEFS) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-succinylglutamate 5-semialdehyde dehydrogenase
EC=1.2.1.71
Alternative name(s):
Succinylglutamic semialdehyde dehydrogenase
Short name=SGSD
Gene names
Name:astD
Ordered Locus Names:PFLU_4754
OrganismPseudomonas fluorescens (strain SBW25) [Complete proteome] [HAMAP]
Taxonomic identifier216595 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length488 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity. HAMAP MF_01174

Catalytic activity

N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174

Pathway

Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174

Sequence similarities

Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
   Biological processArginine metabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionsuccinylglutamate-semialdehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 488488N-succinylglutamate 5-semialdehyde dehydrogenase HAMAP MF_01174
PRO_1000213743

Regions

Nucleotide binding221 – 2266NAD By similarity

Sites

Active site2441 By similarity
Active site2781 By similarity

Sequences

Sequence LengthMass (Da)Tools
C3JXY7 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: 4A3B5764CB4BA347

FASTA48851,512
        10         20         30         40         50         60 
MNSLYIAGSW LAGQGELFES RNPVTQHVLW AGNGATAEQV ESAVQAARQA FPAWARRPLE 

        70         80         90        100        110        120 
ERISVLETFA ATLKNRADEI ARCIGEETGK PLWESVTEVT SMANKIAISV QSYRERTGEK 

       130        140        150        160        170        180 
SGPLGDATAV LRHKPHGVVA VFGPYNFPGH LPNGHIVPAL LAGNTVLFKP SELTPKVAEL 

       190        200        210        220        230        240 
TVQCWIEAGL PAGVLNLLQG ARETGIALAA NPGIDGLFFT GSSRTGNHLH QQFSGRPDKI 

       250        260        270        280        290        300 
LALEMGGNNP LVVDEVADVD AAVYTIIQSA FISAGQRCTC ARRLLVPEGA WGDALLARLV 

       310        320        330        340        350        360 
AVSATIAVGA FDQQPAPFMG SVISLAAAKA LMDAQELMLA NGAVALLEMT QPQDQAALLT 

       370        380        390        400        410        420 
PGIIDVTGVT AREDEELFGP LLQVIRYADF AAAIAEANNT QYGLAAGLLS DSEARYQQFW 

       430        440        450        460        470        480 
LESRAGIVNW NKQLTGAAST APFGGVGASG NHRASAYYAA DYCAYPVASL ETPSLVVPAT 


LTPGVRLS

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM181176 Genomic DNA. Translation: CAY51578.1.
RefSeqYP_002874272.1. NC_012660.1.

3D structure databases

ProteinModelPortalC3JXY7.
ModBaseSearch...

Protein-protein interaction databases

STRINGC3JXY7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7822286.
GenomeReviewsGene locus PFLU_4754 in contig AM181176_GR.
KEGGpfs:PFLU4754.
PATRIC19903610. VBIPseFlu98510_4888.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAMTQRDPR.
ProtClustDBPRK09457.

Enzyme and pathway databases

BioCycPFLU216595:PFLU4754-MONOMER.

Family and domain databases

HAMAPMF_01174. Aldedh_AstD.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR017649. SuccinylGlu_semiald_DH_AstD.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK06447.
PANTHERPTHR11699:SF24. PTHR11699:SF24. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR03240. Arg_catab_astD. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASTD_PSEFS
AccessionPrimary (citable) accession number: C3JXY7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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