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C2YEP8 (C2YEP8_BACCE) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase HAMAP MF_00172
EC=2.1.1.14 HAMAP MF_00172
Alternative name(s):
Cobalamin-independent methionine synthase HAMAP MF_00172
Methionine synthase, vitamin-B12 independent isozyme HAMAP MF_00172
Gene names
Name:metE HAMAP MF_00172
ORF Names:bcere0027_36710 EMBL EEL75013.1
OrganismBacillus cereus AH676 EMBL EEL75013.1
Taxonomic identifier526991 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length762 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. HAMAP MF_00172 SAAS SAAS013215

Catalytic activity

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. HAMAP MF_00172 SAAS SAAS013215

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00172

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. HAMAP MF_00172 SAAS SAAS013215

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family. HAMAP MF_00172

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding6451Zinc By similarity HAMAP MF_00172
Metal binding6471Zinc By similarity HAMAP MF_00172
Metal binding7301Zinc By similarity HAMAP MF_00172

Sequences

Sequence LengthMass (Da)Tools
C2YEP8 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: 87BDE0669F3092A5

FASTA76287,185
        10         20         30         40         50         60 
MAIQTSNLGY PRIGLQREWK KTLEAFWSNK IDEEQFLTTM KEIRLQHVKV QQEKGIELIP 

        70         80         90        100        110        120 
IGDFTYYDHV LDTAYMLGFI PSRFSEFTSY LDVYFAMARG SKDHVASEMT KWFNTNYHYI 

       130        140        150        160        170        180 
VPEYEEGLQI SLKDNRPLRL YEEAKQELGV DGKPVILGPY TFLKLAKGYT QEQFPTILKQ 

       190        200        210        220        230        240 
LVAPYVQLLS ELHAAGAPAI QVDEPIFASL TKKEVQQAKE IYEAIRKEVP NATLLLQTYF 

       250        260        270        280        290        300 
DSVEENYEEI ITFPVSGIGL DFIHGKEGNL NAISKYGFPA DKTLAVGCID GRNIWRADLD 

       310        320        330        340        350        360 
EVLELFTTLQ KQVQTKDIIV QPSCSLLHTP IDKTEETHLS TELFDALAFA NQKLEELVLI 

       370        380        390        400        410        420 
HSALTQGTES ISNELETYRN VHHTIRSSAA RNREDVKAAR TALKEEDFSR PLPFEKRYEL 

       430        440        450        460        470        480 
QQVALELPLL PTTTIGSFPQ TTEVRQTRKE WRNGVISNEQ YEQFIEKETE KWIRYQEEIG 

       490        500        510        520        530        540 
LDVLVHGEFE RTDMVEYFGE RLAGFSFTKN GWVQSYGSRC VKPPVIYGDV AFINGMTIKE 

       550        560        570        580        590        600 
TVYAQSLTEK VVKGMLTGPV TILNWSFVRN DIPRKEVSYQ IALALRHEIE LLESSGIRVI 

       610        620        630        640        650        660 
QVDEPALREG MPLKEKDWDA YITWAVQSFL LATSSVANET QIHTHMCYSN FEDIVDAIRA 

       670        680        690        700        710        720 
LDADVISIET SRSHGEFIDT LKHTTYEKGI GLGVYDIHSP RVPSKDEMYK IVEQSLEVCD 

       730        740        750        760 
PKYFWINPDC GLKTRRTEEV IPALEHMVQA AKDARSLLKT NA

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References

[1]"Annotation of the Bacillus cereus AH676 genome."
Read T.D., Akmal A., Bishop-Lilly K., Chen P.E., Cook C., Kiley M.P., Lentz S., Mateczun A., Nagarajan N., Nolan N., Osborne B.I., Pop M., Sozhamannan S., Stewart A.C., Sulakvelidze A., Thomason B., Willner K., Zwick M.E.
Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: AH676 EMBL EEL75013.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		ACMQ01000172 Genomic DNA. Translation: EEL75013.1.

3D structure databases

ProteinModelPortalC2YEP8.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000198522; EBBACP00000195014; EBBACG00000199235.
PATRIC24853080. VBIBacCer88826_1572.

Family and domain databases

HAMAPMF_00172. Meth_synth.
[Tree]
InterProIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Methionine_synth.
[Graphical view]
PfamPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsTIGR01371. Met_syn_B12ind. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC2YEP8_BACCE
AccessionPrimary (citable) accession number: C2YEP8
Entry history
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: December 14, 2011
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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