C2U8I0 (C2U8I0_BACCE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Bifunctional purine biosynthesis protein PurH HAMAP MF_00139

Gene names

Name:	purH HAMAP MF_00139
ORF Names:	bcere0018_2530 EMBL EEL30680.1

Organism

Bacillus cereus Rock1-15 EMBL EEL30680.1

Taxonomic identifier

526982 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	511 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP MF_00139 SAAS SAAS002695 IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP MF_00139 SAAS SAAS002695
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP MF_00139 SAAS SAAS002695 Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1. HAMAP MF_00139 SAAS SAAS002695
Domain	The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP MF_00139
Sequence similarities	Belongs to the PurH family. HAMAP MF_00139

Ontologies

Keywords
Biological process	Purine biosynthesis HAMAP MF_00139 SAAS SAAS002695
Molecular function	Hydrolase HAMAP MF_00139 SAAS SAAS002695 EMBL EEL30680.1 Transferase HAMAP MF_00139 SAAS SAAS002695
Technical term	Multifunctional enzyme HAMAP MF_00139 SAAS SAAS002695
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	IMP cyclohydrolase activity Inferred from electronic annotation. Source: HAMAP phosphoribosylaminoimidazolecarboxamide formyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C2U8I0 [UniParc]. Last modified June 16, 2009. Version 1. Checksum: 35601DD0B3417010	FASTA	511	55,574
	10 20 30 40 50 60 MKKRALVSVS DKTGVVEFVK GLLEQGIEVI STGGTKKLLE ENGLQVIGIS EVTGFPEIMD 70 80 90 100 110 120 GRVKTLHPNI HGGLLAVRDN ETHVTQMNEL GMEPIDFVVV NLYPFKETIA KPDVTFADAI 130 140 150 160 170 180 ENIDIGGPTM IRSAAKNHKF VSVIVDPVDY DIVLAELKEN GEVAEETKRK LAAKVFRHTA 190 200 210 220 230 240 AYDALISNYL TEQMGEESPE TLTVTFEKKQ DLRYGENPHQ KATFYKAPFA ATSSVAYAEQ 250 260 270 280 290 300 LHGKELSYNN INDADAALSI VKEFTEPAVV AVKHMNPCGV GVGTDIHEAY TRAYEADPVS 310 320 330 340 350 360 IFGGIIAANR EIDKATAEKL HEIFLEIVIA PSFSQEALEV LQSKKNLRLL TINIEKATSA 370 380 390 400 410 420 SKKLTSVQGG LLVQEEDTLS LDESTISIPT KREPSEQEWK DLKLAWKVVK HVKSNAIVLA 430 440 450 460 470 480 KDDMTIGVGA GQMNRVGSAK IAITQAGEKA QGSALASDAF FPMPDTLEEA AKAGITAIIQ 490 500 510 PGGSIRDEDS IKVADTYGIA MVFTGVRHFK H

References

[1]

"Annotation of the Bacillus cereus Rock1-15 genome." Read T.D., Akmal A., Bishop-Lilly K., Chen P.E., Cook C., Kiley M.P., Lentz S., Mateczun A., Nagarajan N., Nolan N., Osborne B.I., Pop M., Sozhamannan S., Stewart A.C., Sulakvelidze A., Thomason B., Willner K., Zwick M.E. Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Rock1-15 EMBL EEL30680.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	ACMH01000012 Genomic DNA. Translation: EEL30680.1.
3D structure databases
ProteinModelPortal	C2U8I0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000221932; EBBACP00000216697; EBBACG00000219457.
PATRIC	25012531. VBIBacCer37058_0789.
Family and domain databases
HAMAP	MF_00139. PurH. [Tree]
InterPro	IPR024051. AICAR_Tfase_dom. IPR002695. AICARFT_IMPCHas. IPR016193. Cytidine_deaminase-like. IPR011607. MGS-like_dom. [Graphical view]
Gene3D	G3DSA:3.40.140.20. G3DSA:3.40.140.20. 2 hits. G3DSA:3.40.50.1380. MGS-like_dom. 1 hit.
PANTHER	PTHR11692. AICARFT_IMPCHas. 1 hit.
Pfam	PF01808. AICARFT_IMPCHas. 1 hit. PF02142. MGS. 1 hit. [Graphical view]
PIRSF	PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMART	SM00798. AICARFT_IMPCHas. 1 hit. SM00851. MGS. 1 hit. [Graphical view]
SUPFAM	SSF53927. Cytidine_deaminase-like. 1 hit. SSF52335. MGS-like_dom. 1 hit.
TIGRFAMs	TIGR00355. PurH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C2U8I0_BACCE

Accession

Primary (citable) accession number: C2U8I0

Entry history

Integrated into UniProtKB/TrEMBL:	June 16, 2009
Last sequence update:	June 16, 2009
Last modified:	December 14, 2011
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)