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C2MR09 (C2MR09_BACCE) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase HAMAP MF_01684
Short name=MTA/SAH nucleosidase HAMAP MF_01684
Short name=MTAN HAMAP MF_01684
EC=3.2.2.9 HAMAP MF_01684
Alternative name(s):
5'-methylthioadenosine nucleosidase HAMAP MF_01684
S-adenosylhomocysteine nucleosidase HAMAP MF_01684
Gene names
Name:mtnN HAMAP MF_01684
ORF Names:bcere0001_40290 EMBL EEK43118.1
OrganismBacillus cereus m1293 EMBL EEK43118.1
Taxonomic identifier526973 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length231 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively By similarity. HAMAP MF_01684

Catalytic activity

S-adenosyl-L-homocysteine + H2O = S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine. HAMAP MF_01684 SAAS SAAS010049

S-methyl-5'-thioadenosine + H2O = S-methyl-5-thio-D-ribose + adenine. HAMAP MF_01684 SAAS SAAS010049

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2. HAMAP MF_01684

Sequence similarities

Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. HAMAP MF_01684

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region174 – 1752Substrate binding By similarity HAMAP MF_01684

Sites

Active site121Proton acceptor By similarity HAMAP MF_01684
Binding site781Substrate; via amide nitrogen By similarity HAMAP MF_01684
Binding site1981Substrate By similarity HAMAP MF_01684

Sequences

Sequence LengthMass (Da)Tools
C2MR09 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: 11F3ACE054DE48AC

FASTA23125,255
        10         20         30         40         50         60 
MRIAVIGAME EEVRILRDKL EQAETETVAG CEFTKGQLAG HEVILLKSGI GKVNAAMSTT 

        70         80         90        100        110        120 
ILLERYKPEK VINTGSAGGF HHSLNVGDVV ISTEVRHHDV DVTAFNYEYG QVPGMPPGFK 

       130        140        150        160        170        180 
ADEALVALAE KCMQAEENIQ VVKGMIATGD SFMSDPNRVA AIRDKFENLY AVEMEAAAVA 

       190        200        210        220        230 
QVCHQYEVPF VIIRALSDIA GKESNVSFDQ FLDQAALHST NFIVKVLEEL K

« Hide

References

[1]"Annotation of the Bacillus cereus m1293 genome."
Read T.D., Akmal A., Bishop-Lilly K., Chen P.E., Cook C., Kiley M.P., Lentz S., Mateczun A., Nagarajan N., Nolan N., Osborne B.I., Pop M., Sozhamannan S., Stewart A.C., Sulakvelidze A., Thomason B., Willner K., Zwick M.E.
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: M1293 EMBL EEK43118.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		ACLS01000102 Genomic DNA. Translation: EEK43118.1.

3D structure databases

ProteinModelPortalC2MR09.
SMRC2MR09. Positions 1-230.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000209958; EBBACP00000207456; EBBACG00000208301.
PATRIC25124888. VBIBacCer121715_0160.

Family and domain databases

HAMAPMF_01684. Salvage_tnN.
[Tree]
InterProIPR010049. MTA_SAH_Nsdase.
IPR018017. Nucleoside_phosphorylase.
IPR000845. Nucleoside_phosphorylase_d.
[Graphical view]
PANTHERPTHR21234. PNP_UDP. 1 hit.
PTHR21234:SF6. PTHR21234:SF6. 1 hit.
PfamPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
TIGRFAMsTIGR01704. MTA/SAH-Nsdase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC2MR09_BACCE
AccessionPrimary (citable) accession number: C2MR09
Entry history
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: December 14, 2011
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info