C2GUK4 (C2GUK4_BIFLN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137
EC=6.3.2.6 HAMAP MF_00137

Alternative name(s):
SAICAR synthetase HAMAP MF_00137

Gene names

Name:	purC HAMAP MF_00137 EMBL EEI81131.1
ORF Names:	HMPREF0175_0702 EMBL EEI81131.1

Organism

Bifidobacterium longum subsp. longum ATCC 55813 EMBL EEI81131.1

Taxonomic identifier

548480 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length	250 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137 SAAS SAAS001636
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137 SAAS SAAS001636
Sequence similarities	Belongs to the SAICAR synthetase family. HAMAP MF_00137 RuleBase RU004193
Caution	The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Ontologies

Keywords
Biological process	Purine biosynthesis HAMAP MF_00137 SAAS SAAS001636
Ligand	ATP-binding HAMAP MF_00137 SAAS SAAS001636 Nucleotide-binding
Molecular function	Ligase HAMAP MF_00137 SAAS SAAS001636 EMBL EEI81131.1
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C2GUK4 [UniParc]. Last modified June 16, 2009. Version 1. Checksum: 5874EA8DA5287E98	FASTA	250	28,220
	10 20 30 40 50 60 MEKLEKLYEG KAKQLYATDD PEVLWVEYKN TATAGDGEKK EDFTGKGRLN NLITTIIFDL 70 80 90 100 110 120 LKKRGIDSHL IKRVDDTGQL VRKVNMFPLE IVLRNVAAGH FCSRLGVEEG LPLKEPVLEY 130 140 150 160 170 180 FLKNDDLHDP FVNDDDLVAL GVCTREDLAE IAPLARKINE ALIEIFAKID VKLVDFKIEM 190 200 210 220 230 240 GRATDGTLLL ADEITPDSCR LWDQKDHSGK VEHLDKDLFR RGLGSIIPAY EEIEERLAEL 250 AKSEGIEVAE

References

[1]

Qin X., Bachman B., Battles P., Bell A., Bess C., Bickham C., Chaboub L., Chen D., Coyle M., Deiros D.R., Dinh H., Forbes L., Fowler G., Francisco L., Fu Q., Gubbala S., Hale W., Han Y. , Hemphill L., Highlander S.K., Hirani K., Hogues M., Jackson L., Jakkamsetti A., Javaid M., Jiang H., Korchina V., Kovar C., Lara F., Lee S., Mata R., Mathew T., Moen C., Morales K., Munidasa M., Nazareth L., Ngo R., Nguyen L., Okwuonu G., Ongeri F., Patil S., Petrosino J., Pham C., Pham P., Pu L.-L., Puazo M., Raj R., Reid J., Rouhana J., Saada N., Shang Y., Simmons D., Thornton R., Warren J., Weissenberger G., Zhang J., Zhang L., Zhou C., Zhu D., Muzny D., Worley K., Gibbs R. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC 55813 EMBL EEI81131.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	ACHI01000018 Genomic DNA. Translation: EEI81131.1.
3D structure databases
ProteinModelPortal	C2GUK4.
SMR	C2GUK4. Positions 2-238.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
PATRIC	36942184. VBIBifLon7869_0183.
Family and domain databases
HAMAP	MF_00137. SAICAR_synth. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR001636. SAICAR_synth. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR00081. PurC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C2GUK4_BIFLN

Accession

Primary (citable) accession number: C2GUK4

Entry history

Integrated into UniProtKB/TrEMBL:	June 16, 2009
Last sequence update:	June 16, 2009
Last modified:	January 25, 2012
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)