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C2C744

- C2C744_VIBCL

UniProt

C2C744 - C2C744_VIBCL

Protein
Submitted name:

Cytolysin and hemolysin HlyA Pore-forming toxin

Gene

VCG_000884

Organism
Vibrio cholerae 12129(1)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. cytolysis in other organism Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Cytolysin and hemolysin HlyA Pore-forming toxinImported
    Gene namesi
    ORF Names:VCG_000884Imported
    OrganismiVibrio cholerae 12129(1)Imported
    Taxonomic identifieri592313 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: InterPro

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-59627N.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3O44X-ray2.88A/B/C/D/E/F/G/H/I/J/K/L/M/N149-741[»]
    4GX7X-ray2.85A/B/C/D/E/F611-741[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    Gene3Di2.70.240.10. 1 hit.
    InterProiIPR022220. Hemolysin_N.
    IPR016183. Leukocidin/porin.
    IPR000772. Ricin_B_lectin.
    [Graphical view]
    PfamiPF12563. Hemolysin_N. 1 hit.
    PF07968. Leukocidin. 1 hit.
    PF00652. Ricin_B_lectin. 1 hit.
    [Graphical view]
    SMARTiSM00458. RICIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF50370. SSF50370. 1 hit.
    SSF56959. SSF56959. 1 hit.
    PROSITEiPS50231. RICIN_B_LECTIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C2C744-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKLNRCAIA IFTILSAISS PTLLANINEP SGEAADIISQ VADSHAIKYY    50
    NAADWQAEDN ALPSLAELRD LVINQQKRVL VDFSQISDAE GQAEMQAQFR 100
    KAYGVGFANQ FIVITEHKGE LLFTPFDQAQ EVDPQLLEAP RTARLLARSG 150
    FASPAPANSE TNTLPHVAFY ISVNRAISDE ECTFNNSWLW KNEKGSRPFC 200
    KDANISLIYR VNLERSLQYG IVGSATPDAK IVRISLDDDS TGAGIHLNDQ 250
    LGYRQFGASY TTLDAYFREW STDAIAQDYR FVFNASNNKA QILKTFPVDN 300
    INEKFERKEV SGFELGVTGG VEVSGDGPKA KLEARASYTQ SRWLTYNTQD 350
    YRIERNAKNA QAVSFTWNRQ QYATAESLLN RSTDALWVNT YPVDVNRISP 400
    LSYASFVPKM DVIYKASATE TGSTDFIIDS SVNIRPIYNG AYKHYYVVGA 450
    HQSYHGFEDT PRRRITKSAS FTVDWDHPVF TGGRPVNLQL ASFNNRCIQV 500
    DAQGRLTANM CDSQQSAQSF IYDQLGRYVS ASNTKLCLDG AALDALQPCN 550
    QNLTQRWEWR KGTDELTNVY SGESLGHDKQ TGELGLYASS NDAVSLRTIT 600
    AYTDVFNAQE SSPILGYTQG KMNQQRVGQD HRLYVRAGAA IDALGSASDL 650
    LVGGNGGSLS SVDLSGVKSI TATSGDFQYG GQQLVALTFT YQDGRQQTVG 700
    SKAYVTNAHE DRFDLPDAAK ITQLKIWADD WLVKGVQFDL N 741
    Length:741
    Mass (Da):81,991
    Last modified:June 16, 2009 - v1
    Checksum:i6013B78B64F4133F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACFQ01000009 Genomic DNA. Translation: EEN99657.1.

    Genome annotation databases

    EnsemblBacteriaiEEN99657; EEN99657; VCG_000884.
    PATRICi29690304. VBIVibCho6176_0900.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    ACFQ01000009 Genomic DNA. Translation: EEN99657.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3O44 X-ray 2.88 A/B/C/D/E/F/G/H/I/J/K/L/M/N 149-741 [» ]
    4GX7 X-ray 2.85 A/B/C/D/E/F 611-741 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-59627N.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai EEN99657 ; EEN99657 ; VCG_000884 .
    PATRICi 29690304. VBIVibCho6176_0900.

    Family and domain databases

    Gene3Di 2.70.240.10. 1 hit.
    InterProi IPR022220. Hemolysin_N.
    IPR016183. Leukocidin/porin.
    IPR000772. Ricin_B_lectin.
    [Graphical view ]
    Pfami PF12563. Hemolysin_N. 1 hit.
    PF07968. Leukocidin. 1 hit.
    PF00652. Ricin_B_lectin. 1 hit.
    [Graphical view ]
    SMARTi SM00458. RICIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50370. SSF50370. 1 hit.
    SSF56959. SSF56959. 1 hit.
    PROSITEi PS50231. RICIN_B_LECTIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome Assortment, Not Serogroup, Defines Vibrio cholerae Pandemic Strains."
      Los Alamos National Laboratory (LANL), National Microbial Pathogen Data Resource (NMPDR)
      Munk A.C., Tapia R., Green L., Rogers Y., Detter J.C., Bruce D., Brettin T.S., Colwell R.R., Huq A., Grim C.J., Hasan N.A., Bartels D., Vonstein V.
      Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 12129Imported.
    2. "Crystal structure of the Vibrio cholerae cytolysin heptamer reveals common features among disparate pore-forming toxins."
      De S., Olson R.
      Proc. Natl. Acad. Sci. U.S.A. 108:7385-7390(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.88 ANGSTROMS) OF 149-741.
    3. "Vibrio cholerae cytolysin recognizes the heptasaccharide core of complex N-glycans with nanomolar affinity."
      Levan S., De S., Olson R.
      J. Mol. Biol. 425:944-957(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 611-741.

    Entry informationi

    Entry nameiC2C744_VIBCL
    AccessioniPrimary (citable) accession number: C2C744
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 16, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3