C2C744 (C2C744_VIBCL) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Cytolysin and hemolysin HlyA Pore-forming toxin EMBL EEN99657.1

Gene names

ORF Names:

VCG_000884 EMBL EEN99657.1

Organism

Vibrio cholerae 12129(1) EMBL EEN99657.1

Taxonomic identifier

592313 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio › Vibrio cholerae

Protein attributes

Sequence length	741 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Ontologies

Keywords
Technical term	3D-structure PDB 3O44 PDB 4GX7
Gene Ontology (GO)
Biological_process	cytolysis in other organism Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C2C744 [UniParc]. Last modified June 16, 2009. Version 1. Checksum: 6013B78B64F4133F	FASTA	741	81,991
	10 20 30 40 50 60 MPKLNRCAIA IFTILSAISS PTLLANINEP SGEAADIISQ VADSHAIKYY NAADWQAEDN 70 80 90 100 110 120 ALPSLAELRD LVINQQKRVL VDFSQISDAE GQAEMQAQFR KAYGVGFANQ FIVITEHKGE 130 140 150 160 170 180 LLFTPFDQAQ EVDPQLLEAP RTARLLARSG FASPAPANSE TNTLPHVAFY ISVNRAISDE 190 200 210 220 230 240 ECTFNNSWLW KNEKGSRPFC KDANISLIYR VNLERSLQYG IVGSATPDAK IVRISLDDDS 250 260 270 280 290 300 TGAGIHLNDQ LGYRQFGASY TTLDAYFREW STDAIAQDYR FVFNASNNKA QILKTFPVDN 310 320 330 340 350 360 INEKFERKEV SGFELGVTGG VEVSGDGPKA KLEARASYTQ SRWLTYNTQD YRIERNAKNA 370 380 390 400 410 420 QAVSFTWNRQ QYATAESLLN RSTDALWVNT YPVDVNRISP LSYASFVPKM DVIYKASATE 430 440 450 460 470 480 TGSTDFIIDS SVNIRPIYNG AYKHYYVVGA HQSYHGFEDT PRRRITKSAS FTVDWDHPVF 490 500 510 520 530 540 TGGRPVNLQL ASFNNRCIQV DAQGRLTANM CDSQQSAQSF IYDQLGRYVS ASNTKLCLDG 550 560 570 580 590 600 AALDALQPCN QNLTQRWEWR KGTDELTNVY SGESLGHDKQ TGELGLYASS NDAVSLRTIT 610 620 630 640 650 660 AYTDVFNAQE SSPILGYTQG KMNQQRVGQD HRLYVRAGAA IDALGSASDL LVGGNGGSLS 670 680 690 700 710 720 SVDLSGVKSI TATSGDFQYG GQQLVALTFT YQDGRQQTVG SKAYVTNAHE DRFDLPDAAK 730 740 ITQLKIWADD WLVKGVQFDL N

References

[1]	"Genome Assortment, Not Serogroup, Defines Vibrio cholerae Pandemic Strains." Los Alamos National Laboratory (LANL), National Microbial Pathogen Data Resource (NMPDR) Munk A.C., Tapia R., Green L., Rogers Y., Detter J.C., Bruce D., Brettin T.S., Colwell R.R., Huq A., Grim C.J., Hasan N.A., Bartels D., Vonstein V. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: 12129 EMBL EEN99657.1.
[2]	"Crystal structure of the Vibrio cholerae cytolysin heptamer reveals common features among disparate pore-forming toxins." De S., Olson R. Proc. Natl. Acad. Sci. U.S.A. 108:7385-7390(2011) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.88 ANGSTROMS) OF 149-741.
[3]	"Vibrio cholerae Cytolysin Recognizes the Heptasaccharide Core of Complex N-Glycans with Nanomolar Affinity." Levan S., De S., Olson R. J. Mol. Biol. 425:944-957(2013) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 611-741.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

ACFQ01000009 Genomic DNA. Translation: EEN99657.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3O44	X-ray	2.88	A/B/C/D/E/F/G/H/I/J/K/L/M/N	149-741	[»]
4GX7	X-ray	2.85	A/B/C/D/E/F	611-741	[»]

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-59627N.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

EEN99657; EEN99657; VCG_000884.

PATRIC

29690304. VBIVibCho6176_0900.

Family and domain databases

Gene3D

2.70.240.10. 1 hit.

InterPro

IPR022220. Hemolysin_N.
IPR001340. Leukocidin/haemolysin.
IPR000772. Ricin_B_lectin.
[Graphical view]

Pfam

PF12563. Hemolysin_N. 1 hit.
PF07968. Leukocidin. 1 hit.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view]

SMART

SM00458. RICIN. 1 hit.
[Graphical view]

SUPFAM

SSF50370. RicinB_like. 1 hit.

PROSITE

PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

C2C744_VIBCL

Accession

Primary (citable) accession number: C2C744

Entry history

Integrated into UniProtKB/TrEMBL:	June 16, 2009
Last sequence update:	June 16, 2009
Last modified:	May 1, 2013
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)