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C2C744

- C2C744_VIBCL

UniProt

C2C744 - C2C744_VIBCL

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Protein
Submitted name: Cytolysin and hemolysin HlyA Pore-forming toxin
Gene
VCG_000884
Organism
Vibrio cholerae 12129(1)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. cytolysis in other organism Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Cytolysin and hemolysin HlyA Pore-forming toxinImported
Gene namesi
ORF Names:VCG_000884Imported
OrganismiVibrio cholerae 12129(1)Imported
Taxonomic identifieri592313 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

DIPiDIP-59627N.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3O44X-ray2.88A/B/C/D/E/F/G/H/I/J/K/L/M/N149-741[»]
4GX7X-ray2.85A/B/C/D/E/F611-741[»]

Family & Domainsi

Family and domain databases

Gene3Di2.70.240.10. 1 hit.
InterProiIPR022220. Hemolysin_N.
IPR016183. Leukocidin/porin.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF12563. Hemolysin_N. 1 hit.
PF07968. Leukocidin. 1 hit.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view]
SMARTiSM00458. RICIN. 1 hit.
[Graphical view]
SUPFAMiSSF50370. SSF50370. 1 hit.
SSF56959. SSF56959. 1 hit.
PROSITEiPS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C2C744-1 [UniParc]FASTAAdd to Basket

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MPKLNRCAIA IFTILSAISS PTLLANINEP SGEAADIISQ VADSHAIKYY    50
NAADWQAEDN ALPSLAELRD LVINQQKRVL VDFSQISDAE GQAEMQAQFR 100
KAYGVGFANQ FIVITEHKGE LLFTPFDQAQ EVDPQLLEAP RTARLLARSG 150
FASPAPANSE TNTLPHVAFY ISVNRAISDE ECTFNNSWLW KNEKGSRPFC 200
KDANISLIYR VNLERSLQYG IVGSATPDAK IVRISLDDDS TGAGIHLNDQ 250
LGYRQFGASY TTLDAYFREW STDAIAQDYR FVFNASNNKA QILKTFPVDN 300
INEKFERKEV SGFELGVTGG VEVSGDGPKA KLEARASYTQ SRWLTYNTQD 350
YRIERNAKNA QAVSFTWNRQ QYATAESLLN RSTDALWVNT YPVDVNRISP 400
LSYASFVPKM DVIYKASATE TGSTDFIIDS SVNIRPIYNG AYKHYYVVGA 450
HQSYHGFEDT PRRRITKSAS FTVDWDHPVF TGGRPVNLQL ASFNNRCIQV 500
DAQGRLTANM CDSQQSAQSF IYDQLGRYVS ASNTKLCLDG AALDALQPCN 550
QNLTQRWEWR KGTDELTNVY SGESLGHDKQ TGELGLYASS NDAVSLRTIT 600
AYTDVFNAQE SSPILGYTQG KMNQQRVGQD HRLYVRAGAA IDALGSASDL 650
LVGGNGGSLS SVDLSGVKSI TATSGDFQYG GQQLVALTFT YQDGRQQTVG 700
SKAYVTNAHE DRFDLPDAAK ITQLKIWADD WLVKGVQFDL N 741
Length:741
Mass (Da):81,991
Last modified:June 16, 2009 - v1
Checksum:i6013B78B64F4133F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACFQ01000009 Genomic DNA. Translation: EEN99657.1.

Genome annotation databases

EnsemblBacteriaiEEN99657; EEN99657; VCG_000884.
PATRICi29690304. VBIVibCho6176_0900.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACFQ01000009 Genomic DNA. Translation: EEN99657.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3O44 X-ray 2.88 A/B/C/D/E/F/G/H/I/J/K/L/M/N 149-741 [» ]
4GX7 X-ray 2.85 A/B/C/D/E/F 611-741 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-59627N.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EEN99657 ; EEN99657 ; VCG_000884 .
PATRICi 29690304. VBIVibCho6176_0900.

Family and domain databases

Gene3Di 2.70.240.10. 1 hit.
InterProi IPR022220. Hemolysin_N.
IPR016183. Leukocidin/porin.
IPR000772. Ricin_B_lectin.
[Graphical view ]
Pfami PF12563. Hemolysin_N. 1 hit.
PF07968. Leukocidin. 1 hit.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view ]
SMARTi SM00458. RICIN. 1 hit.
[Graphical view ]
SUPFAMi SSF50370. SSF50370. 1 hit.
SSF56959. SSF56959. 1 hit.
PROSITEi PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome Assortment, Not Serogroup, Defines Vibrio cholerae Pandemic Strains."
    Los Alamos National Laboratory (LANL), National Microbial Pathogen Data Resource (NMPDR)
    Munk A.C., Tapia R., Green L., Rogers Y., Detter J.C., Bruce D., Brettin T.S., Colwell R.R., Huq A., Grim C.J., Hasan N.A., Bartels D., Vonstein V.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 12129Imported.
  2. "Crystal structure of the Vibrio cholerae cytolysin heptamer reveals common features among disparate pore-forming toxins."
    De S., Olson R.
    Proc. Natl. Acad. Sci. U.S.A. 108:7385-7390(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.88 ANGSTROMS) OF 149-741.
  3. "Vibrio cholerae cytolysin recognizes the heptasaccharide core of complex N-glycans with nanomolar affinity."
    Levan S., De S., Olson R.
    J. Mol. Biol. 425:944-957(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 611-741.

Entry informationi

Entry nameiC2C744_VIBCL
AccessioniPrimary (citable) accession number: C2C744
Entry historyi
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: September 3, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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