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C2C744 (C2C744_VIBCL) Unreviewed, UniProtKB/TrEMBL

Last modified December 11, 2013. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
ORF Names:VCG_000884 EMBL EEN99657.1
OrganismVibrio cholerae 12129(1) EMBL EEN99657.1
Taxonomic identifier592313 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length741 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Ontologies

Keywords
   Technical term3D-structure PDB 3O44 PDB 4GX7
Gene Ontology (GO)
   Biological_processcytolysis in other organism

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
C2C744 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: 6013B78B64F4133F

FASTA74181,991
        10         20         30         40         50         60 
MPKLNRCAIA IFTILSAISS PTLLANINEP SGEAADIISQ VADSHAIKYY NAADWQAEDN 

        70         80         90        100        110        120 
ALPSLAELRD LVINQQKRVL VDFSQISDAE GQAEMQAQFR KAYGVGFANQ FIVITEHKGE 

       130        140        150        160        170        180 
LLFTPFDQAQ EVDPQLLEAP RTARLLARSG FASPAPANSE TNTLPHVAFY ISVNRAISDE 

       190        200        210        220        230        240 
ECTFNNSWLW KNEKGSRPFC KDANISLIYR VNLERSLQYG IVGSATPDAK IVRISLDDDS 

       250        260        270        280        290        300 
TGAGIHLNDQ LGYRQFGASY TTLDAYFREW STDAIAQDYR FVFNASNNKA QILKTFPVDN 

       310        320        330        340        350        360 
INEKFERKEV SGFELGVTGG VEVSGDGPKA KLEARASYTQ SRWLTYNTQD YRIERNAKNA 

       370        380        390        400        410        420 
QAVSFTWNRQ QYATAESLLN RSTDALWVNT YPVDVNRISP LSYASFVPKM DVIYKASATE 

       430        440        450        460        470        480 
TGSTDFIIDS SVNIRPIYNG AYKHYYVVGA HQSYHGFEDT PRRRITKSAS FTVDWDHPVF 

       490        500        510        520        530        540 
TGGRPVNLQL ASFNNRCIQV DAQGRLTANM CDSQQSAQSF IYDQLGRYVS ASNTKLCLDG 

       550        560        570        580        590        600 
AALDALQPCN QNLTQRWEWR KGTDELTNVY SGESLGHDKQ TGELGLYASS NDAVSLRTIT 

       610        620        630        640        650        660 
AYTDVFNAQE SSPILGYTQG KMNQQRVGQD HRLYVRAGAA IDALGSASDL LVGGNGGSLS 

       670        680        690        700        710        720 
SVDLSGVKSI TATSGDFQYG GQQLVALTFT YQDGRQQTVG SKAYVTNAHE DRFDLPDAAK 

       730        740 
ITQLKIWADD WLVKGVQFDL N 

« Hide

References

[1]"Genome Assortment, Not Serogroup, Defines Vibrio cholerae Pandemic Strains."
Los Alamos National Laboratory (LANL), National Microbial Pathogen Data Resource (NMPDR)
Munk A.C., Tapia R., Green L., Rogers Y., Detter J.C., Bruce D., Brettin T.S., Colwell R.R., Huq A., Grim C.J., Hasan N.A., Bartels D., Vonstein V.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 12129 EMBL EEN99657.1.
[2]"Crystal structure of the Vibrio cholerae cytolysin heptamer reveals common features among disparate pore-forming toxins."
De S., Olson R.
Proc. Natl. Acad. Sci. U.S.A. 108:7385-7390(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.88 ANGSTROMS) OF 149-741.
[3]"Vibrio cholerae cytolysin recognizes the heptasaccharide core of complex N-glycans with nanomolar affinity."
Levan S., De S., Olson R.
J. Mol. Biol. 425:944-957(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 611-741.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
ACFQ01000009 Genomic DNA. Translation: EEN99657.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3O44X-ray2.88A/B/C/D/E/F/G/H/I/J/K/L/M/N149-741[»]
4GX7X-ray2.85A/B/C/D/E/F611-741[»]
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-59627N.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEEN99657; EEN99657; VCG_000884.
PATRIC29690304. VBIVibCho6176_0900.

Family and domain databases

Gene3D2.70.240.10. 1 hit.
InterProIPR022220. Hemolysin_N.
IPR001340. Leukocidin/haemolysin_toxin.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamPF12563. Hemolysin_N. 1 hit.
PF07968. Leukocidin. 1 hit.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view]
SMARTSM00458. RICIN. 1 hit.
[Graphical view]
SUPFAMSSF50370. SSF50370. 1 hit.
PROSITEPS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC2C744_VIBCL
AccessionPrimary (citable) accession number: C2C744
Entry history
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: December 11, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)