Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

C2C744

- C2C744_VIBCL

UniProt

C2C744 - C2C744_VIBCL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

Cytolysin and hemolysin HlyA Pore-forming toxin

Gene

VCG_000884

Organism
Vibrio cholerae 12129(1)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. cytolysis in other organism Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Cytolysin and hemolysin HlyA Pore-forming toxinImported
Gene namesi
ORF Names:VCG_000884Imported
OrganismiVibrio cholerae 12129(1)Imported
Taxonomic identifieri592313 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

DIPiDIP-59627N.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3O44X-ray2.88A/B/C/D/E/F/G/H/I/J/K/L/M/N149-741[»]
4GX7X-ray2.85A/B/C/D/E/F611-741[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di2.70.240.10. 1 hit.
InterProiIPR022220. Hemolysin_N.
IPR016183. Leukocidin/porin.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF12563. Hemolysin_N. 1 hit.
PF07968. Leukocidin. 1 hit.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view]
SMARTiSM00458. RICIN. 1 hit.
[Graphical view]
SUPFAMiSSF50370. SSF50370. 1 hit.
SSF56959. SSF56959. 1 hit.
PROSITEiPS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C2C744-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPKLNRCAIA IFTILSAISS PTLLANINEP SGEAADIISQ VADSHAIKYY
60 70 80 90 100
NAADWQAEDN ALPSLAELRD LVINQQKRVL VDFSQISDAE GQAEMQAQFR
110 120 130 140 150
KAYGVGFANQ FIVITEHKGE LLFTPFDQAQ EVDPQLLEAP RTARLLARSG
160 170 180 190 200
FASPAPANSE TNTLPHVAFY ISVNRAISDE ECTFNNSWLW KNEKGSRPFC
210 220 230 240 250
KDANISLIYR VNLERSLQYG IVGSATPDAK IVRISLDDDS TGAGIHLNDQ
260 270 280 290 300
LGYRQFGASY TTLDAYFREW STDAIAQDYR FVFNASNNKA QILKTFPVDN
310 320 330 340 350
INEKFERKEV SGFELGVTGG VEVSGDGPKA KLEARASYTQ SRWLTYNTQD
360 370 380 390 400
YRIERNAKNA QAVSFTWNRQ QYATAESLLN RSTDALWVNT YPVDVNRISP
410 420 430 440 450
LSYASFVPKM DVIYKASATE TGSTDFIIDS SVNIRPIYNG AYKHYYVVGA
460 470 480 490 500
HQSYHGFEDT PRRRITKSAS FTVDWDHPVF TGGRPVNLQL ASFNNRCIQV
510 520 530 540 550
DAQGRLTANM CDSQQSAQSF IYDQLGRYVS ASNTKLCLDG AALDALQPCN
560 570 580 590 600
QNLTQRWEWR KGTDELTNVY SGESLGHDKQ TGELGLYASS NDAVSLRTIT
610 620 630 640 650
AYTDVFNAQE SSPILGYTQG KMNQQRVGQD HRLYVRAGAA IDALGSASDL
660 670 680 690 700
LVGGNGGSLS SVDLSGVKSI TATSGDFQYG GQQLVALTFT YQDGRQQTVG
710 720 730 740
SKAYVTNAHE DRFDLPDAAK ITQLKIWADD WLVKGVQFDL N
Length:741
Mass (Da):81,991
Last modified:June 16, 2009 - v1
Checksum:i6013B78B64F4133F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACFQ01000009 Genomic DNA. Translation: EEN99657.1.

Genome annotation databases

EnsemblBacteriaiEEN99657; EEN99657; VCG_000884.
PATRICi29690304. VBIVibCho6176_0900.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
ACFQ01000009 Genomic DNA. Translation: EEN99657.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3O44 X-ray 2.88 A/B/C/D/E/F/G/H/I/J/K/L/M/N 149-741 [» ]
4GX7 X-ray 2.85 A/B/C/D/E/F 611-741 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-59627N.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EEN99657 ; EEN99657 ; VCG_000884 .
PATRICi 29690304. VBIVibCho6176_0900.

Family and domain databases

Gene3Di 2.70.240.10. 1 hit.
InterProi IPR022220. Hemolysin_N.
IPR016183. Leukocidin/porin.
IPR000772. Ricin_B_lectin.
[Graphical view ]
Pfami PF12563. Hemolysin_N. 1 hit.
PF07968. Leukocidin. 1 hit.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view ]
SMARTi SM00458. RICIN. 1 hit.
[Graphical view ]
SUPFAMi SSF50370. SSF50370. 1 hit.
SSF56959. SSF56959. 1 hit.
PROSITEi PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome Assortment, Not Serogroup, Defines Vibrio cholerae Pandemic Strains."
    Los Alamos National Laboratory (LANL), National Microbial Pathogen Data Resource (NMPDR)
    Munk A.C., Tapia R., Green L., Rogers Y., Detter J.C., Bruce D., Brettin T.S., Colwell R.R., Huq A., Grim C.J., Hasan N.A., Bartels D., Vonstein V.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 12129Imported.
  2. "Crystal structure of the Vibrio cholerae cytolysin heptamer reveals common features among disparate pore-forming toxins."
    De S., Olson R.
    Proc. Natl. Acad. Sci. U.S.A. 108:7385-7390(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.88 ANGSTROMS) OF 149-741.
  3. "Vibrio cholerae cytolysin recognizes the heptasaccharide core of complex N-glycans with nanomolar affinity."
    Levan S., De S., Olson R.
    J. Mol. Biol. 425:944-957(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 611-741.

Entry informationi

Entry nameiC2C744_VIBCL
AccessioniPrimary (citable) accession number: C2C744
Entry historyi
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: October 29, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3