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Protein

Small toxic protein IbsE

Gene

ibsE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be a toxic protein; overexpression causes cessation of growth.1 Publication

Miscellaneous

Part of the SIBe repeat region, encoded on the opposite strand from the sibE RNA.

GO - Biological processi

  • programmed cell death Source: EcoCyc

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-2855.

Names & Taxonomyi

Protein namesi
Recommended name:
Small toxic protein IbsE
Gene namesi
Name:ibsE
Ordered Locus Names:b4666, JW3023.2
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14471. ibsE.

Pathology & Biotechi

Disruption phenotypei

None seen. An isbE overproducing strain cannot be made in the absence of the sibE gene.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003864241 – 19Small toxic protein IbsEAdd BLAST19

Proteomic databases

PaxDbiC1P617.
PRIDEiC1P617.

Expressioni

Inductioni

The sibE sRNA probably represses expression of ibsE mRNA, either by destabilizing the transcript and/or preventing its translation. A type I toxin antitoxin (TA) system, where expression of the proteinaceous toxin is controlled by an antisense sRNA.

Interactioni

Protein-protein interaction databases

STRINGi511145.b4666.

Family & Domainsi

Sequence similaritiesi

Belongs to the toxic protein ibs family.Curated

Phylogenomic databases

KOiK19153.

Family and domain databases

InterProiView protein in InterPro
IPR025881. Toxin_Ibs.
PfamiView protein in Pfam
PF13956. Ibs_toxin. 1 hit.

Sequencei

Sequence statusi: Complete.

C1P617-1 [UniParc]FASTAAdd to basket

« Hide

        10 
MMKLVIILVV LLLLSFPTY
Length:19
Mass (Da):2,207
Last modified:May 26, 2009 - v1
Checksum:i792BA438C3C048F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: ACO60009.1.
AP009048 Genomic DNA. No translation available.
RefSeqiWP_010723221.1. NZ_LN832404.1.
YP_002791257.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiACO60009; ACO60009; b4666.
GeneIDi7751629.
KEGGieco:b4666.

Similar proteinsi

Entry informationi

Entry nameiIBSE_ECOLI
AccessioniPrimary (citable) accession number: C1P617
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: May 26, 2009
Last modified: March 15, 2017
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families