C1P617 (IBSE_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Small toxic protein ibsE

Gene names

Name:	ibsE
Ordered Locus Names:	b4666, JW3023.2

Organism

Escherichia coli (strain K12)

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	19 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be a toxic protein; overexpression causes cessation of growth. Ref.3
Induction	The sibE sRNA probably represses expression of ibsE mRNA, either by destabilizing the transcript and/or preventing its translation. A type I toxin antitoxin (TA) system, where expression of the proteinaceous toxin is controlled by an antisense sRNA.
Disruption phenotype	None seen. An isbE overproducing strain cannot be made in the absence of the sibE gene. Ref.3
Miscellaneous	Part of the SIBe repeat region, encoded on the opposite strand from the sibE RNA.
Sequence similarities	Belongs to the toxic protein ibs family.

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	programmed cell death Inferred from mutant phenotype Ref.3. Source: EcoCyc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 19	19	Small toxic protein ibsE		PRO_0000386424

Sequences

	Sequence		Length	Mass (Da)
	C1P617 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 792BA438C3C048F7	FASTA	19	2,207
	10 MMKLVIILVV LLLLSFPTY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]	"Repression of small toxic protein synthesis by the Sib and OhsC small RNAs." Fozo E.M., Kawano M., Fontaine F., Kaya Y., Mendieta K.S., Jones K.L., Ocampo A., Rudd K.E., Storz G. Mol. Microbiol. 70:1076-1093(2008) [PubMed: 18710431] [Abstract] Cited for: IDENTIFICATION, FUNCTION, OVEREXPRESSION, DISRUPTION PHENOTYPE. Strain: K12 / MG1655 / ATCC 47076.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00096 Genomic DNA. Translation: ACO60009.1. AP009048 Genomic DNA. No translation available.
RefSeq	YP_002791257.1. NC_000913.2.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000103175; EBESCP00000141853; EBESCG00000102195. EBESCT00000151767; EBESCP00000141871; EBESCG00000150827.
GeneID	7751629.
GenomeReviews	Gene locus JW3023.2 in contig AP009048_GR. Gene locus b4666 in contig U00096_GR.
KEGG	eco:b4666.
Organism-specific databases
EcoGene	EG14471. ibsE.
Enzyme and pathway databases
BioCyc	EcoCyc:MONOMER0-2855.
Gene expression databases
Genevestigator	C1P617.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

IBSE_ECOLI

Accession

Primary (citable) accession number: C1P617

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 13, 2009
Last sequence update:	May 26, 2009
Last modified:	December 14, 2011
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program