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C1NCP0 (C1NCP0_9ESCH) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
S-ribosylhomocysteine lyase HAMAP MF_00091
EC=4.4.1.21 HAMAP MF_00091
Alternative name(s):
AI-2 synthesis protein HAMAP MF_00091
Autoinducer-2 production protein LuxS HAMAP MF_00091
Gene names
Name:luxS HAMAP MF_00091
ORF Names:ESCG_00062 EMBL EEH71375.1
OrganismEscherichia sp. 1_1_43 EMBL EEH71375.1
Taxonomic identifier457400 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length171 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) By similarity. HAMAP MF_00091 SAAS SAAS003815

Catalytic activity

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione. HAMAP MF_00091 SAAS SAAS003815

Cofactor

Binds 1 iron ion per subunit By similarity. HAMAP MF_00091 SAAS SAAS003815

Subunit structure

Homodimer By similarity. HAMAP MF_00091 SAAS SAAS003815

Sequence similarities

Belongs to the LuxS family. HAMAP MF_00091

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding541Iron By similarity HAMAP MF_00091
Metal binding581Iron By similarity HAMAP MF_00091
Metal binding1281Iron By similarity HAMAP MF_00091

Sequences

Sequence LengthMass (Da)Tools
C1NCP0 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: 131F57F1866DA105

FASTA17119,416
        10         20         30         40         50         60 
MPLLDSFTVD HTRMEAPAVR VAKTMNTPHG DAITVFDLRF CVPNKEVMPE RGIHTLEHLF 

        70         80         90        100        110        120 
AGFMRNHLNG NGVEIIDISP MGCRTGFYMS LIGTPDEQRV ADAWKAAMED VLKVQDQNQI 

       130        140        150        160        170 
PELNVYQCGT YQMHSLQEAQ DIARSILERD VRINSNEELA LPKEKLQELH I

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		GG665830 Genomic DNA. Translation: EEH71375.1.

3D structure databases

ProteinModelPortalC1NCP0.
SMRC1NCP0. Positions 3-161.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

PATRIC31132728. VBIEscSp5885_0670.

Family and domain databases

HAMAPMF_00091. LuxS.
[Tree]
InterProIPR011249. Metalloenz_metal-bd.
IPR003815. S-ribosylhomocysteinase.
[Graphical view]
Gene3DG3DSA:3.30.1360.80. S-ribosylhomocysteinase. 1 hit.
PfamPF02664. LuxS. 1 hit.
[Graphical view]
PIRSFPIRSF006160. AI2. 1 hit.
PRINTSPR01487. LUXSPROTEIN.
ProDomPD013172. S-ribosylhomocysteinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF63411. Metalloenz_metal-bd. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC1NCP0_9ESCH
AccessionPrimary (citable) accession number: C1NCP0
Entry history
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: December 14, 2011
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info