Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Cathepsin D (Lysosomal aspartyl protease)

Gene

ctsd

Organism
Schistosoma japonicum (Blood fluke)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei84PROSITE-ProRule annotation1
Active sitei270PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl proteasePROSITE-ProRule annotation, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.009.

Names & Taxonomyi

Protein namesi
Submitted name:
Cathepsin D (Lysosomal aspartyl protease)Imported (EC:3.4.23.5Imported)
Gene namesi
Name:ctsdImported
OrganismiSchistosoma japonicum (Blood fluke)Imported
Taxonomic identifieri6182 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 380Peptidase A1InterPro annotationAdd BLAST315

Sequence similaritiesi

Belongs to the peptidase A1 family.PROSITE-ProRule annotationSAAS annotation

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiView protein in InterPro
IPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom_sf.
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiView protein in Pfam
PF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiView protein in PROSITE
PS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.

Sequencei

Sequence statusi: Complete.

C1LC77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHLLLLLHL VSSEVVRVPL YPLKSARRSL IEFETSLENV QKVWFSRFSN
60 70 80 90 100
VEPRPEYLKN YLDAQYYGDI TVGTPPQTFS VVFDTGSSNL WVPSKHCSYF
110 120 130 140 150
DIACLLHRKY DSSKSTTYVP NGTDFSIRYG TGSLSGFLST DSLQLGSLGV
160 170 180 190 200
KGQTFGEATK QPGLVFVMAK FDGILGMAYP SLAVGGVTPV FVNMIKQGVV
210 220 230 240 250
DSPVFSFYLS RNITNVLGGE LMIGGIDDKY YTGEINYVNL TEKSYWLFKM
260 270 280 290 300
DNLTISDLSI CTDGCQAIAD TGTSMIAGPT DEVKQINQKL GATHLPGGIY
310 320 330 340 350
TVSCDVINNL PSIDFVINGK HMTLEPTDYI MKVSKLGSEI CLTGFIGMDL
360 370 380 390 400
PRKKLWILGD VFIGKFYTIF DMGKNRVGFA KAVKPDSSYH HTKVYSPMLR
410 420
LFPAQSIPKV APKSPNGVFA FSKLLHDAN
Length:429
Mass (Da):47,368
Last modified:October 3, 2012 - v1
Checksum:i09AC7F743CCBC4DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN316574 mRNA. Translation: CAX72305.1.

Similar proteinsi

Entry informationi

Entry nameiC1LC77_SCHJA
AccessioniPrimary (citable) accession number: C1LC77
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: November 22, 2017
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation