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Protein

Exodeoxyribonuclease 7 large subunit

Gene

xseA

Organism
Listeria monocytogenes serotype 4b (strain CLIP80459)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.UniRule annotation

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 7 large subunitUniRule annotation (EC:3.1.11.6UniRule annotation)
Alternative name(s):
Exodeoxyribonuclease VII large subunitUniRule annotation
Short name:
Exonuclease VII large subunitUniRule annotation
Gene namesi
Name:xseAUniRule annotation
Ordered Locus Names:Lm4b_01369
OrganismiListeria monocytogenes serotype 4b (strain CLIP80459)
Taxonomic identifieri568819 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002056781 – 450Exodeoxyribonuclease 7 large subunitAdd BLAST450

Interactioni

Subunit structurei

Heterooligomer composed of large and small subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC1L2R7.
SMRiC1L2R7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the XseA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229265.
KOiK03601.
OMAiFRQNATR.

Family and domain databases

CDDicd04489. ExoVII_LU_OBF. 1 hit.
HAMAPiMF_00378. Exonuc_7_L. 1 hit.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 1 hit.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.

Sequencei

Sequence statusi: Complete.

C1L2R7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQDKYLTVA AITKYIEKKF EVDPYMKQVF VRGEISNLKQ PASGHLYFTV
60 70 80 90 100
KDEFAMLRSV MFHKAVQKIG FVPEDGMNVL ITGRIGVFTK AGRYQFYAEH
110 120 130 140 150
MEPDGVGALY IQLEQLKSQL EKEGLFAETH KKVLPSFPSK VAVVTSKTGA
160 170 180 190 200
AVRDILTTIH RRMPSVEVIV YPTIVQGEKA AQKIVENIGK INQRNDIDVM
210 220 230 240 250
IIGRGGGSLE ELWAFNEEPV VRAVYDSDVP VISAVGHETD FALSDFSADV
260 270 280 290 300
RAATPTAAAE LAVPDYRDLE ERLAERKYRL LAVTRQALER KERSLEQLKQ
310 320 330 340 350
HLILNGPKHQ LEQQMERTDY FSERLNNAFS KQIFVKQTVF DRLNDRLHYY
360 370 380 390 400
HPNKEIELQK EQMALRLQAL EKAMKQLLKD KQQSFFRQID ALEHLSPLSL
410 420 430 440 450
LKRGFGVTYK ENMLVKSVQE LEVGDNIQVK MQGGQIEALI TAKEEDISGN
Length:450
Mass (Da):51,291
Last modified:May 26, 2009 - v1
Checksum:i4F57B22496E0ADE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM242711 Genomic DNA. Translation: CAS05133.1.
RefSeqiWP_003727476.1. NC_012488.1.

Genome annotation databases

EnsemblBacteriaiCAS05133; CAS05133; Lm4b_01369.
KEGGilmc:Lm4b_01369.
PATRICi20305909. VBILisMon88360_1381.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM242711 Genomic DNA. Translation: CAS05133.1.
RefSeqiWP_003727476.1. NC_012488.1.

3D structure databases

ProteinModelPortaliC1L2R7.
SMRiC1L2R7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAS05133; CAS05133; Lm4b_01369.
KEGGilmc:Lm4b_01369.
PATRICi20305909. VBILisMon88360_1381.

Phylogenomic databases

HOGENOMiHOG000229265.
KOiK03601.
OMAiFRQNATR.

Family and domain databases

CDDicd04489. ExoVII_LU_OBF. 1 hit.
HAMAPiMF_00378. Exonuc_7_L. 1 hit.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 1 hit.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEX7L_LISMC
AccessioniPrimary (citable) accession number: C1L2R7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: November 2, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.