Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Listeria monocytogenes serotype 4b (strain CLIP80459)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:Lm4b_01358
OrganismiListeria monocytogenes serotype 4b (strain CLIP80459)
Taxonomic identifieri568819 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000002203 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 488488Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000212672Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei274 – 2741N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi634178.Lm4b_01358.

Structurei

3D structure databases

ProteinModelPortaliC1L2Q6.
SMRiC1L2Q6. Positions 6-486.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000239368.
KOiK00283.
OMAiMHINLHK.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

C1L2Q6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLEETMPLV FERSIPGRIG FSLPESDVPE TKASDYFEQA YIRSVPADLP
60 70 80 90 100
ELSELEIMRH YTNLSNHNFG VDSGFYPLGS CTMKYNPKIN EKVARFPGFA
110 120 130 140 150
NIHPNQPESS VQGALELLYD LQTSLVEITG MDEVTLQPAA GAHGEWTGLM
160 170 180 190 200
LIRAFHEKNG DTKRTKVIIP DSAHGTNPAS AAVAGFDVVT VKSNEKGLVD
210 220 230 240 250
VADLKKVVGE DTAALMLTNP NTLGLFEKDI VEMAEIVHEA GGKLYYDGAN
260 270 280 290 300
LNAIMAKVRP GDMGFDVVHL NLHKTFTGPH GGGGPGSGPI GVKKELIPFL
310 320 330 340 350
PTPVLTKKEE GYSFDYNYPD SIGRVKPYYG NFGINVRAYT YIRTMGPDGL
360 370 380 390 400
KLVTEYAVLN ANYMMRKLQE AYDLPFDQVC KHEFVLSGNR QKKLGVRTVD
410 420 430 440 450
IAKRLLDHNF HPPTVYFPLI VGEAIMIEPT ETESKETLDS FIDTMLKIAK
460 470 480
EAEENPEIVQ EAPHSTYVKR LDETRAARKP ILRYQKEV
Length:488
Mass (Da):54,186
Last modified:May 25, 2009 - v1
Checksum:iB1F2454EADDE212B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM242711 Genomic DNA. Translation: CAS05122.1.
RefSeqiYP_002758058.1. NC_012488.1.

Genome annotation databases

EnsemblBacteriaiCAS05122; CAS05122; Lm4b_01358.
KEGGilmc:Lm4b_01358.
PATRICi20305887. VBILisMon88360_1370.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM242711 Genomic DNA. Translation: CAS05122.1.
RefSeqiYP_002758058.1. NC_012488.1.

3D structure databases

ProteinModelPortaliC1L2Q6.
SMRiC1L2Q6. Positions 6-486.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi634178.Lm4b_01358.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAS05122; CAS05122; Lm4b_01358.
KEGGilmc:Lm4b_01358.
PATRICi20305887. VBILisMon88360_1370.

Phylogenomic databases

HOGENOMiHOG000239368.
KOiK00283.
OMAiMHINLHK.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CLIP80459.

Entry informationi

Entry nameiGCSPB_LISMC
AccessioniPrimary (citable) accession number: C1L2Q6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2009
Last sequence update: May 25, 2009
Last modified: March 31, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.