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C1L2Q5

- GCSPA_LISMC

UniProt

C1L2Q5 - GCSPA_LISMC

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Listeria monocytogenes serotype 4b (strain CLIP80459)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (26 May 2009)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro
    2. nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciLMON568819:GJF9-2017-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 1UniRule annotation
    Glycine decarboxylase subunit 1UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
    Gene namesi
    Name:gcvPAUniRule annotation
    Ordered Locus Names:Lm4b_01357
    OrganismiListeria monocytogenes serotype 4b (strain CLIP80459)
    Taxonomic identifieri568819 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
    ProteomesiUP000002203: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 448448Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000212663Add
    BLAST

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi634178.Lm4b_01357.

    Structurei

    3D structure databases

    ProteinModelPortaliC1L2Q5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000132025.
    KOiK00282.
    OMAiRLVGQTE.
    OrthoDBiEOG6XWV3B.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00712. GcvPA.
    InterProiIPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006815. GcvPA. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C1L2Q5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKHRYLPMT EQDEKEMLDV IGVKSIDDLF QDIPEKIRFK RDYDLKPAKS    50
    EPALLRELSQ LASKNANTTE YASFLGAGVY SHYIPTVVDH VISRSEFYTA 100
    YTPYQPEISQ GELQAIFEFQ TMIAELTGMD LANSSMYDGG TALAEAAMLA 150
    SGHTKRKKIL ISGAVHPESS NVLKTYATGQ HIEVEVIPEL DGKTDIEALK 200
    KALSDDIAGF VVQYPNFYGQ VEPLAELEKL VHENNSLLLV SSNPLSLGLL 250
    TPPGEFGADI VVGDSQVFGI PESFGGPHCG FFAVTNKLMR KVPGRLVGET 300
    VDENGKRGYV LTLQAREQHI RRDKATSNIC SNQALNALAS SVAMATLGKT 350
    GLVEMAKQNL DKSHYAKQKF REKGFEVLFS DGFFNEFVVK LSKPIKEVNE 400
    SLLDEGIIGG YDLGFYEEKY ENHMLVAVTE MRTKEEIDAF VASLEGAK 448
    Length:448
    Mass (Da):49,499
    Last modified:May 26, 2009 - v1
    Checksum:i34631D402D289956
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM242711 Genomic DNA. Translation: CAS05121.1.
    RefSeqiYP_002758057.1. NC_012488.1.

    Genome annotation databases

    EnsemblBacteriaiCAS05121; CAS05121; Lm4b_01357.
    GeneIDi7704391.
    KEGGilmc:Lm4b_01357.
    PATRICi20305885. VBILisMon88360_1369.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM242711 Genomic DNA. Translation: CAS05121.1 .
    RefSeqi YP_002758057.1. NC_012488.1.

    3D structure databases

    ProteinModelPortali C1L2Q5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 634178.Lm4b_01357.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAS05121 ; CAS05121 ; Lm4b_01357 .
    GeneIDi 7704391.
    KEGGi lmc:Lm4b_01357.
    PATRICi 20305885. VBILisMon88360_1369.

    Phylogenomic databases

    HOGENOMi HOG000132025.
    KOi K00282.
    OMAi RLVGQTE.
    OrthoDBi EOG6XWV3B.

    Enzyme and pathway databases

    BioCyci LMON568819:GJF9-2017-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00712. GcvPA.
    InterProi IPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006815. GcvPA. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CLIP80459.

    Entry informationi

    Entry nameiGCSPA_LISMC
    AccessioniPrimary (citable) accession number: C1L2Q5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3