C1L2Q4 (GCST_LISMC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	Lm4b_01356

Organism

Listeria monocytogenes serotype 4b (strain Clip81459) [Complete proteome] [HAMAP]

Taxonomic identifier

568819 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Aminomethyltransferase HAMAP MF_00259		PRO_1000204640

Sequences

	Sequence		Length	Mass (Da)
	C1L2Q4 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 5812C4E98C1EE7D1	FASTA	362	39,564
	10 20 30 40 50 60 MTELLKTPIH PLYAKYGAKT IDFGGWDLPV QFAGIKAEHE AVRTDAGLFD VSHMGEILVK 70 80 90 100 110 120 GPDSTSYLQY LLTNDIEKIK IGKAQYNIMC YETGGTVDDL VVYKKSETEY ILVVNAANTD 130 140 150 160 170 180 KDFEWMVKNI RGDVSVTNVS SEYGQLALQG PNAEKILAKL TDVDLSSISF FGFVEDADVA 190 200 210 220 230 240 GVKTIISRSG YTGEDGFEIY MPSADAGKVF EAILAEGVAP IGLGARDTLR LEAVLALYGQ 250 260 270 280 290 300 ELSKDITPLE AGLNFAVKLK KEADFIGKEA LIKQKEVGLN RKLVGIELIE RGIPRHDYPV 310 320 330 340 350 360 FLNEEEIGIV TSGTQSPTLG TNIGLALIDT AYTEIGQEVE VGIRNKKVKA KIVPTPFYKR AK

References

[1]	"Complete genome sequence of Listeria monocytogenes serotype 4b strain Clip81459." Rusniok C. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Clip81459.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM242711 Genomic DNA. Translation: CAS05120.1.
RefSeq	YP_002758056.1. NC_012488.1.
3D structure databases
ProteinModelPortal	C1L2Q4.
ModBase	Search...
Protein-protein interaction databases
STRING	C1L2Q4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7703258.
GenomeReviews	Gene locus Lm4b_01356 in contig FM242711_GR.
KEGG	lmc:Lm4b_01356.
PATRIC	20305883. VBILisMon88360_1368.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	MVKNIRG.
ProtClustDB	PRK00389.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_LISMC

Accession

Primary (citable) accession number: C1L2Q4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	May 26, 2009
Last modified:	January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program