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C1L2N7

- PNP_LISMC

UniProt

C1L2N7 - PNP_LISMC

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Listeria monocytogenes serotype 4b (strain CLIP80459)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi488 – 4881MagnesiumUniRule annotation
Metal bindingi494 – 4941MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Lm4b_01339
OrganismiListeria monocytogenes serotype 4b (strain CLIP80459)
Taxonomic identifieri568819 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000002203: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 723723Polyribonucleotide nucleotidyltransferasePRO_1000215663Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi634178.Lm4b_01339.

Structurei

3D structure databases

ProteinModelPortaliC1L2N7.
SMRiC1L2N7. Positions 620-692.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini555 – 61460KHUniRule annotationAdd
BLAST
Domaini624 – 69269S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C1L2N7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEKQVFSTE WAGKTLSVEV GQLAKQASGA ALIRYGDTVV LTAAVGSKKP
60 70 80 90 100
RPGDFFPLTV NYEEKMYSVG KVPGGFLKRE GRPSDRATLT ARLIDRPIRP
110 120 130 140 150
LFAEGFRNEV QITSTVFSVD QDCSPEMAAM LGSSVALVIS DIPFEGPIAG
160 170 180 190 200
VDVGRIDGKY VINPTIEQAE KSDISLTVAG TYDAINMVEA GAKEVSEEAM
210 220 230 240 250
LEAIMFGHEE IKRLCEFQQQ IIAAVGKEKR EIELFVSDPE LEAEVKAASE
260 270 280 290 300
GKMKAAIKTE EKKAREAAIE DVKEEILESY KAKELENEAE ILSEVAHILE
310 320 330 340 350
MIEKDEMRRL ISQDKIRPDG RKVNEIRPLS SEVGMLPRVH GSGLFTRGQT
360 370 380 390 400
QALSVCTLAP LREHQIIDGL GTEEYKRFMH HYNFPQFSVG ETGPRRAPGR
410 420 430 440 450
REIGHGALGE RALQYVIPSE EEFPYTIRLV SEVLESNGSS SQASICGSTL
460 470 480 490 500
AMLDAGVPIK APVAGIAMGL VKLGDDYTIL SDIQGMEDHF GDMDFKVAGT
510 520 530 540 550
KDGITALQMD IKIDGLSRQI LDEALTQAKE GRLHILEHLT STISAPREEL
560 570 580 590 600
SAYAPKIITL NIKPEKIKDV IGPGGKQINA IIDETGVKID IEQDGTVYIA
610 620 630 640 650
SQDQAMNRKA IAIIEDIVRE VEVGEVYTGK VRRIEKFGAF VELFKGTDGL
660 670 680 690 700
VHISELAHER VGKVEDILKL GDEVTVKVIE VDQQGRVNLS RKALLEKKEQ
710 720
PEGDKKPQAE KKFYPKTKKP ESK
Length:723
Mass (Da):79,542
Last modified:May 26, 2009 - v1
Checksum:i2455C18B879A12C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM242711 Genomic DNA. Translation: CAS05103.1.
RefSeqiYP_002758039.1. NC_012488.1.

Genome annotation databases

EnsemblBacteriaiCAS05103; CAS05103; Lm4b_01339.
GeneIDi7702448.
KEGGilmc:Lm4b_01339.
PATRICi20305849. VBILisMon88360_1351.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM242711 Genomic DNA. Translation: CAS05103.1 .
RefSeqi YP_002758039.1. NC_012488.1.

3D structure databases

ProteinModelPortali C1L2N7.
SMRi C1L2N7. Positions 620-692.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 634178.Lm4b_01339.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAS05103 ; CAS05103 ; Lm4b_01339 .
GeneIDi 7702448.
KEGGi lmc:Lm4b_01339.
PATRICi 20305849. VBILisMon88360_1351.

Phylogenomic databases

HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CLIP80459.

Entry informationi

Entry nameiPNP_LISMC
AccessioniPrimary (citable) accession number: C1L2N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: November 26, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3