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C1L1C4 (C1L1C4_LISMC) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddlA EMBL CAS04639.1
Synonyms:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Lm4b_00871 EMBL CAS04639.1
OrganismListeria monocytogenes serotype 4b (strain CLIP80459) [Complete proteome] [HAMAP] EMBL CAS04639.1
Taxonomic identifier568819 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Protein attributes

Sequence length370 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain144 – 352209ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding177 – 23256ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3061Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3191Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3191Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3211Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
C1L1C4 [UniParc].

Last modified May 26, 2009. Version 1.
Checksum: FC5A5951BA851BDA

FASTA37040,569
        10         20         30         40         50         60 
MKTKLILLYG GKSAEHEVSL QTAFSVINAL DLEKFEAAPI YITNEGEWIQ GPLLSGKLDF 

        70         80         90        100        110        120 
VEQLRFSATD TIKLATTESE KSEGEAISPA VLEADGQETV VFPLLHGPNG EDGTVQGLFE 

       130        140        150        160        170        180 
VLNIPYVGNG VLASSAAMDK IVMKKIFADA GIPQVPAVAV RLIDWKNYQA EMVAEMEEVL 

       190        200        210        220        230        240 
TYPVFVKPAN LGSSVGISKA TNKKELADAM TEAFLYDRRV VVEQGVVARE IEMGVLGNDT 

       250        260        270        280        290        300 
PVCSVPGEIL PEGAVATFYD YKAKYQDNNT ALIIPTEVDP EILEQMKEYA VQAFLGLDAS 

       310        320        330        340        350        360 
GLVRADFFLT EDNQLFLNEV NTMPGFTPYS MYPLLWQETG LPYGALIERL VDLAKERHAA 

       370 
KNALKYKLED 

« Hide

References

[1]"Comparative genomics and transcriptomics of lineages I, II, and III strains of Listeria monocytogenes."
Hain T., Ghai R., Billion A., Kuenne C.T., Steinweg C., Izar B., Mohamed W., Mraheil M., Domann E., Schaffrath S., Karst U., Goesmann A., Oehm S., Puhler A., Merkl R., Vorwerk S., Glaser P., Garrido P. expand/collapse author list , Rusniok C., Buchrieser C., Goebel W., Chakraborty T.
BMC Genomics 13:144-144(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CLIP80459.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FM242711 Genomic DNA. Translation: CAS04639.1.
RefSeqYP_002757580.1. NC_012488.1.

3D structure databases

ProteinModelPortalC1L1C4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING634178.Lm4b_00871.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAS04639; CAS04639; Lm4b_00871.
GeneID7703927.
KEGGlmc:Lm4b_00871.
PATRIC20304875. VBILisMon88360_0871.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011593.
KOK01921.
OMAQIDVIFP.
OrthoDBEOG64BQ73.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC1L1C4_LISMC
AccessionPrimary (citable) accession number: C1L1C4
Entry history
Integrated into UniProtKB/TrEMBL: May 26, 2009
Last sequence update: May 26, 2009
Last modified: June 11, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)