C1KZA1 (IOLC_LISMC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5-dehydro-2-deoxygluconokinase
EC=2.7.1.92

Alternative name(s):
2-deoxy-5-keto-D-gluconate kinase
Short name=DKG kinase

Gene names

Name:	iolC
Ordered Locus Names:	Lm4b_00403

Organism

Listeria monocytogenes serotype 4b (strain CLIP80459) [Complete proteome] [HAMAP]

Taxonomic identifier

568819 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Listeriaceae › Listeria › Listeria monocytogenes

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D-gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP) By similarity. HAMAP-Rule MF_01668
Catalytic activity	ATP + 5-dehydro-2-deoxy-D-gluconate = ADP + 6-phospho-5-dehydro-2-deoxy-D-gluconate. HAMAP-Rule MF_01668
Pathway	Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 5/7. HAMAP-Rule MF_01668
Sequence similarities	Belongs to the carbohydrate kinase PfkB family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	inositol catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	5-dehydro-2-deoxygluconokinase activity Inferred from electronic annotation. Source: HAMAP ATP binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 325	325	5-dehydro-2-deoxygluconokinase HAMAP-Rule MF_01668		PRO_1000215881

Sequences

	Sequence		Length	Mass (Da)
	C1KZA1 [UniParc]. Last modified May 26, 2009. Version 1. Checksum: 88E0913E50836503	FASTA	325	35,643
	10 20 30 40 50 60 MNLNKHSERK FDLITVGRAC IDLNAVEYNR PMEETMTFSK YVGGSPANIA IGTAKLGLKV 70 80 90 100 110 120 GFIGKISADQ HGRFIEKYMR DLSINTDGMV KDTEGRKVGL AFTEIKSPDE CSILMYRENV 130 140 150 160 170 180 ADLYLTPEEI SEDYIKEARV LLISGTALAQ SPSREAVLKA VSLARKNDVA VAFELDYRPY 190 200 210 220 230 240 TWTNTEETAV YYSLVAEQAD VIIGTRDEFD MMENQVGGKN EATKAHLFQH QAEIVVIKHG 250 260 270 280 290 300 VEGSFAYTKA GETFQAKAYK TKVLKTFGAG DSYASAFLYG LFSGESIETA LKYGSAAASI 310 320 VVSKHSSSDA MPTADEIKAL IAQAE

References

[1]

"Comparative genomics and transcriptomics of lineages I, II, and III strains of Listeria monocytogenes." Hain T., Ghai R., Billion A., Kuenne C.T., Steinweg C., Izar B., Mohamed W., Mraheil M., Domann E., Schaffrath S., Karst U., Goesmann A., Oehm S., Puhler A., Merkl R., Vorwerk S., Glaser P., Garrido P. , Rusniok C., Buchrieser C., Goebel W., Chakraborty T. BMC Genomics 13:144-144(2012) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIP80459.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM242711 Genomic DNA. Translation: CAS04171.1.
RefSeq	YP_002757117.1. NC_012488.1.
3D structure databases
ProteinModelPortal	C1KZA1.
SMR	C1KZA1. Positions 7-325.
ModBase	Search...
Protein-protein interaction databases
STRING	634178.Lm4b_00403.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAS04171; CAS04171; Lm4b_00403.
GeneID	7702104.
KEGG	lmc:Lm4b_00403.
PATRIC	20303921. VBILisMon88360_0396.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000235951.
KO	K03338.
OMA	ANEINRP.
ProtClustDB	CLSK873289.
Enzyme and pathway databases
BioCyc	LMON568819:GJF9-590-MONOMER.
UniPathway	UPA00076; UER00146.
Family and domain databases
HAMAP	MF_01668. IolC.
InterPro	IPR002173. Carboh/pur_kinase_PfkB_CS. IPR022841. DKG_kinase. IPR011611. PfkB_dom. [Graphical view]
Pfam	PF00294. PfkB. 1 hit. [Graphical view]
PROSITE	PS00583. PFKB_KINASES_1. False negative. PS00584. PFKB_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLC_LISMC

Accession

Primary (citable) accession number: C1KZA1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	May 26, 2009
Last modified:	May 1, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program