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Protein

5-deoxy-glucuronate isomerase

Gene

iolB

Organism
Listeria monocytogenes serotype 4b (strain CLIP80459)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the isomerization of 5-deoxy-glucuronate (5DG) to 5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D-gluconate).UniRule annotation

Catalytic activityi

5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate.UniRule annotation

Pathwayi: myo-inositol degradation into acetyl-CoA

This protein is involved in step 4 of the subpathway that synthesizes acetyl-CoA from myo-inositol.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. 5-deoxy-glucuronate isomerase (iolB)
  5. 5-dehydro-2-deoxygluconokinase (iolC)
  6. no protein annotated in this organism
  7. Methylmalonate semialdehyde dehydrogenase [acylating] (iolA)
This subpathway is part of the pathway myo-inositol degradation into acetyl-CoA, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from myo-inositol, the pathway myo-inositol degradation into acetyl-CoA and in Polyol metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

UniPathwayiUPA00076; UER00920.

Names & Taxonomyi

Protein namesi
Recommended name:
5-deoxy-glucuronate isomeraseUniRule annotation (EC:5.3.1.30UniRule annotation)
Short name:
5DG isomeraseUniRule annotation
Gene namesi
Name:iolBUniRule annotation
Ordered Locus Names:Lm4b_00402
OrganismiListeria monocytogenes serotype 4b (strain CLIP80459)
Taxonomic identifieri568819 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002158871 – 2735-deoxy-glucuronate isomeraseAdd BLAST273

Structurei

3D structure databases

ProteinModelPortaliC1KZA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isomerase IolB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000239754.
KOiK03337.
OMAiEGCTSSY.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_01673. IolB. 1 hit.
InterProiIPR024203. Deoxy-glucuronate_isom_IolB.
IPR023770. IolB_Bacilli.
IPR021120. KduI/IolB_isomerase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF04962. KduI. 1 hit.
[Graphical view]
PIRSFiPIRSF036628. IolB. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR04378. myo_inos_iolB. 1 hit.

Sequencei

Sequence statusi: Complete.

C1KZA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKLLRKPLN ERIAPGITFV QDINQANSPL SYVGFRLIEM EKGAIYQEEL
60 70 80 90 100
TDLECCIVAL TGKITVSEGD NIFAEIGTRA NVFEKIPTDS VFISGGRTFQ
110 120 130 140 150
VKADTEKARV ALCYSQANRD LPTTLIKASD NSIEQRGKYQ NKRLVHNILP
160 170 180 190 200
DVSEVASSLL VVEVYTDGGN FSSYPPHKHD RDNLPAESLL EESYYHEINP
210 220 230 240 250
EQGFIFQRVY TDDRTLDETM AVEHQNAVIV PEGYHPVGVP DGYDSYYLNV
260 270
MAGPKRVWKF HNDPDHEWIL ERD
Length:273
Mass (Da):30,884
Last modified:May 26, 2009 - v1
Checksum:i5EACF8A941D30171
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM242711 Genomic DNA. Translation: CAS04170.1.
RefSeqiWP_003724309.1. NC_012488.1.

Genome annotation databases

EnsemblBacteriaiCAS04170; CAS04170; Lm4b_00402.
KEGGilmc:Lm4b_00402.
PATRICi20303919. VBILisMon88360_0395.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM242711 Genomic DNA. Translation: CAS04170.1.
RefSeqiWP_003724309.1. NC_012488.1.

3D structure databases

ProteinModelPortaliC1KZA0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAS04170; CAS04170; Lm4b_00402.
KEGGilmc:Lm4b_00402.
PATRICi20303919. VBILisMon88360_0395.

Phylogenomic databases

HOGENOMiHOG000239754.
KOiK03337.
OMAiEGCTSSY.

Enzyme and pathway databases

UniPathwayiUPA00076; UER00920.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_01673. IolB. 1 hit.
InterProiIPR024203. Deoxy-glucuronate_isom_IolB.
IPR023770. IolB_Bacilli.
IPR021120. KduI/IolB_isomerase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF04962. KduI. 1 hit.
[Graphical view]
PIRSFiPIRSF036628. IolB. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR04378. myo_inos_iolB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIOLB_LISMC
AccessioniPrimary (citable) accession number: C1KZA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 26, 2009
Last modified: November 2, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.